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Cellosaurus STS-26T (CVCL_8917)

[Text version]
Cell line name STS-26T
Synonyms STS-26 T; STS26T; STS26
Accession CVCL_8917
Resource Identification Initiative To cite this cell line use: STS-26T (RRID:CVCL_8917)
Comments Problematic cell line: Misclassified. Originally thought to be a malignant peripheral nerve sheath tumor (MPNST) but shown to be from a melanoma (PubMed=36818284). This is based on a number of criteria such as the result of a methylome-based classifier, immunofluorescence of cell identity markers (SOX9, SOX10, S100B) the presence of a functional PRC2 complex and of the BRAF V600E mutation. It also exhibits a much higher mutation frequency than other MPNST cell lines.
Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Characteristics: Tumorigenic (PubMed=37798904).
Doubling time: ~16 hours (PubMed=21084276), 0.80 day (PubMed=37798904).
Karyotypic information: Average ploidy of 4.05 (PubMed=36818284).
Omics: Genomics; Whole exome sequencing.
Omics: Variations; SNP array analysis.
Derived from site: Metastatic; Bone, left scapula; UBERON=UBERON_0006849.
Sequence variations
  • Gene deletion; HGNC; HGNC:11998; TP53; Zygosity=Homozygous (PubMed=21084276).
  • Mutation; HGNC; HGNC:1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Heterozygous (PubMed=36818284).
  • Mutation; HGNC; HGNC:1787; CDKN2A; Simple; p.Pro114Leu (c.341_342delinsTT) (p.Arg129Cys, c.384_385delinsTT); Zygosity=Heterozygous (PubMed=34059954).
Disease Melanoma (NCIt: C3224)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Age at sampling 51Y
Category Cancer cell line
STR profile Source(s): PubMed=28556483; PubMed=32076030; PubMed=33707600; PubMed=36818284

Markers:
AmelogeninX
CSF1PO10,13
D2S133820
D3S135814 (PubMed=28556483; PubMed=32076030; PubMed=36818284)
14,20 (PubMed=33707600)
D5S81811,12
D7S8208,11
D8S117913,14
D13S3179,10
D16S53912,13
D18S5117,18
D19S43314
D21S1130,31 (PubMed=28556483; PubMed=32076030; PubMed=36818284)
31 (PubMed=33707600)
FGA22,23
Penta D8,12
Penta E12,13
TH016,9.3
TPOX8
vWA17

Run an STR similarity search on this cell line
Publications

PubMed=8094415; DOI=10.1080/09553009314550251
William K. Dahlberg, John Bertram Little, Jonathan A. Fletcher, Herman Day Suit, Paul Okunieff;
Radiosensitivity in vitro of human soft tissue sarcoma cell lines and skin fibroblasts derived from the same patients.
Int. J. Radiat. Biol. 63:191-198(1993)

PubMed=9766530; DOI=10.1002/(SICI)1097-4652(199811)177:2<334::AID-JCP15>3.0.CO;2-9
Ali Badache, George H. de Vries;
Neurofibrosarcoma-derived Schwann cells overexpress platelet-derived growth factor (PDGF) receptors and are induced to proliferate by PDGF BB.
J. Cell. Physiol. 177:334-342(1998)

PubMed=16239399; DOI=10.1124/jpet.105.091454
Raymond Richard Mattingly, Janice M. Kraniak, Joshua T. Dilworth, Patricia Mathieu, Beverly Bealmear, James E. Nowak, Joyce A. Benjamins, Michael A. Tainsky, John J. Reiners Jr.;
The mitogen-activated protein kinase/extracellular signal-regulated kinase kinase inhibitor PD184352 (CI-1040) selectively induces apoptosis in malignant schwannoma cell lines.
J. Pharmacol. Exp. Ther. 316:456-465(2006)

