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Cellosaurus SU-DHL-2 (CVCL_9550)

[Text version]
Cell line name SU-DHL-2
Synonyms SUDHL2; SUDHL-2; Su-DHL-2; SU-DHL2; SuDHL 2; Stanford University-Diffuse Histiocytic Lymphoma-2; DHL-2
Accession CVCL_9550
Resource Identification Initiative To cite this cell line use: SU-DHL-2 (RRID:CVCL_9550)
Comments Population: Caucasian.
Doubling time: ~24 hours (DSMZ=ACC-902).
Omics: Transcriptomics; Microarray.
Derived from site: In situ; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations
  • Mutation; HGNC; HGNC:7562; MYD88; Simple; p.Ser209Arg (c.627T>G) (p.Ser222Arg, c.666T>G) (S222R); Zygosity=Heterozygous (PubMed=21179087).
Disease Diffuse large B-cell lymphoma activated B-cell type (NCIt: C36081)
Diffuse large B-cell lymphoma (ORDO: Orphanet_544)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Age at sampling 73Y
Category Cancer cell line
STR profile Source(s): ATCC=CRL-2956; DSMZ=ACC-902

Markers:
AmelogeninX
CSF1PO12
D2S133817,24
D3S135814,19
D5S81813
D7S82011,13
D8S117913
D13S31711,12
D16S53914
D18S5111
D19S43312
D21S1130
FGA21,26
Penta D13
Penta E7,11
TH016,9
TPOX8
vWA17

Run an STR similarity search on this cell line
Publications

PubMed=4140017; DOI=10.1002/1097-0142(197412)34:6<1851::AID-CNCR2820340602>3.0.CO;2-4
Alan L. Epstein, Henry Seymour Kaplan;
Biology of the human malignant lymphomas. I. Establishment in continuous cell culture and heterotransplantation of diffuse histiocytic lymphomas.
Cancer 34:1851-1872(1974)

PubMed=214220; DOI=10.1002/1097-0142(197811)42:5<2379::AID-CNCR2820420539>3.0.CO;2-4
Alan L. Epstein, Ronald Levy, Hun Kim, Werner Henle, Gertrude Szpingier Henle, Henry Seymour Kaplan;
Biology of the human malignant lymphomas. IV. Functional characterization of ten diffuse histiocytic lymphoma cell lines.
Cancer 42:2379-2391(1978)

PubMed=83902; DOI=10.1002/1097-0142(197901)43:1<1::AID-CNCR2820430102>3.0.CO;2-M
Henry Seymour Kaplan, Robert S. Goodenow, Suzanne Gartner, Marcia M. Bieber;
Biology and virology of the human malignant lymphomas: 1st Milford D Schulz lecture.
Cancer 43:1-24(1979)

PubMed=371794
Alan L. Epstein, Henry Seymour Kaplan;
Feeder layer and nutritional requirements for the establishment and cloning of human malignant lymphoma cell lines.
Cancer Res. 39:1748-1759(1979)

PubMed=3881165; DOI=10.1016/0165-4608(85)90186-4
Barbara Kaiser-McCaw Hecht, Alan L. Epstein, Carol S. Berger, Henry Seymour Kaplan, Frederick Hecht;
Histiocytic lymphoma cell lines: immunologic and cytogenetic studies.
Cancer Genet. Cytogenet. 14:205-218(1985)

PubMed=8547074; DOI=10.1111/j.1365-2141.1995.tb05302.x
Reiner Siebert, Christoph P. Willers, Alexander Schramm, Alexander Fossa, Irina M. Gana Dresen, Michael J. Uppenkamp, Mohammad Resa Nowrousian, Siegfried Seeber, Bertram Opalka;
Homozygous loss of the MTS1/p16 and MTS2/p15 genes in lymphoma and lymphoblastic leukaemia cell lines.
Br. J. Haematol. 91:350-354(1995)

PubMed=15356658; DOI=10.1038/sj.leu.2403465
Hans Gunther Drexler, Roderick A.F. MacLeod;
Malignant hematopoietic cell lines: in vitro models for the study of anaplastic large-cell lymphoma.
Leukemia 18:1569-1571(2004)

PubMed=21179087; DOI=10.1038/nature09671; PMCID=PMC5024568
Vu N. Ngo, Ryan M. Young, Roland Schmitz, Sameer Jhavar, Wen-Ming Xiao, Kian-Huat Lim, Holger Kohlhammer, Wei-Hong Xu, Yan-Dan Yang, Hong Zhao, Arthur L. Shaffer 3rd, Paul Bernard Romesser, George Wright ...Show all 31 authors... , John I. Powell, Andreas Rosenwald, Hans-Konrad Muller-Hermelink, German Ott, Randy D. Gascoyne, Joseph M. Connors, Lisa M. Rimsza, Elias Campo, Elaine Sarkin Jaffe, Jan Delabie, Erlend Bremertun Smeland, Richard I. Fisher, Rita Merle Braziel, Raymond Roy Tubbs, James R. Cook, Dennis D. Weisenburger, Wing-Chung Chan, Louis Michael Staudt; Show fewer authors
Oncogenically active MYD88 mutations in human lymphoma.
Nature 470:115-119(2011)

Cross-references
Cell line collections (Providers) ATCC; CRL-2956
DSMZ; ACC-902
Cell line databases/resources DSMZCellDive; ACC-902
Anatomy/cell type resources BTO; BTO_0006463
Biological sample resources ENCODE; ENCBS354PZC
ENCODE; ENCBS446LEC
ENCODE; ENCBS621PAH
ENCODE; ENCBS775VGT
Chemistry resources ChEMBL-Cells; CHEMBL4523529
ChEMBL-Targets; CHEMBL4523560
PubChem_Cell_line; CVCL_9550
Encyclopedic resources Wikidata; Q54970715
Experimental variables resources EFO; EFO_0007611
Gene expression databases GEO; GSM1374905
Polymorphism and mutation databases Cosmic; 1289989
Cosmic; 1486588
Cosmic; 1517653
Cosmic; 1550339
Cosmic; 1636686
Cosmic; 2361374
Entry history
Entry creation06-Jun-2012
Last entry update10-Apr-2025
Version number28