Cellosaurus logo
expasy logo

Cellosaurus XTC.UC1 (CVCL_9916)

[Text version]
Cell line name XTC.UC1
Synonyms XTC-UC1; XTC-1; XTC1; XTC
Accession CVCL_9916
Resource Identification Initiative To cite this cell line use: XTC.UC1 (RRID:CVCL_9916)
Comments Characteristics: Has a near-homozygous genome (NHG) (PubMed=29066502).
Doubling time: 103 +- 6.7 hours (PubMed=9669284).
Omics: Mitochondrial genome sequenced.
Miscellaneous: STR profile from personal communication of Marlow L.A.
Derived from site: Metastatic; Breast; UBERON=UBERON_0000310.
Sequence variations
  • Mutation; HGNC; 7427; MT-CYB; Simple; p.Glu271Lys (m.15557G>A); ClinVar=VCV000693906; Zygosity=Heteroplasmic; Note=In 70.3% (PubMed=16778181).
  • Mutation; HGNC; 7455; MT-ND1; Simple; p.Gly101Ter (m.3571insC); Zygosity=Heteroplasmic; Note=In 94.3% (PubMed=16778181).
  • Mutation; HGNC; 8607; PRKN; Simple; p.Val380Leu (c.1138G>C); ClinVar=VCV000041221; Zygosity=Homozygous; Note=Germline (PubMed=26354775).
  • Mutation; HGNC; 11998; TP53; Simple; p.Pro151Thr (c.451C>A); ClinVar=VCV000012369; Zygosity=Homozygous (PubMed=31443247).
Disease Thyroid gland Hurthle cell carcinoma (NCIt: C4946)
Differentiated thyroid carcinoma (ORDO: Orphanet_146)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Age at sampling 63Y
Category Cancer cell line
STR profile Source(s): Direct_author_submission


Run an STR similarity search on this cell line

PubMed=9669284; DOI=10.1089/thy.1998.8.475
Zielke A., Tezelman S., Jossart G.H., Wong M.G., Siperstein A.E., Duh Q.-Y., Clark O.H.
Establishment of a highly differentiated thyroid cancer cell line of Hurthle cell origin.
Thyroid 8:475-483(1998)

PubMed=11349830; DOI=10.1089/10507250152039055
Savagner F., Chevrollier A., Loiseau D., Morgan C., Reynier P., Clark O.H., Stepien G., Malthiery Y.
Mitochondrial activity in XTC.UC1 cells derived from thyroid oncocytoma.
Thyroid 11:327-333(2001)

PubMed=16646677; DOI=10.1089/thy.2006.16.325
Stankov K., Biondi A., D'Aurelio M., Gasparre G., Falasca A., Romeo G., Lenaz G.
Mitochondrial activities of a cell line derived from thyroid Hurthle cell tumors.
Thyroid 16:325-331(2006)

PubMed=16778181; DOI=10.1158/0008-5472.CAN-06-0171
Bonora E., Porcelli A.M., Gasparre G., Biondi A., Ghelli A., Carelli V., Baracca A., Tallini G., Martinuzzi A., Lenaz G., Rugolo M., Romeo G.
Defective oxidative phosphorylation in thyroid oncocytic carcinoma is associated with pathogenic mitochondrial DNA mutations affecting complexes I and III.
Cancer Res. 66:6087-6096(2006)

PubMed=17725429; DOI=10.1089/thy.2007.0097
Meireles A.M., Preto A., Rocha A.S., Rebocho A.P., Maximo V., Pereira-Castro I., Moreira S., Feijao T., Botelho T., Marques R., Trovisco V., Cirnes L., Alves C., Velho S., Soares P., Sobrinho-Simoes M.
Molecular and genotypic characterization of human thyroid follicular cell carcinoma-derived cell lines.
Thyroid 17:707-715(2007)

PubMed=19087340; DOI=10.1186/1471-2407-8-371
Ribeiro F.R., Meireles A.M., Rocha A.S., Teixeira M.R.
Conventional and molecular cytogenetics of human non-medullary thyroid carcinoma: characterization of eight cell line models and review of the literature on clinical samples.
BMC Cancer 8:371.1-371.11(2008)

PubMed=26354775; DOI=10.1093/carcin/bgv122
Lee J., Ham S., Lee M.H., Kim S.J., Park J.H., Lee S.E., Chang J.Y., Joung K.H., Kim T.Y., Kim J.M., Sul H.J., Kweon G.R., Jo Y.S., Kim K.S., Shong Y.K., Gasparre G., Chung J.K., Porcelli A.M., Shong M.
Dysregulation of Parkin-mediated mitophagy in thyroid Hurthle cell tumors.
Carcinogenesis 36:1407-1418(2015)

PubMed=29066502; DOI=10.1530/ERC-17-0288
Corver W.E., Demmers J., Oosting J., Sahraeian S., Boot A., Ruano D., van Wezel T., Morreau H.
ROS-induced near-homozygous genomes in thyroid cancer.
Endocr. Relat. Cancer 25:83-97(2018)

PubMed=31443247; DOI=10.3390/cancers11081185
Aydemirli M.D., Corver W.E., Beuk R., Roepman P., Solleveld-Westerink N., van Wezel T., Kapiteijn E.H.W., Morreau H.
Targeted treatment options of recurrent radioactive iodine refractory Hurthle cell cancer.
Cancers (Basel) 11:1185.1-1185.16(2019)

Cell line databases/resources cancercelllines; CVCL_9916
Encyclopedic resources Wikidata; Q54995073
Polymorphism and mutation databases Cosmic; 1084281
Cosmic; 1162844
Cosmic; 2036689
Cosmic; 2328761
Entry history
Entry creation06-Jun-2012
Last entry update05-Oct-2023
Version number21