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Cellosaurus VACO 457 (CVCL_9T31)

[Text version]
Cell line name VACO 457
Synonyms Vaco 457; Vaco-457; VACO457; Vaco457; V457
Accession CVCL_9T31
Resource Identification Initiative To cite this cell line use: VACO 457 (RRID:CVCL_9T31)
Comments Microsatellite instability: Instable (MSI) (PubMed=25926053).
Omics: Transcriptomics; Microarray.
Derived from site: Metastatic; Liver; UBERON=UBERON_0002107.
Sequence variations
Disease Colon carcinoma (NCIt: C4910)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Age at sampling 32Y
Category Cancer cell line
STR profile Source(s): PubMed=25926053

Markers:
AmelogeninX
CSF1PO11,14
D5S81811,16
D7S82012,13
D13S31711,12
D16S53911,12
D21S1129,32
TH017,9
TPOX8,9
vWA18

Run an STR similarity search on this cell line
Publications

PubMed=7704014; DOI=10.1038/ng0195-10
Luis Teixeira da Costa, Bo Liu, Wafik S. El-Deiry, Stanley R. Hamilton, Kenneth Wayne Kinzler, Bert Vogelstein, Sanford David Markowitz, James K.V. Willson, Albert de la Chapelle, Kathleen M. Downey, Antero G. So;
Polymerase delta variants in RER colorectal tumours.
Nat. Genet. 9:10-11(1995)

PubMed=7761852; DOI=10.1126/science.7761852
Sanford David Markowitz, Jing Wang, Lois Lemmermann Myeroff, Ramon Parsons, Lu-Zhe Sun, James D. Lutterbaugh, Robert S. Fan, Elizabeth Zborowska, Kenneth Wayne Kinzler, Bert Vogelstein, Michael G. Brattain, James K.V. Willson;
Inactivation of the type II TGF-beta receptor in colon cancer cells with microsatellite instability.
Science 268:1336-1338(1995)

PubMed=7824277
James Richard Eshleman, Evan Z. Lang, Gordana K. Bowerfind, Ramon Parsons, Bert Vogelstein, James K.V. Willson, Martina L. Veigl, Wallace David Sedwick, Sanford David Markowitz;
Increased mutation rate at the hprt locus accompanies microsatellite instability in colon cancer.
Oncogene 10:33-37(1995)

PubMed=8755562; DOI=10.1073/pnas.93.15.7832; PMCID=PMC38834
Da-Cai Liu, Eric Pearlman, Eugenia Diaconu, Kun Guo, Hiroshi Mori, Tariq Haqqi, Sanford David Markowitz, James K.V. Willson, Man-Sun Sy;
Expression of hyaluronidase by tumor cells induces angiogenesis in vivo.
Proc. Natl. Acad. Sci. U.S.A. 93:7832-7837(1996)

PubMed=9515795
Andrew B. Sparks, Patrice J. Morin, Bert Vogelstein, Kenneth Wayne Kinzler;
Mutational analysis of the APC/beta-catenin/Tcf pathway in colorectal cancer.
Cancer Res. 58:1130-1134(1998)

PubMed=9715273; DOI=10.1038/sj.onc.1201986
James Richard Eshleman, Graham Casey, Mary E. Kochera, Wallace David Sedwick, Sandra E. Swinler, Martina L. Veigl, James K.V. Willson, Stuart Schwartz, Sanford David Markowitz;
Chromosome number and structure both are markedly stable in RER colorectal cancers and are not destabilized by mutation of p53.
Oncogene 17:719-725(1998)

PubMed=11314036; DOI=10.1038/sj.onc.1204211
Eva Forgacs, Jonathan D. Wren, Craig Kamibayashi, Masashi Kondo, Xie L. Xu, Sanford David Markowitz, Gail E. Tomlinson, Carolyn Y. Muller, Adi F. Gazdar, Harold Ray Garner, John D. Minna;
Searching for microsatellite mutations in coding regions in lung, breast, ovarian and colorectal cancers.
Oncogene 20:1005-1009(2001)

PubMed=12615714
Paula M. Hempen, Lin Zhang, Ravi K. Bansal, Christine A. Iacobuzio-Donahue, Kathleen M. Murphy, Anirban Maitra, Bert Vogelstein, Robert H. Whitehead, Sanford David Markowitz, James K.V. Willson, Charles J. Yeo ...Show all 13 authors... , Ralph H. Hruban, Scott E. Kern; Show fewer authors
Evidence of selection for clones having genetic inactivation of the activin A type II receptor (ACVR2) gene in gastrointestinal cancers.
Cancer Res. 63:994-999(2003)

PubMed=25926053; DOI=10.1038/ncomms8002
Enzo Medico, Mariangela Russo, Gabriele Picco, Carlotta Cancelliere, Emanuele Valtorta, Giorgio Corti, Michela Buscarino, Claudio Isella, Simona Lamba, Barbara Martinoglio, Silvio Veronese ...Show all 19 authors... , Salvatore Siena, Andrea Sartore-Bianchi, Marco Beccuti, Marcella Mottolese, Michael Linnebacher, Francesca Cordero, Federica Di Nicolantonio, Alberto Bardelli; Show fewer authors
The molecular landscape of colorectal cancer cell lines unveils clinically actionable kinase targets.
Nat. Commun. 6:7002.1-7002.10(2015)

Cross-references
Cell line databases/resources cancercelllines; CVCL_9T31
Encyclopedic resources Wikidata; Q54992751
Gene expression databases GEO; GSM1448081
Polymorphism and mutation databases Cosmic; 2646667
Cosmic; 2667982
Cosmic; 2727476
IARC_TP53; 9389
Entry history
Entry creation23-Feb-2016
Last entry update10-Apr-2025
Version number18