Cellosaurus logo
expasy logo

Cellosaurus VM-CUB-3 (CVCL_9830)

[Text version]
Cell line name VM-CUB-3
Synonyms VM-CUB3; VMCUB-3; VMCUB3; VMCub3; VM Cub 3; VM-CUB-III; VMCUBIII; CUB III; CUBIII
Accession CVCL_9830
Resource Identification Initiative To cite this cell line use: VM-CUB-3 (RRID:CVCL_9830)
Comments Problematic cell line: Partially contaminated. Some stocks are contaminated by VM-CUB-1 (PubMed=3708594; PubMed=20143388). Although PubMed=26621286 shows it to be different from VM-CUB-1.
Part of: BLA-40 bladder carcinoma cell line panel.
Part of: UBC-40 urothelial bladder cancer cell line index.
Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00102.
Doubling time: 26 hours (PubMed=3708594).
Omics: Genomics; Whole exome sequencing.
Omics: Transcriptomics; Microarray.
Omics: Variations; CNV analysis.
Omics: Variations; SNP array analysis.
Derived from site: In situ; Urinary bladder; UBERON=UBERON_0001255.
Sequence variations
  • Mutation; HGNC; HGNC:11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (PubMed=24035680).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Pro278Leu (c.833C>T); ClinVar=VCV000232497; Zygosity=Homozygous (PubMed=27270441).
Disease Bladder carcinoma (NCIt: C4912)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Age at sampling Age unspecified
Category Cancer cell line
STR profile Source(s): PubMed=27270441

Markers:
AmelogeninX
CSF1PO12
D5S81811
D7S8208,9
D13S3179,12
D16S53912
TH019.3
TPOX8
vWA16

Run an STR similarity search on this cell line
Web pages Info; ICLAC; -; https://iclac.org/wp-content/uploads/Cross-Contaminations_v13_distribution.xlsx
Info; Synapse; Bladder Cancer exome; https://www.synapse.org/Synapse:syn4970200
Publications

PubMed=571047
Jorgen Fogh;
Cultivation, characterization, and identification of human tumor cells with emphasis on kidney, testis, and bladder tumors.
Natl. Cancer Inst. Monogr. 49:5-9(1978)

PubMed=6244232
Richard D. Williams;
Human urologic cancer cell lines.
Invest. Urol. 17:359-363(1980)

PubMed=7459858
Monique Rousset, Alain Zweibaum, Jorgen Fogh;
Presence of glycogen and growth-related variations in 58 cultured human tumor cell lines of various tissue origins.
Cancer Res. 41:1165-1170(1981)

PubMed=6220172
Nicholas C. Dracopoli, Jorgen Fogh;
Polymorphic enzyme analysis of cultured human tumor cell lines.
J. Natl. Cancer Inst. 70:469-476(1983)

PubMed=3518877; DOI=10.3109/07357908609038260
Jorgen Fogh;
Human tumor lines for cancer research.
Cancer Invest. 4:157-184(1986)

PubMed=3708594
John R.W. Masters, Peter J. Hepburn, Lawrence Walker, Wilma J. Highman, Ludwik K. Trejdosiewicz, Susan Povey, Mohamed Parkar, Bridget T. Hill, Peter N. Riddle, Leonard Maurice Franks;
Tissue culture model of transitional cell carcinoma: characterization of twenty-two human urothelial cell lines.
Cancer Res. 46:3630-3636(1986)

PubMed=15846775; DOI=10.1002/gcc.20166
Sarah V. Williams, Jacqui Adams, Jane Coulter, Brenda M. Summersgill, Janet M. Shipley, Margaret A. Knowles;
Assessment by M-FISH of karyotypic complexity and cytogenetic evolution in bladder cancer in vitro.
Genes Chromosomes Cancer 43:315-328(2005)

PubMed=16885334; DOI=10.1158/0008-5472.CAN-06-1182
Elena Lopez-Knowles, Silvia Hernandez, Nuria Malats, Manolis Kogevinas, Josep Lloreta, Alfredo Carrato, Adonina Tardon, Consol Serra, Francisco X. Real;
PIK3CA mutations are an early genetic alteration associated with FGFR3 mutations in superficial papillary bladder tumors.
Cancer Res. 66:7401-7404(2006)