PubMed=16510576; DOI=10.1158/0008-5472.CAN-05-3330
Shyra J. Miller, Fatima Rangwala, Jon Williams, Peter Ackerman, Sue Kong, Anil G. Jegga, Sergio Kaiser, Bruce J. Aronow, Silke Frahm, Lan Kluwe, Victor-Felix Mautner ...Show all 20 authors... , Meena Upadhyaya, David F. Muir 4th, Margaret R. Wallace, Jussara Hagen, Dawn E. Quelle, Mark A. Watson, Arie Perry, David Hillel Gutmann, Nancy Ratner; Show fewer authors
Large-scale molecular comparison of human Schwann cells to malignant peripheral nerve sheath tumor cell lines and tissues.
Cancer Res. 66:2584-2591(2006)

PubMed=21084276; DOI=10.1158/0008-5472.CAN-10-2799; PMCID=PMC3064267
Gonzalo Lopez, Keila Enitt Torres, Jeffrey Jue-Hui Liu, Belinda Hernandez, Eric D. Young, Roman Belousov, Svetlana V. Bolshakov, Alexander J.F. Lazar, John M. Slopis, Ian E. McCutcheon, David J. McConkey, Dina Chelouche Lev;
Autophagic survival in resistance to histone deacetylase inhibitors: novel strategies to treat malignant peripheral nerve sheath tumors.
Cancer Res. 71:185-196(2011)

PubMed=22346343; DOI=10.4137/TOG.S8830; PMCID=PMC3273949
Dao-Chun Sun, Michael A. Tainsky, Ramsi Haddad;
Oncogene mutation survey in MPNST cell lines enhances the dominant role of hyperactive Ras in NF1 associated pro-survival and malignancy.
Transl. Oncogenomics 5:1-7(2012)

PubMed=23437333; DOI=10.1371/journal.pone.0057152; PMCID=PMC3578816
David E. Reuss, Jana Mucha, Christian Hagenlocher, Volker Ehemann, Lan Kluwe, Victor-Felix Mautner, Andreas von Deimling;
Sensitivity of malignant peripheral nerve sheath tumor cells to TRAIL is augmented by loss of NF1 through modulation of MYC/MAD and is potentiated by curcumin through induction of ROS.
PLoS ONE 8:e57152.1-e57152.10(2013)

PubMed=24726063; DOI=10.1186/1756-9966-33-33; PMCID=PMC4022359
Christian Koelsche, Marcus Renner, Wolfgang Hartmann, Regine Brandt, Burkhard Lehner, Nina Waldburger, Ingo Alldinger, Thomas Schmitt, Gerlinde Egerer, Roland Penzel, Eva Wardelmann ...Show all 14 authors... , Peter Schirmacher, Andreas von Deimling, Gunhild Mechtersheimer; Show fewer authors
TERT promoter hotspot mutations are recurrent in myxoid liposarcomas but rare in other soft tissue sarcoma entities.
J. Exp. Clin. Cancer Res. 33:33.1-33.8(2014)

PubMed=28469964; PMCID=PMC5411799
Jian-Man Guo, Michael R. Grovola, Hong Xie, Grace E. Coggins, Patrick Duggan, Rukhsana Hasan, Jia-Le Huang, Danny W. Lin, Claire Song, Gabriela M. Witek, Simon Berritt ...Show all 13 authors... , David C. Schultz, Jeffrey Field; Show fewer authors
Comprehensive pharmacological profiling of neurofibromatosis cell lines.
Am. J. Cancer Res. 7:923-934(2017)

PubMed=28556483; DOI=10.1002/1878-0261.12086; PMCID=PMC5579334
Matthias Kolberg, Jarle Bruun, Astrid Murumagi, John Patrick Mpindi, Christian H. Bergsland, Maren Holand, Ina A. Eilertsen, Stine A. Danielsen, Olli-Pekka Kallioniemi, Ragnhild Adelheid Lothe;
Drug sensitivity and resistance testing identifies PLK1 inhibitors and gemcitabine as potent drugs for malignant peripheral nerve sheath tumors.
Mol. Oncol. 11:1156-1171(2017)

PubMed=32076030; DOI=10.1038/s41598-020-59789-4; PMCID=PMC7031337
Azadeh Amirnasr, Robert M. Verdijk, Patricia F. van Kuijk, Pinar Kartal, Anne L.M. Vriends, Pim J. French, Martin Eduard van Royen, Walter Taal, Stefan Sleijfer, Erik A.C. Wiemer;
Deregulated microRNAs in neurofibromatosis type 1 derived malignant peripheral nerve sheath tumors.
Sci. Rep. 10:2927.1-2927.14(2020)

