Cellosaurus cell line SAML-2 (CVCL

Cellosaurus SAML-2 (CVCL_9998)

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Cell line name

SAML-2

Accession

CVCL_9998

Resource Identification Initiative

To cite this cell line use: SAML-2 (RRID:CVCL_9998)

Comments

Characteristics: CSF2 dependent.
Donor information: Originally the patient was suffering from Hodgkin lymphoma.
Derived from site: In situ; Bone marrow; UBERON=UBERON_0002371.

Sequence variations

Gene deletion; HGNC; HGNC:11998; TP53; Zygosity=Heterozygous (PubMed=12759925).
Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg273His (c.818G>A); ClinVar=VCV000012366; Zygosity=Heterozygous (PubMed=12759925).

Disease

Therapy-related acute myeloid leukemia (NCIt: C8252)
Therapy related acute myeloid leukemia and myelodysplastic syndrome (ORDO: Orphanet_86846)

Species of origin

Homo sapiens (Human) (NCBI Taxonomy: 9606)

Sex of cell

Male

Age at sampling

42Y

Category

Cancer cell line

STR profile

Source(s): ATCC=CRL-2840

Markers:

Amelogenin	X,Y
CSF1PO	10,12
D5S818	11
D7S820	8,11
D13S317	11,12
D16S539	9
TH01	7,9
TPOX	11
vWA	17,19

Publications

PubMed=12759925; DOI=10.1002/gcc.10200
Turid Knutsen, Svetlana Pack, Maria Petropavlovskaja, Hesed Maria Padilla-Nash, Clement Knight, Lyn A. Mickley, Thomas Ried, Patrick C. Elwood, Susan J. Roberts;
Cytogenetic, spectral karyotyping, fluorescence in situ hybridization, and comparative genomic hybridization characterization of two new secondary leukemia cell lines with 5q deletions, and MYC and MLL amplification.
Genes Chromosomes Cancer 37:270-281(2003)

PubMed=14671638; DOI=10.1038/sj.leu.2403236
Hans Gunther Drexler, Hilmar Quentmeier, Roderick A.F. MacLeod;
Malignant hematopoietic cell lines: in vitro models for the study of MLL gene alterations.
Leukemia 18:227-232(2004)

PubMed=29533902; DOI=10.1515/hsz-2017-0321
Hans Gunther Drexler, Claudia Pommerenke, Sonja Eberth, Stefan Nagel;
Hodgkin lymphoma cell lines: to separate the wheat from the chaff.
Biol. Chem. 399:511-523(2018)

Cross-references

Cell line collections (Providers)

ATCC; CRL-2840 - Discontinued

Cell line databases/resources

cancercelllines; CVCL_9998
SKY/M-FISH/CGH; 2854

Encyclopedic resources

Wikidata; Q54952089

Polymorphism and mutation databases

Cosmic; 975298

Entry history

Entry creation

06-Jun-2012

Last entry update

19-Dec-2024

Version number