PubMed=20143388; DOI=10.1002/ijc.25242
Amanda Capes-Davis, George Theodosopoulos, Isobel Atkin, Hans Gunther Drexler, Arihiro Kohara, Roderick A.F. MacLeod, John R.W. Masters, Yukio Nakamura, Yvonne A. Reid, Roger Robert Reddel, Robert Ian Freshney;
Check your cultures! A list of cross-contaminated or misidentified cell lines.
Int. J. Cancer 127:1-8(2010)

PubMed=24367658; DOI=10.1371/journal.pone.0084411; PMCID=PMC3867501
Rebecca L. Ross, Julie E. Burns, Claire F. Taylor, Paul Mellor, Deborah H. Anderson, Margaret A. Knowles;
Identification of mutations in distinct regions of p85 alpha in urothelial cancer.
PLoS ONE 8:e84411.1-e84411.11(2013)

PubMed=24035680; DOI=10.1016/j.eururo.2013.08.057
Carolyn D. Hurst, Fiona M. Platt, Margaret A. Knowles;
Comprehensive mutation analysis of the TERT promoter in bladder cancer and detection of mutations in voided urine.
Eur. Urol. 65:367-369(2014)

PubMed=25997541; DOI=10.1186/s12864-015-1450-3; PMCID=PMC4470036
Julie Earl, Daniel Rico, Enrique Carrillo-de-Santa-Pau, Benjamin Rodriguez-Santiago, Marinela Mendez-Pertuz, Herbert Auer, Gonzalo Gomez, Herbert Barton Grossman, David G. Pisano, Wolfgang A. Schulz, Luis A. Perez-Jurado ...Show all 16 authors... , Alfredo Carrato, Dan Theodorescu, Stephen Jacob Chanock, Alfonso Valencia, Francisco X. Real; Show fewer authors
The UBC-40 Urothelial Bladder Cancer cell line index: a genomic resource for functional studies.
BMC Genomics 16:403.1-403.16(2015)

PubMed=26621286; DOI=10.1186/s12864-015-2227-4; PMCID=PMC4681452
Julie Earl, Daniel Rico, Enrique Carrillo-de-Santa-Pau, Benjamin Rodriguez-Santiago, Marinela Mendez-Pertuz, Herbert Auer, Gonzalo Gomez, Herbert Barton Grossman, David G. Pisano, Wolfgang A. Schulz, Luis A. Perez-Jurado ...Show all 16 authors... , Alfredo Carrato, Dan Theodorescu, Stephen Jacob Chanock, Alfonso Valencia, Francisco X. Real; Show fewer authors
Erratum to: The UBC-40 Urothelial Bladder Cancer cell line index: a genomic resource for functional studies.
BMC Genomics 16:1019.1-1019.2(2015)

PubMed=27270441; DOI=10.1038/onc.2016.172; PMCID=PMC5140783
Michael L. Nickerson, Nicolle Witte, Kate McGee Im, Sevilay Turan, Charles R. Owens, Kevin Misner, Shirley X. Tsang, Zhi-Ming Cai, Sen Wu, Michael Dean, James C. Costello, Dan Theodorescu;
Molecular analysis of urothelial cancer cell lines for modeling tumor biology and drug response.
Oncogene 36:35-46(2017)

PubMed=29732388; DOI=10.3233/BLC-180167; PMCID=PMC5929350
Tahlita C.M. Zuiverloon, Florus C. de Jong, James C. Costello, Dan Theodorescu;
Systematic review: characteristics and preclinical uses of bladder cancer cell lines.
Bladder Cancer 4:169-183(2018)

Cross-references
Cell line collections (Providers) ATCC; HTB-6 - Discontinued
Cell line databases/resources cancercelllines; CVCL_9830
Biological sample resources BioSample; SAMN03152040
Encyclopedic resources Wikidata; Q54993215
Gene expression databases GEO; GSM136263
GEO; GSM1574580
Polymorphism and mutation databases Cosmic; 925826
Cosmic; 1016888
Cosmic; 1046679
Cosmic; 1285135
Cosmic; 1285994
Cosmic; 1938425
Cosmic; 2050472
Cosmic; 2057463
Cosmic; 2212697
Cosmic; 2444225
IARC_TP53; 6611
Entry history
Entry creation06-Jun-2012
Last entry update10-Apr-2025
Version number33