PubMed=32642732; DOI=10.1093/noajnl/vdz049; PMCID=PMC7317054
Alexander Pemov, Hua Li, William Presley, Margaret R. Wallace, David T. Miller;
Genetics of human malignant peripheral nerve sheath tumors.
Neurooncol. Adv. 2:i50-i61(2020)

PubMed=33707600; DOI=10.1038/s41598-021-85055-2; PMCID=PMC7952412
Jody Fromm Longo, Stephanie N. Brosius, Iya Znoyko, Victoria A. Alers, Dorea Pleasant Jenkins, Robert C. Wilson, Andrew J. Carroll 3rd, Daynna J. Wolff, Kevin A. Roth, Steven Lewis Carroll;
Establishment and genomic characterization of a sporadic malignant peripheral nerve sheath tumor cell line.
Sci. Rep. 11:5690.1-5690.19(2021)

PubMed=34059954; DOI=10.1007/s00439-021-02296-x
Miriam Magallon-Lorenz, Juana Fernandez-Rodriguez, Ernest Terribas, Edgar Creus-Bachiller, Cleofe Romagosa, Anna Estival, Diana Perez Sidelnikova, Hector Salvador, Alberto Villanueva, Ignacio Blanco, Meritxell Carrio ...Show all 14 authors... , Conxi Lazaro, Eduard Serra, Bernat Gel; Show fewer authors
Chromosomal translocations inactivating CDKN2A support a single path for malignant peripheral nerve sheath tumor initiation.
Hum. Genet. 140:1241-1252(2021)

PubMed=36818284; DOI=10.1016/j.isci.2023.106096; PMCID=PMC9929861
Miriam Magallon-Lorenz, Ernest Terribas, Sara Ortega-Bertran, Edgar Creus-Bachiller, Marco Fernandez, Gerard Requena, Inma Rosas, Helena Mazuelas, Itziar Uriarte-Arrazola, Alex Negro, Tereza Lausova ...Show all 28 authors... , Elisabeth Castellanos, Ignacio Blanco, George Henry DeVries, Hiroyuki Kawashima, Eric Legius, Hilde Brems, Victor-Felix Mautner, Lan Kluwe, Nancy Ratner, Margaret R. Wallace, Juana Fernandez-Rodriguez, Conxi Lazaro, Jonathan A. Fletcher, David E. Reuss, Meritxell Carrio, Bernat Gel, Eduard Serra; Show fewer authors
Deep genomic analysis of malignant peripheral nerve sheath tumor cell lines challenges current malignant peripheral nerve sheath tumor diagnosis.
iScience 26:106096.1-106096.22(2023)

PubMed=37798904; DOI=10.1002/1878-0261.13534; PMCID=PMC10994238
Edgar Creus-Bachiller, Juana Fernandez-Rodriguez, Miriam Magallon-Lorenz, Sara Ortega-Bertran, Susana Navas-Rutete, Cleofe Romagosa, Tulio M. Silva, Maria Pane Foix, Anna Estival, Diana Perez Sidelnikova, Mireia Morell Ginesta ...Show all 19 authors... , Helena Mazuelas, Meritxell Carrio, Tereza Lausova, David E. Reuss, Bernat Gel, Alberto Villanueva, Eduard Serra, Conxi Lazaro; Show fewer authors
Expanding a precision medicine platform for malignant peripheral nerve sheath tumors: new patient-derived orthotopic xenografts, cell lines and tumor entities.
Mol. Oncol. 18:895-917(2024)

Cross-references
Cell line databases/resources DepMap; ACH-002695
Anatomy/cell type resources BTO; BTO_0003226
Encyclopedic resources Wikidata; Q54970640
Experimental variables resources EFO; EFO_0006296
Polymorphism and mutation databases Cosmic; 1644551
Cosmic; 1801813
Cosmic; 2307728
Entry history
Entry creation06-Jun-2012
Last entry update10-Apr-2025
Version number26