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Cellosaurus MGH-U3 (CVCL_9827)

[Text version]
Cell line name MGH-U3
Synonyms MGHU3; MG-HU-3; MGH-U3 (RN); RN
Accession CVCL_9827
Resource Identification Initiative To cite this cell line use: MGH-U3 (RRID:CVCL_9827)
Comments Part of: BLA-40 bladder carcinoma cell line panel.
Part of: UBC-40 urothelial bladder cancer cell line index.
Population: Caucasian.
Omics: Genomics; Whole exome sequencing.
Omics: Transcriptomics; Microarray.
Omics: Variations; CNV analysis.
Omics: Variations; SNP array analysis.
Derived from site: In situ; Urinary bladder; UBERON=UBERON_0001255.
Sequence variations
  • Mutation; HGNC; HGNC:391; AKT1; Simple; p.Glu17Lys (c.49G>A); ClinVar=VCV000013983; Zygosity=Unspecified (PubMed=19802009).
  • Mutation; HGNC; HGNC:13726; KMT2C; Simple; p.Arg4139Ter (c.12415C>T); ClinVar=VCV000975272; Zygosity=Homozygous (PubMed=27270441).
  • Mutation; HGNC; HGNC:11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (PubMed=24035680).
Disease Bladder carcinoma (NCIt: C4912)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 76Y
Category Cancer cell line
STR profile Source(s): PubMed=27270441

Markers:
AmelogeninX,Y
CSF1PO11,12
D5S81811,13
D7S8208
D13S31712
D16S5399
TH017,8
TPOX8,12
vWA14

Run an STR similarity search on this cell line
Web pages Info; Synapse; Bladder Cancer exome; https://www.synapse.org/Synapse:syn4970200
Publications

PubMed=4027986
Chi-Wei Lin, Julia C. Lin, George Russell Prout Jr.;
Establishment and characterization of four human bladder tumor cell lines and sublines with different degrees of malignancy.
Cancer Res. 45:5070-5079(1985)

PubMed=8873383; DOI=10.1007/BF00295899
Walter M. Stadler, Olufunmilayo I. Olopade;
The 9p21 region in bladder cancer cell lines: large homozygous deletion inactivate the CDKN2, CDKN2B and MTAP genes.
Urol. Res. 24:239-244(1996)

PubMed=16885334; DOI=10.1158/0008-5472.CAN-06-1182
Elena Lopez-Knowles, Silvia Hernandez, Nuria Malats, Manolis Kogevinas, Josep Lloreta, Alfredo Carrato, Adonina Tardon, Consol Serra, Francisco X. Real;
PIK3CA mutations are an early genetic alteration associated with FGFR3 mutations in superficial papillary bladder tumors.
Cancer Res. 66:7401-7404(2006)

PubMed=19802009; DOI=10.1038/onc.2009.315
Jonathan M. Askham, Fiona M. Platt, Philip A. Chambers, Helen Snowden, Claire F. Taylor, Margaret A. Knowles;
AKT1 mutations in bladder cancer: identification of a novel oncogenic mutation that can co-operate with E17K.
Oncogene 29:150-155(2010)

PubMed=23401075; DOI=10.1002/path.4176
Ya-Nan Guo, Yvonne Chekaluk, Jian-Ming Zhang, Jin-Yan Du, Nathanael S. Gray, Chin-Lee Wu, David Joseph Kwiatkowski;
TSC1 involvement in bladder cancer: diverse effects and therapeutic implications.
J. Pathol. 230:17-27(2013)

PubMed=24367658; DOI=10.1371/journal.pone.0084411; PMCID=PMC3867501
Rebecca L. Ross, Julie E. Burns, Claire F. Taylor, Paul Mellor, Deborah H. Anderson, Margaret A. Knowles;
Identification of mutations in distinct regions of p85 alpha in urothelial cancer.
PLoS ONE 8:e84411.1-e84411.11(2013)

PubMed=24018021; DOI=10.1016/j.eururo.2013.08.052
Yves Allory, Willemien Beukers, Ana Sagrera, Marta Flandez, Miriam Marques, Mirari Marquez, Kirstin A. van der Keur, Lars Dyrskjot, Irene Lurkin, Marcel Vermeij, Alfredo Carrato ...Show all 24 authors... , Josep Lloreta, Jose A. Lorente, Enrique Carrillo-de-Santa-Pau, Roy G. Masius, Manolis Kogevinas, Ewout Willem Steyerberg, Angela A.G. van Tilborg, Cheno Abas, Torben Falck Orntoft, Tahlita C.M. Zuiverloon, Nuria Malats, Ellen C. Zwarthoff, Francisco X. Real; Show fewer authors
Telomerase reverse transcriptase promoter mutations in bladder cancer: high frequency across stages, detection in urine, and lack of association with outcome.
Eur. Urol. 65:360-366(2014)

PubMed=24035680; DOI=10.1016/j.eururo.2013.08.057
Carolyn D. Hurst, Fiona M. Platt, Margaret A. Knowles;
Comprehensive mutation analysis of the TERT promoter in bladder cancer and detection of mutations in voided urine.
Eur. Urol. 65:367-369(2014)

PubMed=25997541; DOI=10.1186/s12864-015-1450-3; PMCID=PMC4470036
Julie Earl, Daniel Rico, Enrique Carrillo-de-Santa-Pau, Benjamin Rodriguez-Santiago, Marinela Mendez-Pertuz, Herbert Auer, Gonzalo Gomez, Herbert Barton Grossman, David G. Pisano, Wolfgang A. Schulz, Luis A. Perez-Jurado ...Show all 16 authors... , Alfredo Carrato, Dan Theodorescu, Stephen Jacob Chanock, Alfonso Valencia, Francisco X. Real; Show fewer authors
The UBC-40 Urothelial Bladder Cancer cell line index: a genomic resource for functional studies.
BMC Genomics 16:403.1-403.16(2015)

PubMed=27270441; DOI=10.1038/onc.2016.172; PMCID=PMC5140783
Michael L. Nickerson, Nicolle Witte, Kate McGee Im, Sevilay Turan, Charles R. Owens, Kevin Misner, Shirley X. Tsang, Zhi-Ming Cai, Sen Wu, Michael Dean, James C. Costello, Dan Theodorescu;
Molecular analysis of urothelial cancer cell lines for modeling tumor biology and drug response.
Oncogene 36:35-46(2017)

PubMed=29732388; DOI=10.3233/BLC-180167; PMCID=PMC5929350
Tahlita C.M. Zuiverloon, Florus C. de Jong, James C. Costello, Dan Theodorescu;
Systematic review: characteristics and preclinical uses of bladder cancer cell lines.
Bladder Cancer 4:169-183(2018)

Cross-references
Cell line databases/resources cancercelllines; CVCL_9827
Anatomy/cell type resources BTO; BTO_0006287
Encyclopedic resources Wikidata; Q54905462
Gene expression databases GEO; GSM136255
GEO; GSM1374672
GEO; GSM1374673
GEO; GSM1574573
Polymorphism and mutation databases Cosmic; 928825
Cosmic; 1016886
Cosmic; 1068090
Cosmic; 1285123
Cosmic; 1286013
Cosmic; 1302361
Cosmic; 1927290
Cosmic; 1938479
Cosmic; 2037951
Cosmic; 2050458
Cosmic; 2686110
Entry history
Entry creation06-Jun-2012
Last entry update10-Apr-2025
Version number23