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Cellosaurus STS-26T (CVCL_8917)

[Text version]
Cell line name STS-26T
Synonyms STS-26 T; STS26T; STS26
Accession CVCL_8917
Resource Identification Initiative To cite this cell line use: STS-26T (RRID:CVCL_8917)
Comments Problematic cell line: Misclassified. Originally thought to be a malignant peripheral nerve sheath tumor (MPNST) but shown to be from a melanoma (PubMed=36818284). This is based on a number of criteria such as the result of a methylome-based classifier, immunofluorescence of cell identity markers (SOX9, SOX10, S100B) the presence of a functional PRC2 complex and of the BRAF V600E mutation. It also exhibits a much higher mutation frequency than other MPNST cell lines.
Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Characteristics: Tumorigenic (PubMed=37798904).
Doubling time: ~16 hours (PubMed=21084276), 0.80 day (PubMed=37798904).
Karyotypic information: Average ploidy of 4.05 (PubMed=36818284).
Omics: Genomics; Whole exome sequencing.
Omics: Variations; SNP array analysis.
Derived from site: Metastatic; Bone, left scapula; UBERON=UBERON_0006849.
Sequence variations
  • Gene deletion; HGNC; HGNC:11998; TP53; Zygosity=Homozygous (PubMed=21084276).
  • Mutation; HGNC; HGNC:1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Heterozygous (PubMed=36818284).
  • Mutation; HGNC; HGNC:1787; CDKN2A; Simple; p.Pro114Leu (c.341_342delinsTT) (p.Arg129Cys, c.384_385delinsTT); Zygosity=Heterozygous (PubMed=34059954).
Disease Melanoma (NCIt: C3224)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Age at sampling 51Y
Category Cancer cell line
STR profile Source(s): PubMed=28556483; PubMed=32076030; PubMed=33707600; PubMed=36818284

Markers:
AmelogeninX
CSF1PO10,13
D2S133820
D3S135814 (PubMed=28556483; PubMed=32076030; PubMed=36818284)
14,20 (PubMed=33707600)
D5S81811,12
D7S8208,11
D8S117913,14
D13S3179,10
D16S53912,13
D18S5117,18
D19S43314
D21S1130,31 (PubMed=28556483; PubMed=32076030; PubMed=36818284)
31 (PubMed=33707600)
FGA22,23
Penta D8,12
Penta E12,13
TH016,9.3
TPOX8
vWA17

Run an STR similarity search on this cell line
Publications

PubMed=8094415; DOI=10.1080/09553009314550251
Dahlberg W.K., Little J.B., Fletcher J.A., Suit H.D., Okunieff P.
Radiosensitivity in vitro of human soft tissue sarcoma cell lines and skin fibroblasts derived from the same patients.
Int. J. Radiat. Biol. 63:191-198(1993)

PubMed=9766530; DOI=10.1002/(SICI)1097-4652(199811)177:2<334::AID-JCP15>3.0.CO;2-9
Badache A., de Vries G.H.
Neurofibrosarcoma-derived Schwann cells overexpress platelet-derived growth factor (PDGF) receptors and are induced to proliferate by PDGF BB.
J. Cell. Physiol. 177:334-342(1998)

PubMed=16239399; DOI=10.1124/jpet.105.091454
Mattingly R.R., Kraniak J.M., Dilworth J.T., Mathieu P., Bealmear B., Nowak J.E., Benjamins J.A., Tainsky M.A., Reiners J.J. Jr.
The mitogen-activated protein kinase/extracellular signal-regulated kinase kinase inhibitor PD184352 (CI-1040) selectively induces apoptosis in malignant schwannoma cell lines.
J. Pharmacol. Exp. Ther. 316:456-465(2006)

PubMed=16510576; DOI=10.1158/0008-5472.CAN-05-3330
Miller S.J., Rangwala F., Williams J., Ackerman P., Kong S., Jegga A.G., Kaiser S., Aronow B.J., Frahm S., Kluwe L., Mautner V.-F., Upadhyaya M., Muir D.F. 4th, Wallace M.R., Hagen J., Quelle D.E., Watson M.A., Perry A., Gutmann D.H., Ratner N.
Large-scale molecular comparison of human Schwann cells to malignant peripheral nerve sheath tumor cell lines and tissues.
Cancer Res. 66:2584-2591(2006)

PubMed=21084276; DOI=10.1158/0008-5472.CAN-10-2799; PMCID=PMC3064267
Lopez G., Torres K.E., Liu J.J.-H., Hernandez B., Young E.D., Belousov R., Bolshakov S.V., Lazar A.J.F., Slopis J.M., McCutcheon I.E., McConkey D.J., Lev D.C.
Autophagic survival in resistance to histone deacetylase inhibitors: novel strategies to treat malignant peripheral nerve sheath tumors.
Cancer Res. 71:185-196(2011)

PubMed=22346343; DOI=10.4137/TOG.S8830; PMCID=PMC3273949
Sun D., Tainsky M.A., Haddad R.
Oncogene mutation survey in MPNST cell lines enhances the dominant role of hyperactive Ras in NF1 associated pro-survival and malignancy.
Transl. Oncogenomics 5:1-7(2012)

PubMed=23437333; DOI=10.1371/journal.pone.0057152; PMCID=PMC3578816
Reuss D.E., Mucha J., Hagenlocher C., Ehemann V., Kluwe L., Mautner V.-F., von Deimling A.
Sensitivity of malignant peripheral nerve sheath tumor cells to TRAIL is augmented by loss of NF1 through modulation of MYC/MAD and is potentiated by curcumin through induction of ROS.
PLoS ONE 8:e57152.1-e57152.10(2013)

