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Cellosaurus ZK-58 (CVCL_9920)

[Text version]
Cell line name ZK-58
Synonyms ZK58; HOS 58
Accession CVCL_9920
Resource Identification Initiative To cite this cell line use: ZK-58 (RRID:CVCL_9920)
Comments Characteristics: Established from a nude mice xenograft (PubMed=9674117).
Doubling time: ~72 hours (PubMed=21519327).
Omics: Transcriptomics; Microarray.
Omics: Variations; SNP array analysis.
Derived from site: In situ; Bone, leg; UBERON=UBERON_0005893.
Sequence variations
Disease Osteosarcoma (NCIt: C9145)
Osteosarcoma (ORDO: Orphanet_668)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 21Y
Category Cancer cell line
STR profile Source(s): PubMed=19787792

Markers:
AmelogeninX,Y
D2S133825
D3S135816
D5S81811
D8S117913,14
D16S53911
D18S5115,18
D19S43312,14
D21S1129,30.2
FGA24
SE3324.2
TH016
TPOX8
vWA17,18

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Publications

PubMed=9674117; DOI=10.1046/j.1432-0436.1998.6320081.x
Heide Siggelkow, Christopher Niedhart, Wiebke Kurre, Angela Ihbe, Andreas Schulz, Michael John Atkinson, Michael Hufner;
In vitro differentiation potential of a new human osteosarcoma cell line (HOS 58).
Differentiation 63:81-91(1998)

PubMed=12645653; DOI=10.1016/S0165-4608(02)00685-4
Toshifumi Ozaki, Thomas Neumann, Daniel H. Wai, Karl-Ludwig Schaefer, Frans van Valen, Norbert Lindner, Christina Scheel, Werner Boecker, Winfried Winkelmann, Barbara Dockhorn-Dworniczak, Jurgen Horst, Christopher Poremba;
Chromosomal alterations in osteosarcoma cell lines revealed by comparative genomic hybridization and multicolor karyotyping.
Cancer Genet. Cytogenet. 140:145-152(2003)

PubMed=15150091; DOI=10.1158/0008-5472.CAN-03-0809
Karl-Ludwig Schaefer, Kristin Brachwitz, Daniel H. Wai, Yvonne Braun, Raihanatou Diallo, Eberhard Korsching, Martin Eisenacher, Reinhard Voss, Frans van Valen, Claudia Baer, Barbara Selle ...Show all 18 authors... , Laura Spahn, Shuen-Kuei Liao, Kevin A.W. Lee, Pancras Cornelis Wilhelmus Hogendoorn, Guido Reifenberger, Helmut Erich Gabbert, Christopher Poremba; Show fewer authors
Expression profiling of t(12;22) positive clear cell sarcoma of soft tissue cell lines reveals characteristic up-regulation of potential new marker genes including ERBB3.
Cancer Res. 64:3395-3405(2004)

PubMed=19787792; DOI=10.1002/gcc.20717
Laura Ottaviano, Karl-Ludwig Schaefer, Melanie Gajewski, Wolfgang Huckenbeck, Stefan E. Baldus, Uwe Rogel, Carlos Mackintosh, Enrique de Alava, Ola Myklebost, Stine Henrichson Kresse, Leonardo Andres Meza-Zepeda ...Show all 18 authors... , Massimo Serra, Anne-Marie Cleton-Jansen, Pancras Cornelis Wilhelmus Hogendoorn, Horst Buerger, Thomas Aigner, Helmut Erich Gabbert, Christopher Poremba; Show fewer authors
Molecular characterization of commonly used cell lines for bone tumor research: a trans-European EuroBoNet effort.
Genes Chromosomes Cancer 49:40-51(2010)

PubMed=21519327; DOI=10.1038/labinvest.2011.72
Alexander B. Mohseny, Isidro Machado, Yong-Ping Cai, Karl-Ludwig Schaefer, Massimo Serra, Pancras Cornelis Wilhelmus Hogendoorn, Antonio Llombart-Bosch, Anne-Marie Cleton-Jansen;
Functional characterization of osteosarcoma cell lines provides representative models to study the human disease.
Lab. Invest. 91:1195-1205(2011)

PubMed=23144859; DOI=10.1371/journal.pone.0048262; PMCID=PMC3492335
Stine Henrichson Kresse, Halfdan Rydbeck, Magne Skarn, Heidi Maria Namlos, Ana Heslanyeth Barragan-Polania, Anne-Marie Cleton-Jansen, Massimo Serra, Knut Liestol, Pancras Cornelis Wilhelmus Hogendoorn, Eivind Hovig, Ola Myklebost, Leonardo Andres Meza-Zepeda;
Integrative analysis reveals relationships of genetic and epigenetic alterations in osteosarcoma.
PLoS ONE 7:e48262.1-e48262.20(2012)

Cross-references
Cell line databases/resources cancercelllines; CVCL_9920
Encyclopedic resources Wikidata; Q54995932
Gene expression databases GEO; GSM879224
Polymorphism and mutation databases Cosmic; 1529906
IARC_TP53; 27033
Progenetix; CVCL_9920
Entry history
Entry creation06-Jun-2012
Last entry update10-Apr-2025
Version number19