Cellosaurus logo
expasy logo

Cellosaurus WE-68 (CVCL_9717)

[Text version]
Cell line name WE-68
Synonyms WE 68; WE68
Accession CVCL_9717
Resource Identification Initiative To cite this cell line use: WE-68 (RRID:CVCL_9717)
Comments Omics: Transcriptomics; Microarray.
Omics: Variations; Array-based CGH.
Derived from site: In situ; Bone, fibula; UBERON=UBERON_0001446.
Sequence variations
Disease Ewing sarcoma (NCIt: C4817)
Ewing sarcoma (ORDO: Orphanet_319)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Originate from same individual CVCL_9718 ! WE-M1-68
CVCL_9719 ! WE-M2-68
Sex of cell Female
Age at sampling 19Y
Category Cancer cell line
STR profile Source(s): PubMed=19787792; PubMed=30879952

Markers:
AmelogeninX
CSF1PO12
D2S133819,20
D3S135815,18
D5S81811
D7S82010,12
D8S117910,15
D13S3179,11
D16S53911,12 (PubMed=19787792)
12 (PubMed=30879952)
D18S5111,18
D19S43314,15
D21S1130,31.2
FGA19,23
SE3319
TH016,8
TPOX8,10
vWA16,18

Run an STR similarity search on this cell line
Publications

PubMed=1320624; DOI=10.1007/BF01225268
Frans van Valen, Winfried Winkelmann, Herbert Jurgens;
Expression of functional Y1 receptors for neuropeptide Y in human Ewing's sarcoma cell lines.
J. Cancer Res. Clin. Oncol. 118:529-536(1992)

PubMed=8335680; DOI=10.1007/BF01372725
Frans van Valen, Winfried Winkelmann, Stefan Burdach, Ulrich Gobel, Herbert Jurgens;
Interferon gamma and tumour necrosis factor alpha induce a synergistic antiproliferative response in human Ewing's sarcoma cells in vitro.
J. Cancer Res. Clin. Oncol. 119:615-621(1993)

PubMed=8378080
Heinrich Kovar, Andreas Auinger, Gunhild Jug, Dave N.T. Aryee, Andreas Zoubek, Mechthild Salzer-Kuntschik, Helmut Gadner;
Narrow spectrum of infrequent p53 mutations and absence of MDM2 amplification in Ewing tumours.
Oncogene 8:2683-2690(1993)

PubMed=15150091; DOI=10.1158/0008-5472.CAN-03-0809
Karl-Ludwig Schaefer, Kristin Brachwitz, Daniel H. Wai, Yvonne Braun, Raihanatou Diallo, Eberhard Korsching, Martin Eisenacher, Reinhard Voss, Frans van Valen, Claudia Baer, Barbara Selle ...Show all 18 authors... , Laura Spahn, Shuen-Kuei Liao, Kevin A.W. Lee, Pancras Cornelis Wilhelmus Hogendoorn, Guido Reifenberger, Helmut Erich Gabbert, Christopher Poremba; Show fewer authors
Expression profiling of t(12;22) positive clear cell sarcoma of soft tissue cell lines reveals characteristic up-regulation of potential new marker genes including ERBB3.
Cancer Res. 64:3395-3405(2004)

PubMed=19787792; DOI=10.1002/gcc.20717
Laura Ottaviano, Karl-Ludwig Schaefer, Melanie Gajewski, Wolfgang Huckenbeck, Stefan E. Baldus, Uwe Rogel, Carlos Mackintosh, Enrique de Alava, Ola Myklebost, Stine Henrichson Kresse, Leonardo Andres Meza-Zepeda ...Show all 18 authors... , Massimo Serra, Anne-Marie Cleton-Jansen, Pancras Cornelis Wilhelmus Hogendoorn, Horst Buerger, Thomas Aigner, Helmut Erich Gabbert, Christopher Poremba; Show fewer authors
Molecular characterization of commonly used cell lines for bone tumor research: a trans-European EuroBoNet effort.
Genes Chromosomes Cancer 49:40-51(2010)

PubMed=21822310; DOI=10.1038/onc.2011.317
Carlos Mackintosh, Jose L. Ordonez, Daniel J. Garcia-Dominguez, Vicky Sevillano, Antonio Llombart-Bosch, Karoly Szuhai, Katia Scotlandi, Marco Alberghini, Raf Sciot, Friedl Sinnaeve, Pancras Cornelis Wilhelmus Hogendoorn ...Show all 17 authors... , Piero Picci, Sakari Knuutila, Uta Dirksen, Maria Debiec-Rychter, Karl-Ludwig Schaefer, Enrique de Alava; Show fewer authors
1q gain and CDT2 overexpression underlie an aggressive and highly proliferative form of Ewing sarcoma.
Oncogene 31:1287-1298(2012)

PubMed=26428435; DOI=10.1016/j.ejca.2015.08.020
Laurens G.L. Sand, Katia Scotlandi, Dagmar Berghuis, B. Ewa Snaar-Jagalska, Piero Picci, Thomas Schmidt, Karoly Szuhai, Pancras Cornelis Wilhelmus Hogendoorn;
CXCL14, CXCR7 expression and CXCR4 splice variant ratio associate with survival and metastases in Ewing sarcoma patients.
Eur. J. Cancer 51:2624-2633(2015)

PubMed=30879952; DOI=10.1016/j.ymthe.2019.02.014; PMCID=PMC6520468
Sareetha Kailayangiri, Bianca Altvater, Stefanie Lesch, Sebastian T. Balbach, Claudia Gottlich, Johanna Kuhnemundt, Jan-Henrik Mikesch, Sonja Schelhaas, Silke Jamitzky, Jutta Meltzer, Nicole Farwick ...Show all 20 authors... , Lea Greune, Maike Fluegge, Kornelius Kerl, Holger N. Lode, Nikolai Siebert, Ingo Muller, Heike Walles, Wolfgang Hartmann, Claudia Rossig; Show fewer authors
EZH2 inhibition in Ewing sarcoma upregulates GD2 expression for targeting with gene-modified T cells.
Mol. Ther. 27:933-946(2019)

Cross-references
Cell line databases/resources cancercelllines; CVCL_9717
Encyclopedic resources Wikidata; Q54993696
Experimental variables resources EFO; EFO_0002872
Gene expression databases GEO; GSM510016
Polymorphism and mutation databases IARC_TP53; 23651
Progenetix; CVCL_9717
Entry history
Entry creation06-Jun-2012
Last entry update10-Apr-2025
Version number24