Cellosaurus logo
expasy logo

Cellosaurus YCUB-2 (CVCL_A082)

[Text version]
Cell line name YCUB-2
Synonyms YCUB2; YcuB2; Yokohama City University BCP-ALL-2
Accession CVCL_A082
Resource Identification Initiative To cite this cell line use: YCUB-2 (RRID:CVCL_A082)
Comments Population: Japanese.
Doubling time: ~24 hours (DSMZ=ACC-961).
Omics: Phenotyping; Drug screening.
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Sequence variations
Disease B acute lymphoblastic leukemia with TCF3-HLF rearrangement (NCIt: C199241)
B-lymphoblastic leukemia/lymphoma with t(17;19) (ORDO: Orphanet_641375)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 4Y
Category Cancer cell line
STR profile Source(s): DSMZ=ACC-961

Markers:
AmelogeninX,Y
CSF1PO12
D2S133820,23
D3S135817,18
D5S81811,12
D7S82010,11
D8S117914,15
D13S3178,11
D16S5399
D18S5113
D19S43313
D21S1129,33.2
FGA21,22
Penta D11
Penta E11,16
TH017,8
TPOX8,9
vWA18

Run an STR similarity search on this cell line
Publications

PubMed=11417493; DOI=10.1038/sj.leu.2402120
Hiroyuki Takahashi, Hiroaki Goto, Tetsunori Funabiki, Hisaki Fujii, Sakurado Yamazaki, Kouki Fujioka, Koichiro Ikuta, Shunro Kai;
Expression of two types of E2A-HLF fusion proteins in YCUB-2, a novel cell line established from B-lineage leukemia with t(17;19).
Leukemia 15:995-997(2001)

PubMed=19157546; DOI=10.1016/j.leukres.2008.12.003
Hiroaki Goto, Takuya Naruto, Reo Tanoshima, Hiromi Kato, Tomoko Yokosuka, Masakatsu Yanagimachi, Hisaki Fujii, Shumpei Yokota, Hiromi Komine;
Chemo-sensitivity in a panel of B-cell precursor acute lymphoblastic leukemia cell lines, YCUB series, derived from children.
Leuk. Res. 33:1386-1391(2009)

PubMed=20147975; DOI=10.1038/leu.2010.8
Koshi Akahane, T. Inukai, T. Inaba, H. Kurosawa, Alfred Thomas Look, Nobutaka Kiyokawa, J. Fujimoto, H. Goto, M. Endo, X. Zhang, K. Hirose ...Show all 17 authors... , Itaru Kuroda, Hiroko Honna, Keiko Kagami, Kumiko Goi, Shinpei Nakazawa, K. Sugita; Show fewer authors
Specific induction of CD33 expression by E2A-HLF: the first evidence for aberrant myeloid antigen expression in ALL by a fusion transcription factor.
Leukemia 24:865-869(2010)

PubMed=20519628; DOI=10.1182/blood-2009-09-244673
Kinuko Hirose, Takeshi Inukai, Jiro Kikuchi, Yusuke Furukawa, Tomokatsu Ikawa, Hiroshi Kawamoto, S. Helen Oram, Berthold Gottgens, Nobutaka Kiyokawa, Yoshitaka Miyagawa, Hajime Okita ...Show all 22 authors... , Koshi Akahane, Xiao-Chun Zhang, Itaru Kuroda, Hiroko Honna, Keiko Kagami, Kumiko Goi, Hidemitsu Kurosawa, Alfred Thomas Look, Hirotaka Matsui, Toshiya Inaba, Kanji Sugita; Show fewer authors
Aberrant induction of LMO2 by the E2A-HLF chimeric transcription factor and its implication in leukemogenesis of B-precursor ALL with t(17;19).
Blood 116:962-970(2010)

