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Cellosaurus VH-64 (CVCL_9672)

[Text version]
Cell line name VH-64
Synonyms VH 64; VH64
Accession CVCL_9672
Resource Identification Initiative To cite this cell line use: VH-64 (RRID:CVCL_9672)
Comments From: Van Valen F.; University of Munster; Munster; Germany.
Omics: Array-based CGH.
Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations
  • Gene deletion; HGNC; 1787; CDKN2A; Zygosity=Homozygous (PubMed=19787792).
  • Gene fusion; HGNC; 3508; EWSR1 + HGNC; 3749; FLI1; Name(s)=EWSR1-FLI1, EWS-FLI1 (PubMed=15150091).
  • Mutation; HGNC; 11998; TP53; None_reported; -; Zygosity=- (PubMed=19787792).
Disease Ewing sarcoma (NCIt: C4817)
Ewing sarcoma (ORDO: Orphanet_319)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 24Y
Category Cancer cell line
STR profile Source(s): PubMed=19787792; PubMed=30879952

Markers:
AmelogeninX
CSF1PO11,12
D2S133819,24
D3S135816,17
D5S81812,13
D7S82012
D8S117914
D13S3178,11
D16S53912
D18S5113,14
D19S43312,15
D21S1130.2,31
FGA22,23 (PubMed=30879952)
23 (PubMed=19787792)
SE3316,23
TH016
TPOX8
vWA15,19

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Publications

PubMed=1320624; DOI=10.1007/BF01225268
van Valen F., Winkelmann W., Jurgens H.
Expression of functional Y1 receptors for neuropeptide Y in human Ewing's sarcoma cell lines.
J. Cancer Res. Clin. Oncol. 118:529-536(1992)

PubMed=8335680; DOI=10.1007/BF01372725
van Valen F., Winkelmann W., Burdach S., Gobel U., Jurgens H.
Interferon gamma and tumour necrosis factor alpha induce a synergistic antiproliferative response in human Ewing's sarcoma cells in vitro.
J. Cancer Res. Clin. Oncol. 119:615-621(1993)

PubMed=8378080
Kovar H., Auinger A., Jug G., Aryee D.N.T., Zoubek A., Salzer-Kuntschik M., Gadner H.
Narrow spectrum of infrequent p53 mutations and absence of MDM2 amplification in Ewing tumours.
Oncogene 8:2683-2690(1993)

PubMed=15150091; DOI=10.1158/0008-5472.CAN-03-0809
Schaefer K.-L., Brachwitz K., Wai D.H., Braun Y., Diallo R., Korsching E., Eisenacher M., Voss R., van Valen F., Baer C., Selle B., Spahn L., Liao S.-K., Lee K.A.W., Hogendoorn P.C.W., Reifenberger G., Gabbert H.E., Poremba C.
Expression profiling of t(12;22) positive clear cell sarcoma of soft tissue cell lines reveals characteristic up-regulation of potential new marker genes including ERBB3.
Cancer Res. 64:3395-3405(2004)

PubMed=19787792; DOI=10.1002/gcc.20717
Ottaviano L., Schaefer K.-L., Gajewski M., Huckenbeck W., Baldus S.E., Rogel U., Mackintosh C., de Alava E., Myklebost O., Kresse S.H., Meza-Zepeda L.A., Serra M., Cleton-Jansen A.-M., Hogendoorn P.C.W., Buerger H., Aigner T., Gabbert H.E., Poremba C.
Molecular characterization of commonly used cell lines for bone tumor research: a trans-European EuroBoNet effort.
Genes Chromosomes Cancer 49:40-51(2010)

PubMed=21822310; DOI=10.1038/onc.2011.317
Mackintosh C., Ordonez J.L., Garcia-Dominguez D.J., Sevillano V., Llombart-Bosch A., Szuhai K., Scotlandi K., Alberghini M., Sciot R., Sinnaeve F., Hogendoorn P.C.W., Picci P., Knuutila S., Dirksen U., Debiec-Rychter M., Schaefer K.-L., de Alava E.
1q gain and CDT2 overexpression underlie an aggressive and highly proliferative form of Ewing sarcoma.
Oncogene 31:1287-1298(2012)

PubMed=26428435; DOI=10.1016/j.ejca.2015.08.020
Sand L.G.L., Scotlandi K., Berghuis D., Snaar-Jagalska B.E., Picci P., Schmidt T., Szuhai K., Hogendoorn P.C.W.
CXCL14, CXCR7 expression and CXCR4 splice variant ratio associate with survival and metastases in Ewing sarcoma patients.
Eur. J. Cancer 51:2624-2633(2015)

PubMed=30879952; DOI=10.1016/j.ymthe.2019.02.014
Kailayangiri S., Altvater B., Lesch S., Balbach S.T., Gottlich C., Kuhnemundt J., Mikesch J.-H., Schelhaas S., Jamitzky S., Meltzer J., Farwick N., Greune L., Fluegge M., Kerl K., Lode H.N., Siebert N., Muller I., Walles H., Hartmann W., Rossig C.
EZH2 inhibition in Ewing sarcoma upregulates GD2 expression for targeting with gene-modified T cells.
Mol. Ther. 27:933-946(2019)

Cross-references
Cell line databases/resources cancercelllines; CVCL_9672
Encyclopedic resources Wikidata; Q54993098
Experimental variables resources EFO; EFO_0002870
Gene expression databases GEO; GSM510015
Polymorphism and mutation databases IARC_TP53; 23653
Progenetix; CVCL_9672
Entry history
Entry creation06-Jun-2012
Last entry update05-Oct-2023
Version number22