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Cellosaurus MS-EwS-6 (CVCL_A0VN)

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Cell line name MS-EwS-6
Synonyms MS-PES-6
Accession CVCL_A0VN
Resource Identification Initiative To cite this cell line use: MS-EwS-6 (RRID:CVCL_A0VN)
Comments Miscellaneous: Gene fusion, site of sampling and age of donor from personal communication of Rossig, Claudia.
Derived from site: Metastatic; Thoracic cavity; UBERON=UBERON_0002224.
Sequence variations
  • Gene fusion; HGNC; HGNC:3508; EWSR1 + HGNC; HGNC:3749; FLI1; Name(s)=EWSR1-FLI1, EWS-FLI1 (Direct_author_submission).
Disease Ewing sarcoma (NCIt: C4817)
Ewing sarcoma (ORDO: Orphanet_319)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 19Y
Category Cancer cell line
STR profile Source(s): PubMed=30879952

Markers:
AmelogeninX,Y
CSF1PO10,12
D3S135814
D5S81813
D7S82012,13
D13S3178,13
D16S5398,11
FGA20,24
TH016
TPOX8
vWA16,17

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Publications

PubMed=29464090; DOI=10.18632/oncotarget.23815; PMCID=PMC5814230
Christian Spurny, Sareetha Kailayangiri, Bianca Altvater, Silke Jamitzky, Wolfgang Hartmann, Eva Wardelmann, Andreas Ranft, Uta Dirksen, Susanne Amler, Jendrik Hardes, Maike Fluegge ...Show all 15 authors... , Jutta Meltzer, Nicole Farwick, Lea Greune, Claudia Rossig; Show fewer authors
T cell infiltration into Ewing sarcomas is associated with local expression of immune-inhibitory HLA-G.
Oncotarget 9:6536-6549(2018)

PubMed=30879952; DOI=10.1016/j.ymthe.2019.02.014; PMCID=PMC6520468
Sareetha Kailayangiri, Bianca Altvater, Stefanie Lesch, Sebastian T. Balbach, Claudia Gottlich, Johanna Kuhnemundt, Jan-Henrik Mikesch, Sonja Schelhaas, Silke Jamitzky, Jutta Meltzer, Nicole Farwick ...Show all 20 authors... , Lea Greune, Maike Fluegge, Kornelius Kerl, Holger N. Lode, Nikolai Siebert, Ingo Muller, Heike Walles, Wolfgang Hartmann, Claudia Rossig; Show fewer authors
EZH2 inhibition in Ewing sarcoma upregulates GD2 expression for targeting with gene-modified T cells.
Mol. Ther. 27:933-946(2019)

Cross-references
Encyclopedic resources Wikidata; Q108820994
Entry history
Entry creation23-Sep-2021
Last entry update19-Dec-2024
Version number6