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Cellosaurus KM12-C (CVCL_9547)

[Text version]
Cell line name KM12-C
Synonyms KM12 C; KM-12C; KM12C; KM12c; Km12C
Accession CVCL_9547
Resource Identification Initiative To cite this cell line use: KM12-C (RRID:CVCL_9547)
Comments Registration: International Depositary Authority, American Type Culture Collection (ATCC); CRL-12533.
Registration: Chiron Master Culture Collection; CMCC 11611 (CMCC #11611).
Population: Caucasian.
Microsatellite instability: Instable (MSI) (PubMed=25926053).
Omics: miRNA expression profiling.
Omics: Nuclear proteome analysis.
Omics: Transcriptome analysis by microarray.
Derived from site: In situ; Colon; UBERON=UBERON_0001155.
Sequence variations
  • Gene fusion; HGNC; 8031; NTRK1 + HGNC; 12012; TPM3; Name(s)=TPM3-NTRK1 (from parent cell line).
  • Mutation; HGNC; 173; ACVR2A; Simple; p.Lys437Argfs*5 (c.1310delA); dbSNP=rs764719749; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 583; APC; Simple; p.Asn1819fs*7 (c.5454_5455insA); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 1101; BRCA2; Simple; p.Asn1784Hisfs*7 (c.5350_5351delAA); ClinVar=VCV000037959; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 9588; PTEN; Simple; p.Gly129Ter (c.385G>T); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 9588; PTEN; Simple; p.Lys267Argfs*9 (c.800delA) (p.Leu265fs, c.795delA); ClinVar=VCV000092828; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 11773; TGFBR2; Simple; p.Lys128Serfs*35 (c.383delA); ClinVar=VCV000477546; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Val73Trpfs*50 (c.216delC) (p.P72fs); ClinVar=VCV000428897; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.His179Arg (c.536A>G); ClinVar=VCV000376606; Zygosity=Heterozygous (from parent cell line).
Disease Colon carcinoma (NCIt: C4910)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_1331 (KM12)
CVCL_4M93 (KM12-HX)CVCL_4M94 (KM12-LX)CVCL_9548 (KM12-SM)
Sex of cell Male
Age at sampling Age unspecified
Category Cancer cell line
STR profile Source(s): PubMed=25926053


Run an STR similarity search on this cell line

Morikawa K., Walker S.M., Nakajima M., Pathak S., Jessup J.M., Fidler I.J.
Influence of organ environment on the growth, selection, and metastasis of human colon carcinoma cells in nude mice.
Cancer Res. 48:6863-6871(1988)

Morikawa K., Walker S.M., Jessup J.M., Fidler I.J.
In vivo selection of highly metastatic cells from surgical specimens of different primary human colon carcinomas implanted into nude mice.
Cancer Res. 48:1943-1948(1988)

PubMed=10091941; DOI=10.1023/A:1006537609469
Nakayama Y., Okazaki K., Shibao K., Sako T., Hirata K., Nagata N., Kuwano M., Itoh H.
Alterative expression of the collagenase and adhesion molecules in the highly metastatic clones of human colonic cancer cell lines.
Clin. Exp. Metastasis 16:461-469(1998)

PubMed=15170669; DOI=10.1002/ijc.20195
Camps J., Morales C., Prat E., Ribas M., Capella G., Egozcue J., Peinado M.A., Miro R.
Genetic evolution in colon cancer KM12 cells and metastatic derivates.
Int. J. Cancer 110:869-874(2004)

PubMed=25926053; DOI=10.1038/ncomms8002
Medico E., Russo M., Picco G., Cancelliere C., Valtorta E., Corti G., Buscarino M., Isella C., Lamba S., Martinoglio B., Veronese S., Siena S., Sartore-Bianchi A., Beccuti M., Mottolese M., Linnebacher M., Cordero F., Di Nicolantonio F., Bardelli A.
The molecular landscape of colorectal cancer cell lines unveils clinically actionable kinase targets.
Nat. Commun. 6:7002.1-7002.10(2015)

PubMed=29131639; DOI=10.1021/acs.jproteome.7b00548
Torres S., Garcia-Palmero I., Marin-Vicente C., Bartolome R.A., Calvino E., Fernandez-Acenero M.J., Casal J.I.
Proteomic characterization of transcription and splicing factors associated with a metastatic phenotype in colorectal cancer.
J. Proteome Res. 17:252-264(2018)

Cell line collections (Providers) KCLB; 80015
Cell line databases/resources cancercelllines; CVCL_9547
Anatomy/cell type resources BTO; BTO:0003312
Chemistry resources ChEMBL-Cells; CHEMBL4632322
ChEMBL-Targets; CHEMBL4632329
PubChem_Cell_line; CVCL_9547
Encyclopedic resources Wikidata; Q54900054
Gene expression databases GEO; GSM1448186
GEO; GSM2299786
Polymorphism and mutation databases Cosmic; 2820474
Proteomic databases PRIDE; PXD006662
Entry history
Entry creation06-Jun-2012
Last entry update05-Oct-2023
Version number24