Cellosaurus cell line RC (CVCL

Cellosaurus RC (CVCL_9U45)

Cell line name

Accession

CVCL_9U45

To cite this cell line use: RC (RRID:CVCL_9U45)

Comments

Doubling time: ~4-5 days (PubMed=26515759).
Miscellaneous: STR profile in PubMed=26515759 table 3 is erroneous; correct STR profile obtained from personal communication of Pham, Lan V.
Derived from site: In situ; Pleural effusion; UBERON=UBERON_0000175.

Sequence variations

Gene fusion; HGNC; HGNC:990; BCL2 + HGNC; HGNC:5477; IGH; Name(s)=IGH-BCL2 (PubMed=26515759).
Gene fusion; HGNC; HGNC:5477; IGH + HGNC; HGNC:7553; MYC; Name(s)=MYC-IGH (PubMed=26515759).

Disease

High grade B-cell lymphoma with MYC and BCL2 or BCL6 rearrangements (NCIt: C125904)
High grade B-cell lymphoma with MYC and/or BCL2 and/or BCL6 rearrangement (ORDO: Orphanet_480541)

Species of origin

Homo sapiens (Human) (NCBI Taxonomy: 9606)

Sex of cell

Female

Age at sampling

71Y

Category

Cancer cell line

STR profile

Source(s): ATCC=CRL-3382; PubMed=26515759

Markers:

Amelogenin	X
CSF1PO	10,12
D3S1358	17,19
D5S818	12,13
D7S820	10,13
D8S1179	13,15
D13S317	9,11
D16S539	8,12
D18S51	17
D21S11	28,30
FGA	19,21
TH01	6
TPOX	8
vWA	15,18

Publications

PubMed=20664054; DOI=10.1182/blood-2009-12-257378; PMCID=PMC2981542
Lan V. Pham, Archito T. Tamayo, Chang-Ping Li, Carlos E. Bueso-Ramos, Richard Joseph Ford Jr.;
An epigenetic chromatin remodeling role for NFATc1 in transcriptional regulation of growth and survival genes in diffuse large B-cell lymphomas.
Blood 116:3899-3906(2010)

PubMed=26515759; DOI=10.1186/s13045-015-0218-1; PMCID=PMC4627381
Lan V. Pham, Gary Lu, Archito T. Tamayo, Juan Chen, Pramoda Challagundla, Jeffrey L. Jorgensen, L. Jeffrey Medeiros, Richard Joseph Ford Jr.;
Establishment and characterization of a novel MYC/BCL2 'double-hit' diffuse large B cell lymphoma cell line, RC.
J. Hematol. Oncol. 8:121.1-121.11(2015)

PubMed=29416618; DOI=10.18632/oncotarget.20378; PMCID=PMC5787470
Wei Liu, Juan Chen, Archito T. Tamayo, Chang-Geng Ruan, Li Li, Shou-Hao Zhou, Chan Shen, Ken H. Young, Jason Westin, Richard E. Davis, Shi-Min Hu ...Show all 14 authors... , L. Jeffrey Medeiros, Richard Joseph Ford Jr., Lan V. Pham; Show fewer authors
Preclinical efficacy and biological effects of the oral proteasome inhibitor ixazomib in diffuse large B-cell lymphoma.
Oncotarget 9:346-360(2018)

PubMed=29666304; DOI=10.1158/1078-0432.CCR-17-3004
Lan V. Pham, Sheng-Jian Huang, Hui Zhang, Jun Zhang, Taylor Bell, Shou-Hao Zhou, Elizabeth Pogue, Zhi-Yong Ding, Laura Lam, Jason Westin, R. Eric Davis ...Show all 17 authors... , Ken H. Young, L. Jeffrey Medeiros, Richard Joseph Ford Jr., Krystle Nomie, Leo Zhang, Michael Wang; Show fewer authors
Strategic therapeutic targeting to overcome venetoclax resistance in aggressive B-cell lymphomas.
Clin. Cancer Res. 24:3967-3980(2018)

Cross-references

Cell line collections (Providers)

ATCC; CRL-3382

Encyclopedic resources

Wikidata; Q54949366

Entry history

Entry creation

23-Feb-2016

Last entry update

14-Aug-2025

Version number