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Cellosaurus XTC.UC1 (CVCL_9916)

[Text version]
Cell line name XTC.UC1
Synonyms XTC-UC1; XTC-1; XTC1; XTC
Accession CVCL_9916
Resource Identification Initiative To cite this cell line use: XTC.UC1 (RRID:CVCL_9916)
Comments Characteristics: Has a near-homozygous genome (NHG) (PubMed=29066502).
Doubling time: 103 +- 6.7 hours (PubMed=9669284).
Omics: Genomics; Mitochondrial genome sequencing.
Omics: Metabolomics.
Miscellaneous: STR profile from personal communication of Marlow, Laura A.
Derived from site: Metastatic; Breast; UBERON=UBERON_0000310.
Sequence variations
  • Mutation; HGNC; HGNC:7427; MT-CYB; Simple; p.Glu271Lys (m.15557G>A); ClinVar=VCV000693906; Zygosity=Heteroplasmic; Note=In 70.3% (PubMed=16778181).
  • Mutation; HGNC; HGNC:7455; MT-ND1; Simple; p.Gly101Ter (m.3571insC); Zygosity=Heteroplasmic; Note=In 94.3% (PubMed=16778181).
  • Mutation; HGNC; HGNC:8607; PRKN; Simple; p.Val380Leu (c.1138G>C); ClinVar=VCV000041221; Zygosity=Homozygous; Note=Germline (PubMed=26354775).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Pro151Thr (c.451C>A); ClinVar=VCV000012369; Zygosity=Homozygous (PubMed=31443247).
Disease Thyroid gland Hurthle cell carcinoma (NCIt: C4946)
Differentiated thyroid carcinoma (ORDO: Orphanet_146)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Age at sampling 63Y
Category Cancer cell line
STR profile Source(s): Direct_author_submission

Markers:
AmelogeninX
CSF1PO11
D3S135815
D5S81811,12
D7S82011
D8S117912
D13S31712
D18S5113,17
FGA24.2
TH019.3
TPOX8
vWA18

Run an STR similarity search on this cell line
Publications

PubMed=9669284; DOI=10.1089/thy.1998.8.475
Andreas Zielke, Serdar Tezelman, Gregg H. Jossart, Mariwil G. Wong, Allan E. Siperstein, Quan-Yang Duh, Orlo Herrick Clark;
Establishment of a highly differentiated thyroid cancer cell line of Hurthle cell origin.
Thyroid 8:475-483(1998)

PubMed=11349830; DOI=10.1089/10507250152039055
Frederique Savagner, Arnaud Chevrollier, Dominique Loiseau, Claudia Morgan, Pascal Reynier, Orlo Herrick Clark, Georges Stepien, Yves Malthiery;
Mitochondrial activity in XTC.UC1 cells derived from thyroid oncocytoma.
Thyroid 11:327-333(2001)

PubMed=16646677; DOI=10.1089/thy.2006.16.325
Karmen Stankov, Annalisa Biondi, Marilena D'Aurelio, Giuseppe Gasparre, Anna Falasca, Giovanni Romeo, Giorgio Lenaz;
Mitochondrial activities of a cell line derived from thyroid Hurthle cell tumors.
Thyroid 16:325-331(2006)

PubMed=16778181; DOI=10.1158/0008-5472.CAN-06-0171
Elena Bonora, Anna Maria Porcelli, Giuseppe Gasparre, Annalisa Biondi, Anna Ghelli, Valerio Carelli, Alessandra Baracca, Giovanni Tallini, Andrea Martinuzzi, Giorgio Lenaz, Michela Rugolo, Giovanni Romeo;
Defective oxidative phosphorylation in thyroid oncocytic carcinoma is associated with pathogenic mitochondrial DNA mutations affecting complexes I and III.
Cancer Res. 66:6087-6096(2006)

PubMed=17725429; DOI=10.1089/thy.2007.0097
Ana Margarida Meireles, Ana Preto, Ana Sofia Rocha, Ana Paula Rebocho, Valdemar Maximo, Isabel Pereira-Castro, Severina Moreira, Talia Feijao, Tiago Botelho, Ricardo Marques, Vitor Trovisco ...Show all 16 authors... , Luis Cirnes, Cintia Alves, Sergia Velho, Paula Soares, Manuel Sobrinho-Simoes; Show fewer authors
Molecular and genotypic characterization of human thyroid follicular cell carcinoma-derived cell lines.
Thyroid 17:707-715(2007)

PubMed=19087340; DOI=10.1186/1471-2407-8-371; PMCID=PMC2651892
Franclim Ricardo Ribeiro, Ana Margarida Meireles, Ana Sofia Rocha, Manuel R. Teixeira;
Conventional and molecular cytogenetics of human non-medullary thyroid carcinoma: characterization of eight cell line models and review of the literature on clinical samples.
BMC Cancer 8:371.1-371.11(2008)

PubMed=26354775; DOI=10.1093/carcin/bgv122
Junguee Lee, Sujin Ham, Min Hee Lee, Soung Jung Kim, Ji Hoon Park, Seong Eun Lee, Joon Young Chang, Kyong Hye Joung, Tae Yong Kim, Jin Man Kim, Hae Joung Sul ...Show all 19 authors... , Gi Ryang Kweon, Young Suk Jo, Koon Soon Kim, Young Kee Shong, Giuseppe Gasparre, Jong Kyeong Chung, Anna Maria Porcelli, Minho Shong; Show fewer authors
Dysregulation of parkin-mediated mitophagy in thyroid Hurthle cell tumors.
Carcinogenesis 36:1407-1418(2015)

PubMed=29066502; DOI=10.1530/ERC-17-0288
Willem E. Corver, Joris Demmers, Jan Oosting, Shima Sahraeian, Arnoud Boot, Dina Ruano, Tom van Wezel, Hans Morreau;
ROS-induced near-homozygous genomes in thyroid cancer.
Endocr. Relat. Cancer 25:83-97(2018)

PubMed=31443247; DOI=10.3390/cancers11081185; PMCID=PMC6721552
Mehtap Derya Aydemirli, Willem E. Corver, Ruben Beuk, Paul Roepman, Nienke Solleveld-Westerink, Tom van Wezel, Ellen H.W. Kapiteijn, Hans Morreau;
Targeted treatment options of recurrent radioactive iodine refractory Hurthle cell cancer.
Cancers (Basel) 11:1185.1-1185.16(2019)

PubMed=36599897; DOI=10.1038/s41598-023-27461-2; PMCID=PMC9813134
Tomomi Kurashige, Mika Shimamura, Koichiro Hamada, Michiko Matsuse, Norisato Mitsutake, Yuji Nagayama;
Characterization of metabolic reprogramming by metabolomics in the oncocytic thyroid cancer cell line XTC.UC1.
Sci. Rep. 13:149.1-149.11(2023)

Cross-references
Cell line databases/resources cancercelllines; CVCL_9916
Encyclopedic resources Wikidata; Q54995073
Polymorphism and mutation databases Cosmic; 1084281
Cosmic; 1162844
Cosmic; 2036689
Cosmic; 2328761
Entry history
Entry creation06-Jun-2012
Last entry update10-Apr-2025
Version number24