Cellosaurus cell line MCIR1 (CVCL

Cross-references
Cell line name	MCIR1
Synonyms	Mayo Clinic Ibrutinib-Resistant Line 1
Accession	CVCL_A0DE
Resource Identification Initiative	To cite this cell line use: MCIR1 (RRID:CVCL_A0DE)
Comments	Characteristics: Obtained from a ibrutinib-resistant tumor clone (PubMed=34214199). Doubling time: 32 hours (PubMed=34214199). Omics: Transcriptomics; RNAseq. Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Sequence variations	Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Homozygous (PubMed=34214199). Gene deletion; HGNC; HGNC:1788; CDKN2B; Zygosity=Homozygous (PubMed=34214199).
Disease	Mantle cell lymphoma (NCIt: C4337) Mantle cell lymphoma (ORDO: Orphanet_52416)
Species of origin	Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell	Male
Age at sampling	57Y
Category	Cancer cell line
Publications	PubMed=34214199; DOI=10.1111/ejh.13682; PMCID=PMC8654320 Xiao-Sheng Wu, Kevin E. Nowakowski, Jithma P. Abeykoon, Michelle K. Manske, Mary Joan Stenson, Michael M. Timm, Curtis A. Hanson, Daniel L. Van Dyke, Surendra Dasari, Thomas E. Witzig; MCIR1: a patient-derived mantle cell lymphoma line for discovering new treatments for ibrutinib resistance. Eur. J. Haematol. 107:458-465(2021)
Encyclopedic resources	Wikidata; Q108820864
Entry history
Entry creation	23-Sep-2021
Last entry update	10-Apr-2025
Version number	6