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Cellosaurus HeLa-APL (CVCL_9493)

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Cell line name HeLa-APL
Synonyms HeLa-R
Accession CVCL_9493
Resource Identification Initiative To cite this cell line use: HeLa-APL (RRID:CVCL_9493)
Comments Population: African American.
Characteristics: Possesses >1000-fold relative resistance to APL than the parental cell line (PubMed=15365569).
Doubling time: ~24 hours (PubMed=15365569).
Selected for resistance to: ChEBI; CHEBI_90205; Plitidepsin (Dehydrodidemnin B; Aplidin).
Transformant: NCBI_TaxID; 333761; Human papillomavirus type 18 (HPV18).
Omics: Proteomics; 2DE-MS.
Derived from site: In situ; Uterus, cervix; UBERON=UBERON_0000002.
Disease Human papillomavirus-related endocervical adenocarcinoma (NCIt: C27677)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0030 (HeLa)
Sex of cell Female
Age at sampling 30Y6M
Category Cancer cell line
Publications

PubMed=15365569; DOI=10.1038/sj.bjc.6602166; PMCID=PMC2409906
Alejandro Losada, Juan Manuel Lopez-Oliva, Jose Maria Sanchez-Puelles, Luis Fransisco Garcia-Fernandez;
Establishment and characterisation of a human carcinoma cell line with acquired resistance to aplidin.
Br. J. Cancer 91:1405-1413(2004)

PubMed=17338558; DOI=10.1021/pr060430
Laura Gonzalez-Santiago, Patricia Alfonso, Yajaira Suarez, Antonio Nunez, Luis Fransisco Garcia-Fernandez, Enrique Alvarez, Alberto Munoz, J. Ignacio Casal;
Proteomic analysis of the resistance to aplidin in human cancer cells.
J. Proteome Res. 6:1286-1294(2007)

Cross-references
Encyclopedic resources Wikidata; Q54882709
Entry history
Entry creation06-Jun-2012
Last entry update27-Nov-2025
Version number19