Cellosaurus cell line UMB-SCC-745 (CVCL

Cellosaurus UMB-SCC-745 (CVCL_A093)

Cross-references
Cell line name	UMB-SCC-745
Synonyms	University of Marburg-Squamous Cell Carcinoma-745
Accession	CVCL_A093
Resource Identification Initiative	To cite this cell line use: UMB-SCC-745 (RRID:CVCL_A093)
Comments	Caution: Indicated as originating from tonsil in PubMed=16035614 and from orapharynx in PubMed=16203773 and PubMed=19414362.
Sequence variations	Mutation; HGNC; HGNC:11998; TP53; Simple; p.Glu349Ter (c.1045G>T); ClinVar=VCV000634695; Zygosity=Unspecified (PubMed=16203773).
Disease	Oropharyngeal squamous cell carcinoma (NCIt: C8181) Squamous cell carcinoma of the oropharynx (ORDO: Orphanet_500478)
Species of origin	Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell	Male
Age at sampling	48Y
Category	Cancer cell line
Publications	PubMed=16035614; DOI=10.1007/s10585-004-6918-5 Robert Mandic, Thomas Ludwig, Hans Oberleithner, Jochen Alfred Werner; Evaluation of head and neck squamous cell carcinoma invasiveness by the electrical resistance breakdown assay. Clin. Exp. Metastasis 21:699-704(2004) PubMed=16203773; DOI=10.1158/1078-0432.CCR-05-0378 Robert Mandic, Chantal J. Schamberger, Julia F. Muller, Matthias Geyer, Li Zhu, Thomas E. Carey, Reidar Grenman, Anja A. Dunne, Jochen Alfred Werner; Reduced cisplatin sensitivity of head and neck squamous cell carcinoma cell lines correlates with mutations affecting the COOH-terminal nuclear localization signal of p53. Clin. Cancer Res. 11:6845-6852(2005) PubMed=19414362 Robert Mandic, Chantal J. Rodgarkia-Dara, Vanessa Krohn, Susanne Wiegand, Reidar Grenman, Jochen Alfred Werner; Cisplatin resistance of the HNSCC cell line UT-SCC-26A can be overcome by stimulation of the EGF-receptor. Anticancer Res. 29:1181-1187(2009)
Cell line databases/resources	cancercelllines; CVCL_A093
Encyclopedic resources	Wikidata; Q54991067
Polymorphism and mutation databases	Cosmic; 1483461 IARC_TP53; 23609
Entry history
Entry creation	06-Jun-2012
Last entry update	19-Dec-2024
Version number	13