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Cellosaurus YD-15 (CVCL_8930)

[Text version]

Cell line name YD-15
Synonyms YD15
Accession CVCL_8930
Resource Identification Initiative To cite this cell line use: YD-15 (RRID:CVCL_8930)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Population: Korean.
Doubling time: 19.8 hours (PubMed=16264262).
Omics: Deep exome analysis.
Omics: Deep RNAseq analysis.
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Derived from sampling site: Oral cavity; tongue.
Sequence variations
  • Mutation; HGNC; 11998; TP53; Simple; p.Glu258Ala (c.773A>C); ClinVar=VCV000458563; Zygosity=Homozygous (PubMed=16264262; DepMap).
Genome ancestry Source: PubMed=30894373

Origin% genome
African0.84
Native American1.03
East Asian, North65.12
East Asian, South31.39
South Asian0
European, North0
European, South1.62
Disease Tongue squamous cell carcinoma (NCIt: C4648)
Squamous cell carcinoma of the oral tongue (ORDO: Orphanet_457252)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Originate from same individual CVCL_L078 ! YD-15M
Sex of cell Male
Age at sampling 39Y
Category Cancer cell line
STR profile Source(s): KCLB; PubMed=16264262

Markers:
AmelogeninX,Y
CSF1PO10,12
D3S135815
D5S81812
D7S82012,13
D8S117915
D13S31711,12
D16S5399,12
D18S5114
D21S1130,31.2
FGA23
Penta D9
Penta E14,19
TH016,9
TPOX9
vWA15

Run an STR similarity search on this cell line
Publications

PubMed=16264262; DOI=10.1038/emm.2005.48
Lee E.J., Kim J., Lee S.A., Kim E.-J., Chun Y.-C., Ryu M.H., Yook J.-I.
Characterization of newly established oral cancer cell lines derived from six squamous cell carcinoma and two mucoepidermoid carcinoma cells.
Exp. Mol. Med. 37:379-390(2005)

PubMed=21496182; DOI=10.1111/j.1601-0825.2010.01774.x
Choi K.-H., Shim J.-H., Huong L.D., Cho N.-P., Cho S.-D.
Inhibition of myeloid cell leukemia-1 by tolfenamic acid induces apoptosis in mucoepidermoid carcinoma.
Oral Dis. 17:469-475(2011)

PubMed=22460905; DOI=10.1038/nature11003
Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A., Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A., Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J., Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E., Raman P., Shipway A., Engels I.H., Cheng J., Yu G.-Y.K., Yu J.-J., Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C., Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C., Liefeld T., MacConaill L.E., Winckler W., Reich M., Li N.-X., Mesirov J.P., Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L., Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M., Golub T.R., Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Nature 483:603-607(2012)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=31068700; DOI=10.1038/s41586-019-1186-3
Ghandi M., Huang F.W., Jane-Valbuena J., Kryukov G.V., Lo C.C., McDonald E.R. III, Barretina J.G., Gelfand E.T., Bielski C.M., Li H., Hu K., Andreev-Drakhlin A.Y., Kim J., Hess J.M., Haas B.J., Aguet F., Weir B.A., Rothberg M.V., Paolella B.R., Lawrence M.S., Akbani R., Lu Y., Tiv H.L., Gokhale P.C., de Weck A., Mansour A.A., Oh C., Shih J., Hadi K., Rosen Y., Bistline J., Venkatesan K., Reddy A., Sonkin D., Liu M., Lehar J., Korn J.M., Porter D.A., Jones M.D., Golji J., Caponigro G., Taylor J.E., Dunning C.M., Creech A.L., Warren A.C., McFarland J.M., Zamanighomi M., Kauffmann A., Stransky N., Imielinski M., Maruvka Y.E., Cherniack A.D., Tsherniak A., Vazquez F., Jaffe J.D., Lane A.A., Weinstock D.M., Johannessen C.M., Morrissey M.P., Stegmeier F., Schlegel R., Hahn W.C., Getz G., Mills G.B., Boehm J.S., Golub T.R., Garraway L.A., Sellers W.R.
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Nature 569:503-508(2019)

Cross-references
Cell line collections KCLB; 60504
Cell line databases/resources Cell_Model_Passport; SIDM01411
DepMap; ACH-000836
Biological sample resources BioSample; SAMN10987726
Chemistry resources PharmacoDB; YD15_1681_2019
Encyclopedic resources Wikidata; Q54995383
Gene expression databases ArrayExpress; E-MTAB-2770
GEO; GSM887744
GEO; GSM888839
Polymorphism and mutation databases IARC_TP53; 21619
LiGeA; CCLE_509
Progenetix; CVCL_8930
Entry history
Entry creation06-Jun-2012
Last entry update23-Jun-2022
Version number25