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Cellosaurus RM-82 (CVCL_9714)

[Text version]
Cell line name RM-82
Synonyms RM 82; RM82
Accession CVCL_9714
Resource Identification Initiative To cite this cell line use: RM-82 (RRID:CVCL_9714)
Comments From: Van Valen F.; University of Munster; Munster; Germany.
Omics: Array-based CGH.
Derived from site: In situ; Bone, femur; UBERON=UBERON_0000981.
Sequence variations
Disease Ewing sarcoma (NCIt: C4817)
Ewing sarcoma (ORDO: Orphanet_319)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 9Y
Category Cancer cell line
STR profile Source(s): PubMed=19787792; PubMed=30879952

Markers:
AmelogeninX,Y
CSF1PO12
D2S133820,25
D3S135815,17
D5S81811
D7S8208,11
D8S117913
D13S31711,14
D16S53912
D18S5113,14
D19S43312,16
D21S1128,32.2
FGA18
SE3326.2
TH017,9.3
TPOX8
vWA16

Run an STR similarity search on this cell line
Publications

PubMed=1320624; DOI=10.1007/BF01225268
van Valen F., Winkelmann W., Jurgens H.
Expression of functional Y1 receptors for neuropeptide Y in human Ewing's sarcoma cell lines.
J. Cancer Res. Clin. Oncol. 118:529-536(1992)

PubMed=8335680; DOI=10.1007/BF01372725
van Valen F., Winkelmann W., Burdach S., Gobel U., Jurgens H.
Interferon gamma and tumour necrosis factor alpha induce a synergistic antiproliferative response in human Ewing's sarcoma cells in vitro.
J. Cancer Res. Clin. Oncol. 119:615-621(1993)

PubMed=8378080
Kovar H., Auinger A., Jug G., Aryee D.N.T., Zoubek A., Salzer-Kuntschik M., Gadner H.
Narrow spectrum of infrequent p53 mutations and absence of MDM2 amplification in Ewing tumours.
Oncogene 8:2683-2690(1993)

PubMed=15150091; DOI=10.1158/0008-5472.CAN-03-0809
Schaefer K.-L., Brachwitz K., Wai D.H., Braun Y., Diallo R., Korsching E., Eisenacher M., Voss R., van Valen F., Baer C., Selle B., Spahn L., Liao S.-K., Lee K.A.W., Hogendoorn P.C.W., Reifenberger G., Gabbert H.E., Poremba C.
Expression profiling of t(12;22) positive clear cell sarcoma of soft tissue cell lines reveals characteristic up-regulation of potential new marker genes including ERBB3.
Cancer Res. 64:3395-3405(2004)

PubMed=19787792; DOI=10.1002/gcc.20717
Ottaviano L., Schaefer K.-L., Gajewski M., Huckenbeck W., Baldus S.E., Rogel U., Mackintosh C., de Alava E., Myklebost O., Kresse S.H., Meza-Zepeda L.A., Serra M., Cleton-Jansen A.-M., Hogendoorn P.C.W., Buerger H., Aigner T., Gabbert H.E., Poremba C.
Molecular characterization of commonly used cell lines for bone tumor research: a trans-European EuroBoNet effort.
Genes Chromosomes Cancer 49:40-51(2010)

PubMed=21822310; DOI=10.1038/onc.2011.317
Mackintosh C., Ordonez J.L., Garcia-Dominguez D.J., Sevillano V., Llombart-Bosch A., Szuhai K., Scotlandi K., Alberghini M., Sciot R., Sinnaeve F., Hogendoorn P.C.W., Picci P., Knuutila S., Dirksen U., Debiec-Rychter M., Schaefer K.-L., de Alava E.
1q gain and CDT2 overexpression underlie an aggressive and highly proliferative form of Ewing sarcoma.
Oncogene 31:1287-1298(2012)

PubMed=26428435; DOI=10.1016/j.ejca.2015.08.020
Sand L.G.L., Scotlandi K., Berghuis D., Snaar-Jagalska B.E., Picci P., Schmidt T., Szuhai K., Hogendoorn P.C.W.
CXCL14, CXCR7 expression and CXCR4 splice variant ratio associate with survival and metastases in Ewing sarcoma patients.
Eur. J. Cancer 51:2624-2633(2015)

PubMed=30879952; DOI=10.1016/j.ymthe.2019.02.014
Kailayangiri S., Altvater B., Lesch S., Balbach S.T., Gottlich C., Kuhnemundt J., Mikesch J.-H., Schelhaas S., Jamitzky S., Meltzer J., Farwick N., Greune L., Fluegge M., Kerl K., Lode H.N., Siebert N., Muller I., Walles H., Hartmann W., Rossig C.
EZH2 inhibition in Ewing sarcoma upregulates GD2 expression for targeting with gene-modified T cells.
Mol. Ther. 27:933-946(2019)

Cross-references
Cell line databases/resources cancercelllines; CVCL_9714
Encyclopedic resources Wikidata; Q54950632
Experimental variables resources EFO; EFO_0002853
Gene expression databases GEO; GSM510007
Polymorphism and mutation databases Cosmic; 1388893
IARC_TP53; 709
Progenetix; CVCL_9714
Entry history
Entry creation06-Jun-2012
Last entry update05-Oct-2023
Version number19