Cellosaurus cell line OV-4485 (CVCL

Cellosaurus OV-4485 (CVCL_9T21)

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Cell line name

OV-4485

Synonyms

OV4485

Accession

CVCL_9T21

Resource Identification Initiative

To cite this cell line use: OV-4485 (RRID:CVCL_9T21)

Comments

Doubling time: 1.85 +- 0.29 days (PubMed=26622941).
Omics: Genomics; Whole exome sequencing.
Omics: Variations; SNP array analysis.
Miscellaneous: STR profile from personal communication of Mes-Masson, Anne-Marie.
Derived from site: Metastatic; Ascites; UBERON=UBERON_0007795.

Sequence variations

Mutation; HGNC; HGNC:1100; BRCA1; Simple; c.4485-1G>T; ClinVar=VCV000246501; Zygosity=Unspecified; Note=Splice acceptor mutation (PubMed=26622941).
Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg273His (c.818G>A); ClinVar=VCV000012366; Zygosity=Unspecified (PubMed=26622941).

Disease

BRCA1 syndrome (NCIt: C36100)
High grade ovarian serous adenocarcinoma (NCIt: C105555)
Hereditary breast and ovarian cancer syndrome (ORDO: Orphanet_145)

Species of origin

Homo sapiens (Human) (NCBI Taxonomy: 9606)

Sex of cell

Female

Age at sampling

55Y

Category

Cancer cell line

STR profile

Source(s): Direct_author_submission

Markers:

Amelogenin	X
CSF1PO	10,12
D5S818	11,12
D7S820	11
D13S317	11
D16S539	12
D21S11	28,29
TH01	6
TPOX	8,11
vWA	15,17

Publications

PubMed=26622941; DOI=10.18632/genesandcancer.76; PMCID=PMC4633166
Hubert Fleury, Laudine Communal, Euridice Carmona, Lise Portelance, Suzanna L. Arcand, Kurosh Rahimi, Patricia N. Tonin, Diane Michele Provencher, Anne-Marie Mes-Masson;
Novel high-grade serous epithelial ovarian cancer cell lines that reflect the molecular diversity of both the sporadic and hereditary disease.
Genes Cancer 6:378-398(2015)

Cross-references

Cell line collections (Providers)

CancerTools; 161788

Cell line databases/resources

cancercelllines; CVCL_9T21

Encyclopedic resources

Wikidata; Q54936831

Entry history

Entry creation

23-Feb-2016

Last entry update

10-Apr-2025

Version number