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Cellosaurus A549-A2-ESO (CVCL_A0WA)

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Cell line name A549-A2-ESO
Synonyms A549-NY-ESO-1-A2-CBG
Accession CVCL_A0WA
Resource Identification Initiative To cite this cell line use: A549-A2-ESO (RRID:CVCL_A0WA)
Comments Population: Caucasian.
Characteristics: Transduced with both a CBG-T2A-GFP construct and a NY-ESO-1-T2A-HLA-A2 construct.
Genetic integration: Method=Transduction; Gene=FPbase; R9NL8; eGFP (Note=Enhanced GFP).
Genetic integration: Method=Transduction; Gene=HGNC; HGNC:24198; CTAG1A.
Genetic integration: Method=Transduction; Gene=HGNC; HGNC:4931; HLA-A (Note=Allele A*02).
Genetic integration: Method=Transduction; Gene=Click beetle green luciferase (CBG).
Derived from site: In situ; Lung; UBERON=UBERON_0002048.
Sequence variations
  • Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Gly12Ser (c.34G>A); ClinVar=VCV000012584; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11389; STK11; Simple; p.Gln37Ter (c.109C>T); ClinVar=VCV000376334; Zygosity=Homozygous (from parent cell line).
Disease Lung adenocarcinoma (NCIt: C3512)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_A0VZ (A549-CBG)
Sex of cell Male
Age at sampling 58Y
Category Cancer cell line
Publications

PubMed=33537176; DOI=10.1080/2162402X.2021.1873607; PMCID=PMC7833767
Marina Martinez, Soyeon Kim, Naomi St Jean, Shaun O'Brien, Lu-Rong Lian, Jing Sun, Raluca I. Verona, Edmund Moon;
Addition of anti-TIM3 or anti-TIGIT antibodies to anti-PD1 blockade augments human T cell adoptive cell transfer.
OncoImmunology 10:e1873607.1-e1873607.16(2021)

Cross-references
Cell line databases/resources cancercelllines; CVCL_A0WA
Encyclopedic resources Wikidata; Q108819812
Entry history
Entry creation23-Sep-2021
Last entry update10-Apr-2025
Version number9