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Cellosaurus PC14PE6 (CVCL_9W70)

[Text version]
Cell line name PC14PE6
Synonyms PC14-PE6; PC14/PE6
Accession CVCL_9W70
Resource Identification Initiative To cite this cell line use: PC14PE6 (RRID:CVCL_9W70)
Comments Problematic cell line: Contaminated. Parent cell line (PC-14) has been shown to be a PC-9 derivative.
Population: Japanese.
Caution: PC-14-PM4 (Cellosaurus=CVCL_9W69) and PC14PE6 could be identical.
Derived from site: Metastatic; Lymph node; UBERON=UBERON_0000027.
Sequence variations
  • Mutation; HGNC; 3236; EGFR; Simple; p.Glu746_Ala750del (c.2235_2249del15); ClinVar=VCV000163343; Zygosity=Unspecified (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Arg248Gln (c.743G>A); ClinVar=VCV000012356; Zygosity=Homozygous (from parent cell line).
Disease Lung adenocarcinoma (NCIt: C3512)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_1640 (PC-14)
CVCL_9W72 (PC14PE6/AS2)
Sex of cell Male
Age at sampling 45Y
Category Cancer cell line

Yano S., Herbst R.S., Shinohara H., Knighton B., Bucana C.D., Killion J.J., Wood J., Fidler I.J.
Treatment for malignant pleural effusion of human lung adenocarcinoma by inhibition of vascular endothelial growth factor receptor tyrosine kinase phosphorylation.
Clin. Cancer Res. 6:957-965(2000)

Yano S., Shinohara H., Herbst R.S., Kuniyasu H., Bucana C.D., Ellis L.M., Davis D.W., McConkey D.J., Fidler I.J.
Expression of vascular endothelial growth factor is necessary but not sufficient for production and growth of brain metastasis.
Cancer Res. 60:4959-4967(2000)

PubMed=19771249; DOI=10.4143/crt.2006.38.4.234
Cui Z.-Y., Ahn J.-S., Lee J.-Y., Kim W.-S., Lim H.-Y., Jeon H.-J., Suh S.-W., Kim J.-H., Kong W.-H., Kang J.-M., Nam D.-H., Park K.
Mouse orthotopic lung cancer model induced by PC14PE6.
Cancer Res. Treat. 38:234-239(2006)

Cell line databases/resources cancercelllines; CVCL_9W70
Encyclopedic resources Wikidata; Q54938560
Entry history
Entry creation23-Feb-2016
Last entry update05-Oct-2023
Version number14