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Cellosaurus EcR-RKO/KLF4 (CVCL_9807)

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Cell line name EcR-RKO/KLF4
Accession CVCL_9807
Resource Identification Initiative To cite this cell line use: EcR-RKO/KLF4 (RRID:CVCL_9807)
Comments Genetic integration: Method=Transfection/transduction; Gene=MGI; MGI:1342287; Klf4.
Derived from site: In situ; Colon; UBERON=UBERON_0001155.
Sequence variations
  • Mutation; HGNC; HGNC:173; ACVR2A; Simple; p.Lys437Argfs*5 (c.1310delA); dbSNP=rs764719749; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.His1047Arg (c.3140A>G); ClinVar=VCV000013652; Zygosity=Unspecified (from parent cell line).
  • Mutation; HGNC; HGNC:11773; TGFBR2; Simple; p.Lys128Serfs*35 (c.383delA); ClinVar=VCV000477546; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11773; TGFBR2; Simple; p.Leu452Pro (c.1355T>C); ClinVar=VCV000930524; Zygosity=Heterozygous (from parent cell line).
Disease Colon carcinoma (NCIt: C4910)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0504 (RKO)
Sex of cell Sex unspecified
Age at sampling Age unspecified
Category Cancer cell line
Publications

PubMed=17017123; DOI=10.3727/000000006783991908; PMCID=PMC1626270
Erika M. Whitney, Amr M. Ghaleb, Xin-Ming Chen, Vincent W. Yang;
Transcriptional profiling of the cell cycle checkpoint gene kruppel-like factor 4 reveals a global inhibitory function in macromolecular biosynthesis.
Gene Expr. 13:85-96(2006)

Cross-references
Cell line databases/resources cancercelllines; CVCL_9807
Encyclopedic resources Wikidata; Q54831943
Experimental variables resources EFO; EFO_0002052
Entry history
Entry creation06-Jun-2012
Last entry update19-Dec-2024
Version number19