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Cellosaurus MDA-MB-231br (CVCL_A0YY)

[Text version]
Cell line name MDA-MB-231br
Synonyms MDA-231BR
Accession CVCL_A0YY
Resource Identification Initiative To cite this cell line use: MDA-MB-231br (RRID:CVCL_A0YY)
Comments Group: Triple negative breast cancer (TNBC) cell line.
Population: Caucasian.
Characteristics: Metastatic to brain. Established after injection of the parent cell line in the left ventricle of the heart of female nude mice and retrieving the brain metastatic cells and repeating this procedure 6 times.
Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations
  • Gene deletion; HGNC; 1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
  • Gene deletion; HGNC; 1788; CDKN2B; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 1097; BRAF; Simple; p.Gly464Val (c.1391G>T); ClinVar=VCV000040364; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 6407; KRAS; Simple; p.Gly13Asp (c.38G>A); ClinVar=VCV000012580; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Arg280Lys (c.839G>A); ClinVar=VCV000376657; Zygosity=Homozygous (from parent cell line).
Disease Breast adenocarcinoma (NCIt: C5214)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0062 (MDA-MB-231)
CVCL_B0A0 (MDA-MB-231br/eGFP)
Sex of cell Female
Age at sampling 51Y
Category Cancer cell line

PubMed=11499871; DOI=10.1359/jbmr.2001.16.8.1486
Yoneda T., Williams P.J., Hiraga T., Niewolna M., Nishimura R.
A bone-seeking clone exhibits different biological properties from the MDA-MB-231 parental human breast cancer cells and a brain-seeking clone in vivo and in vitro.
J. Bone Miner. Res. 16:1486-1495(2001)

PubMed=33264355; DOI=10.1371/journal.pone.0243156
De Meulenaere V., Descamps B., De Wever O., Vanhove C., Deblaere K.
In vivo selection of the MDA-MB-231br/eGFP cancer cell line to obtain a clinically relevant rat model for triple negative breast cancer brain metastasis.
PLoS ONE 15:E0243156-E0243156(2020)

Cell line databases/resources cancercelllines; CVCL_A0YY
Encyclopedic resources Wikidata; Q108820878
Entry history
Entry creation23-Sep-2021
Last entry update05-Oct-2023
Version number6