PubMed=20575032; DOI=10.1002/ajh.21738; PMCID=PMC7159455
Takeshi Inukai, Xiu-Ru Zhang, Takeshi Kameyama, Yukiko Suzuki, Kazuhito Yoshikawa, Itaru Kuroda, Atsushi Nemoto, Koshi Akahane, Hiroki Sato, Kumiko Goi, Kazunori Nakamoto ...Show all 15 authors... , Jun-ichi Hamada, Mitsuhiro Tada, Tetsuya Moriuchi, Kanji Sugita; Show fewer authors
A specific linkage between the incidence of TP53 mutations and type of chromosomal translocations in B-precursor acute lymphoblastic leukemia cell lines.
Am. J. Hematol. 85:535-537(2010)

PubMed=29786757; DOI=10.1007/s12185-018-2474-7
Chihiro Tomoyasu, Toshihiko Imamura, Toshihiro Tomii, Mio Yano, Daisuke Asai, Hiroaki Goto, Akira Shimada, Masashi Sanada, Shotaro Iwamoto, Junko Takita, Masayoshi Minegishi ...Show all 14 authors... , Takeshi Inukai, Kanji Sugita, Hajime Hosoi; Show fewer authors
Copy number abnormality of acute lymphoblastic leukemia cell lines based on their genetic subtypes.
Int. J. Hematol. 108:312-318(2018)

PubMed=31305009; DOI=10.1002/cam4.2356; PMCID=PMC6718581
Atsushi Watanabe, Takeshi Inukai, Keiko Kagami, Masako Abe, Masatoshi Takagi, Takashi Fukushima, Hiroko Fukushima, Toru Nanmoku, Kiminori Terui, Tatsuya Ito, Tsutomu Toki ...Show all 29 authors... , Etsuro Ito, Junya Fujimura, Hiroaki Goto, Mikiya Endo, Thomas Look, Mark P. Kamps, Masayoshi Minegishi, Junko Takita, Toshiya Inaba, Hiroyuki Takahashi, Akira Ohara, Daisuke Harama, Tamao Shinohara, Shinpei Somazu, Hiroko Oshiro, Koshi Akahane, Kumiko Goi, Kanji Sugita; Show fewer authors
Resistance of t(17;19)-acute lymphoblastic leukemia cell lines to multiagents in induction therapy.
Cancer Med. 8:5274-5288(2019)

PubMed=32144432; DOI=10.1007/s00280-020-04045-9
Hiroaki Goto, Yuki Yoshino, Mieko Ito, Jun-ichi Nagai, Tadashi Kumamoto, Takesi Inukai, Yukari Sakurai, Naoyuki Miyagawa, Dai Keino, Tomoko Yokosuka, Fuminori Iwasaki ...Show all 14 authors... , Satoshi Hamanoue, Masae Shiomi, Shoko Goto; Show fewer authors
Aurora B kinase as a therapeutic target in acute lymphoblastic leukemia.
Cancer Chemother. Pharmacol. 85:773-783(2020)

PubMed=35124168; DOI=10.1016/j.jsbmb.2022.106068
Minori Tamai, Shin Kasai, Koshi Akahane, Thao Nguyen Thu, Keiko Kagami, Chiaki Komatsu, Masako Abe, Atsushi Watanabe, Kumiko Goi, Kunio Miyake, Toshiya Inaba ...Show all 17 authors... , Junko Takita, Hiroaki Goto, Masayoshi Minegishi, Shotaro Iwamoto, Kanji Sugita, Takeshi Inukai; Show fewer authors
Glucocorticoid receptor gene mutations confer glucocorticoid resistance in B-cell precursor acute lymphoblastic leukemia.
J. Steroid Biochem. Mol. Biol. 218:106068.1-106068.12(2022)

Cross-references
Cell line collections (Providers) DSMZ; ACC-961
Encyclopedic resources Wikidata; Q54995372
Polymorphism and mutation databases IARC_TP53; 28430
Entry history
Entry creation06-Jun-2012
Last entry update14-Aug-2025
Version number15