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Cellosaurus YCUB-5 (CVCL_A085)

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Cell line name YCUB-5
Synonyms YCUB5; YcuB5; Yokohama City University BCP-ALL-5
Accession CVCL_A085
Resource Identification Initiative To cite this cell line use: YCUB-5 (RRID:CVCL_A085)
Comments Population: Japanese.
Doubling time: ~72 hours (DSMZ=ACC-964).
Derived from site: In situ; Bone marrow; UBERON=UBERON_0002371.
Sequence variations
  • Gene fusion; HGNC; HGNC:14281; CRLF2 + HGNC; HGNC:15524; P2RY8; Name(s)=P2RY8-CRLF2; Note=P2RY8 exon 1 fused to CRLF2 exon 1 (PubMed=29786757).
  • Mutation; HGNC; HGNC:6192; JAK2; Simple; p.Arg683Ile (c.2048G>T); Zygosity=Unspecified (PubMed=29786757).
  • Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Gly12Asp (c.35G>A); ClinVar=VCV000012582; Zygosity=Unspecified (PubMed=29786757).
Disease Childhood B acute lymphoblastic leukemia (NCIt: C9140)
Precursor B-cell acute lymphoblastic leukemia (ORDO: Orphanet_99860)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Originate from same individual CVCL_A086 ! YCUB-5R
Sex of cell Male
Age at sampling 12Y
Category Cancer cell line
STR profile Source(s): DSMZ=ACC-964

Markers:
AmelogeninX,Y
CSF1PO10,11
D2S133818,23
D3S135815
D5S8189,10
D7S8209,11
D8S117914,16
D13S3178
D16S5399,11
D18S5113,15
D19S43312
D21S1130,30.2
FGA20,21
Penta D9,14
Penta E11,17
TH016,9
TPOX8,12
vWA16

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Publications

PubMed=19157546; DOI=10.1016/j.leukres.2008.12.003
Hiroaki Goto, Takuya Naruto, Reo Tanoshima, Hiromi Kato, Tomoko Yokosuka, Masakatsu Yanagimachi, Hisaki Fujii, Shumpei Yokota, Hiromi Komine;
Chemo-sensitivity in a panel of B-cell precursor acute lymphoblastic leukemia cell lines, YCUB series, derived from children.
Leuk. Res. 33:1386-1391(2009)

PubMed=29786757; DOI=10.1007/s12185-018-2474-7
Chihiro Tomoyasu, Toshihiko Imamura, Toshihiro Tomii, Mio Yano, Daisuke Asai, Hiroaki Goto, Akira Shimada, Masashi Sanada, Shotaro Iwamoto, Junko Takita, Masayoshi Minegishi ...Show all 14 authors... , Takeshi Inukai, Kanji Sugita, Hajime Hosoi; Show fewer authors
Copy number abnormality of acute lymphoblastic leukemia cell lines based on their genetic subtypes.
Int. J. Hematol. 108:312-318(2018)

PubMed=35124168; DOI=10.1016/j.jsbmb.2022.106068
Minori Tamai, Shin Kasai, Koshi Akahane, Thao Nguyen Thu, Keiko Kagami, Chiaki Komatsu, Masako Abe, Atsushi Watanabe, Kumiko Goi, Kunio Miyake, Toshiya Inaba ...Show all 17 authors... , Junko Takita, Hiroaki Goto, Masayoshi Minegishi, Shotaro Iwamoto, Kanji Sugita, Takeshi Inukai; Show fewer authors
Glucocorticoid receptor gene mutations confer glucocorticoid resistance in B-cell precursor acute lymphoblastic leukemia.
J. Steroid Biochem. Mol. Biol. 218:106068.1-106068.12(2022)

Cross-references
Cell line collections (Providers) DSMZ; ACC-964
Encyclopedic resources Wikidata; Q54995375
Entry history
Entry creation06-Jun-2012
Last entry update19-Dec-2024
Version number13