PubMed=24726063; DOI=10.1186/1756-9966-33-33; PMCID=PMC4022359
Koelsche C., Renner M., Hartmann W., Brandt R., Lehner B., Waldburger N., Alldinger I., Schmitt T., Egerer G., Penzel R., Wardelmann E., Schirmacher P., von Deimling A., Mechtersheimer G.
TERT promoter hotspot mutations are recurrent in myxoid liposarcomas but rare in other soft tissue sarcoma entities.
J. Exp. Clin. Cancer Res. 33:33.1-33.8(2014)

PubMed=28469964; PMCID=PMC5411799
Guo J.-M., Grovola M.R., Xie H., Coggins G.E., Duggan P., Hasan R., Huang J.-L., Lin D.W., Song C., Witek G.M., Berritt S., Schultz D.C., Field J.
Comprehensive pharmacological profiling of neurofibromatosis cell lines.
Am. J. Cancer Res. 7:923-934(2017)

PubMed=28556483; DOI=10.1002/1878-0261.12086; PMCID=PMC5579334
Kolberg M., Bruun J., Murumagi A., Mpindi J.P., Bergsland C.H., Holand M., Eilertsen I.A., Danielsen S.A., Kallioniemi O.-P., Lothe R.A.
Drug sensitivity and resistance testing identifies PLK1 inhibitors and gemcitabine as potent drugs for malignant peripheral nerve sheath tumors.
Mol. Oncol. 11:1156-1171(2017)

PubMed=32076030; DOI=10.1038/s41598-020-59789-4; PMCID=PMC7031337
Amirnasr A., Verdijk R.M., van Kuijk P.F., Kartal P., Vriends A.L.M., French P.J., van Royen M.E., Taal W., Sleijfer S., Wiemer E.A.C.
Deregulated microRNAs in neurofibromatosis type 1 derived malignant peripheral nerve sheath tumors.
Sci. Rep. 10:2927.1-2927.14(2020)

PubMed=32642732; DOI=10.1093/noajnl/vdz049; PMCID=PMC7317054
Pemov A., Li H., Presley W., Wallace M.R., Miller D.T.
Genetics of human malignant peripheral nerve sheath tumors.
Neurooncol. Adv. 2:i50-i61(2020)

PubMed=33707600; DOI=10.1038/s41598-021-85055-2; PMCID=PMC7952412
Longo J.F., Brosius S.N., Znoyko I., Alers V.A., Jenkins D.P., Wilson R.C., Carroll A.J. 3rd, Wolff D.J., Roth K.A., Carroll S.L.
Establishment and genomic characterization of a sporadic malignant peripheral nerve sheath tumor cell line.
Sci. Rep. 11:5690.1-5690.19(2021)

PubMed=34059954; DOI=10.1007/s00439-021-02296-x
Magallon-Lorenz M., Fernandez-Rodriguez J., Terribas E., Creus-Bachiller E., Romagosa C., Estival A., Perez Sidelnikova D., Salvador H., Villanueva A., Blanco I., Carrio M., Lazaro C., Serra E., Gel B.
Chromosomal translocations inactivating CDKN2A support a single path for malignant peripheral nerve sheath tumor initiation.
Hum. Genet. 140:1241-1252(2021)

PubMed=36818284; DOI=10.1016/j.isci.2023.106096; PMCID=PMC9929861
Magallon-Lorenz M., Terribas E., Ortega-Bertran S., Creus-Bachiller E., Fernandez M., Requena G., Rosas I., Mazuelas H., Uriarte-Arrazola I., Negro A., Lausova T., Castellanos E., Blanco I., DeVries G.H., Kawashima H., Legius E., Brems H., Mautner V.-F., Kluwe L., Ratner N., Wallace M.R., Fernandez-Rodriguez J., Lazaro C., Fletcher J.A., Reuss D.E., Carrio M., Gel B., Serra E.
Deep genomic analysis of malignant peripheral nerve sheath tumor cell lines challenges current malignant peripheral nerve sheath tumor diagnosis.
iScience 26:106096.1-106096.22(2023)

PubMed=37798904; DOI=10.1002/1878-0261.13534; PMCID=PMC10994238
Creus-Bachiller E., Fernandez-Rodriguez J., Magallon-Lorenz M., Ortega-Bertran S., Navas-Rutete S., Romagosa C., Silva T.M., Pane Foix M., Estival A., Perez Sidelnikova D., Morell Ginesta M., Mazuelas H., Carrio M., Lausova T., Reuss D.E., Gel B., Villanueva A., Serra E., Lazaro C.
Expanding a precision medicine platform for malignant peripheral nerve sheath tumors: new patient-derived orthotopic xenografts, cell lines and tumor entities.
Mol. Oncol. 18:895-917(2024)

Cross-references
Cell line databases/resources DepMap; ACH-002695
Anatomy/cell type resources BTO; BTO_0003226
Encyclopedic resources Wikidata; Q54970640
Experimental variables resources EFO; EFO_0006296
Polymorphism and mutation databases Cosmic; 1644551
Cosmic; 1801813
Cosmic; 2307728
Entry history
Entry creation06-Jun-2012
Last entry update10-Apr-2025
Version number26