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Cellosaurus PC14PE6 (CVCL_9W70)

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Cell line name PC14PE6
Synonyms PC14-PE6; PC14/PE6
Accession CVCL_9W70
Resource Identification Initiative To cite this cell line use: PC14PE6 (RRID:CVCL_9W70)
Comments Problematic cell line: Contaminated. Parent cell line (PC-14) has been shown to be a PC-9 derivative.
Population: Chinese; Han and Japanese.
Caution: PC-14-PM4 (Cellosaurus=CVCL_9W69) and PC14PE6 could be identical.
Derived from site: Metastatic; Lymph node; UBERON=UBERON_0000029.
Sequence variations
  • Mutation; HGNC; HGNC:3236; EGFR; Simple; p.Glu746_Ala750del (c.2235_2249del15); ClinVar=VCV000163343; Zygosity=Unspecified (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg248Gln (c.743G>A); ClinVar=VCV000012356; Zygosity=Homozygous (from parent cell line).
Disease Lung adenocarcinoma (NCIt: C3512)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_1640 (PC-14)
Children:
CVCL_9W72 (PC14PE6/AS2)
Sex of cell Male
Age at sampling 45Y
Category Cancer cell line
Publications

PubMed=10741721
Seiji Yano, Roy S. Herbst, Hisashi Shinohara, Barbara Knighton, Corazon D. Bucana, Jerald J. Killion, Jeanette Wood, Isaiah Joshua Fidler;
Treatment for malignant pleural effusion of human lung adenocarcinoma by inhibition of vascular endothelial growth factor receptor tyrosine kinase phosphorylation.
Clin. Cancer Res. 6:957-965(2000)

PubMed=10987313
Seiji Yano, Hisashi Shinohara, Roy S. Herbst, Hiroki Kuniyasu, Corazon D. Bucana, Lee M. Ellis, Darren W. Davis, David J. McConkey, Isaiah Joshua Fidler;
Expression of vascular endothelial growth factor is necessary but not sufficient for production and growth of brain metastasis.
Cancer Res. 60:4959-4967(2000)

PubMed=19771249; DOI=10.4143/crt.2006.38.4.234; PMCID=PMC2741646
Zheng Yun Cui, Jin Seok Ahn, Jee Yun Lee, Won Seog Kim, Ho Yeong Lim, Hyun Jung Jeon, Soo Won Suh, Jin Hoon Kim, Won Ho Kong, Ji Min Kang, Do Hyun Nam, Keunchil Park;
Mouse orthotopic lung cancer model induced by PC14PE6.
Cancer Res. Treat. 38:234-239(2006)

Cross-references
Cell line databases/resources cancercelllines; CVCL_9W70
Encyclopedic resources Wikidata; Q54938560
Entry history
Entry creation23-Feb-2016
Last entry update19-Dec-2024
Version number16