Cellosaurus cell line BCLC-9 (CVCL

Cellosaurus BCLC-9 (CVCL_9483)

Cross-references
Cell line name	BCLC-9
Synonyms	Barcelona Clinic Liver Cancer-9
Accession	CVCL_9483
Resource Identification Initiative	To cite this cell line use: BCLC-9 (RRID:CVCL_9483)
Comments	Characteristics: Established from a xenograft produced by implantation of tumor cells in the liver of a Swiss nude mice. Doubling time: 27.7 hours (Note=At 17th passage) (PubMed=15041736). Transformant: NCBI_TaxID; 10407; Hepatitis B virus (HBV). Derived from site: In situ; Liver; UBERON=UBERON_0002107.
Sequence variations	Mutation; HGNC; HGNC:11998; TP53; Simple; p.Gln192Arg (c.575A>G); ClinVar=VCV000182931; Zygosity=Unspecified (PubMed=15041736). Mutation; HGNC; HGNC:11998; TP53; Simple; p.Cys242Tyr (c.725G>A); ClinVar=VCV000012354; Zygosity=Unspecified (PubMed=15041736).
Disease	Adult hepatocellular carcinoma (NCIt: C7956) Adult hepatocellular carcinoma (ORDO: Orphanet_210159)
Species of origin	Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell	Female
Age at sampling	70Y
Category	Cancer cell line
Publications	PubMed=15041736; DOI=10.1158/1078-0432.CCR-03-1028 Carolina Armengol, Gemma Tarafa, Loreto Boix, Manel Sole, Rosa Queralt, Dolors Costa, Oriol Bachs, Jordi Bruix, Gabriel Capella; Orthotopic implantation of human hepatocellular carcinoma in mice: analysis of tumor progression and establishment of the BCLC-9 cell line. Clin. Cancer Res. 10:2150-2157(2004) PubMed=28751105; DOI=10.1016/j.virusres.2017.07.018 Mairene Coto-Llerena, George Koutsoudakis, Loreto Boix, Juan Manuel Lopez-Oliva, Noelia Caro-Perez, Carlos Fernandez-Carrillo, Patricia Gonzalez, Pablo Gastaminza, Jordi Bruix, Xavier Forns, Sofia Perez-del-Pulgar; Permissiveness of human hepatocellular carcinoma cell lines for hepatitis C virus entry and replication. Virus Res. 240:35-46(2017)
Cell line databases/resources	cancercelllines; CVCL_9483
Encyclopedic resources	Wikidata; Q54795691
Polymorphism and mutation databases	IARC_TP53; 20737
Entry history
Entry creation	06-Jun-2012
Last entry update	19-Dec-2024
Version number	19