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Cellosaurus KRJ-I (CVCL_8886)

[Text version]
Cell line name KRJ-I
Synonyms KRJ-1; KRJI; KRJ1
Accession CVCL_8886
Resource Identification Initiative To cite this cell line use: KRJ-I (RRID:CVCL_8886)
Comments Problematic cell line: Misclassified. Originally thought to arise from a multifocal carcinoid of the small intestine but shown to be an EBV-transformed lymphoblastoid cell line (PubMed=29444910; PubMed=31548718). Although misidentified, it has been argued that transcriptional regulation of the cells enough resemble gastroenteropancreatic neuroendocrine tumors to be used in studies (PubMed=31548719).
Population: Caucasian.
Doubling time: 1.8 days (PubMed=21544390).
Transformant: NCBI_TaxID; 10376; Epstein-Barr virus (EBV).
Omics: Transcriptomics; Microarray.
Derived from site: In situ; Small intestine, ileum; UBERON=UBERON_0002116.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Originate from same individual CVCL_L295 ! KRJ-II
Sex of cell Male
Age at sampling 75Y
Category Transformed cell line
STR profile Source(s): PubMed=29444910

Markers:
AmelogeninX,Y
CSF1PO11,13
D5S81811
D7S82010
D13S31711,12
D16S53911,12
D21S1128,29
TH017,9
TPOX10
vWA18,19

Run an STR similarity search on this cell line
Publications

PubMed=21544390; DOI=10.3892/ijo.8.3.513
Roswitha Pfragner, Gerhard Hubert Wirnsberger, Bruno Niederle, Annemarie Behmel, Ingo Rinner, Andreas Mandl, Friedrun Wawrina, Jian-Song Luo, Dieter Adamiker, Harald Hoger, Elisabeth Ingolic, Konrad Schauenstein;
Establishment of a continuous cell line from a human carcinoid of the small intestine (KRJ-I).
Int. J. Oncol. 8:513-520(1996)

PubMed=17242179; DOI=10.1677/jme.1.02037
Mark Kidd, Geeta N. Eick, Irvin M. Modlin, Roswitha Pfragner, Manish C. Champaneria, John Robert Murren;
Further delineation of the continuous human neoplastic enterochromaffin cell line, KRJ-I, and the inhibitory effects of lanreotide and rapamycin.
J. Mol. Endocrinol. 38:181-192(2007)

PubMed=19295186; DOI=10.1159/000209330
Zakiya-Luna Siddique, Ignat Drozdov, Jared Floch, Bjorn Inge Gustafsson, Kamilla Stunes, Roswitha Pfragner, Mark Kidd, Irvin M. Modlin;
KRJ-I and BON cell lines: defining an appropriate enterochromaffin cell neuroendocrine tumor model.
Neuroendocrinology 89:458-470(2009)

PubMed=22538498; DOI=10.1159/000338793
Simona Grozinsky-Glasberg, Ilan Shimon, Hadara Rubinfeld;
The role of cell lines in the study of neuroendocrine tumors.
Neuroendocrinology 96:173-187(2012)

PubMed=23119007; DOI=10.1371/journal.pone.0048411; PMCID=PMC3485222
Su-Chen Li, Cecile Martijn, Tao Cui, Ahmed Essaghir, Raul M. Luque, Jean-Baptiste Demoulin, Justo P. Castano, Kjell E. Oberg, Valeria Giandomenico;
The somatostatin analogue octreotide inhibits growth of small intestine neuroendocrine tumour cells.
PLoS ONE 7:e48411.1-e48411.12(2012)

PubMed=29444910; DOI=10.1530/ERC-17-0445; PMCID=PMC5827037
Tobias Hofving, Yvonne Arvidsson, Bilal Almobarak, Linda Inge, Roswitha Pfragner, Marta Persson, Goran Stenman, Erik Kristiansson, Viktor Johanson, Ola Nilsson;
The neuroendocrine phenotype, genomic profile and therapeutic sensitivity of GEPNET cell lines.
Endocr. Relat. Cancer 25:367-380(2018)

PubMed=31548718; DOI=10.1038/s41588-019-0490-z
Tobias Hofving, Joakim W. Karlsson, Ola Nilsson, Jonas A. Nilsson;
H-STS, L-STS and KRJ-I are not authentic GEPNET cell lines.
Nat. Genet. 51:1426-1427(2019)

PubMed=31548719; DOI=10.1038/s41588-019-0509-5; PMCID=PMC7256901
Mariano J. Alvarez, Peng-Rong Yan, Mary L. Alpaugh, Michaela Bowden, Ewa T. Sicinska, Chen-Sheng W. Zhou, Charles Karan, Ronald B. Realubit, Prabhjot Singh Mundi, Adina Grunn, Dirk Jager ...Show all 21 authors... , John A. Chabot, Antonio Fojo, Paul E. Oberstein, Hanina Hibshoosh, Jeffrey W. Milsom, Matthew Helmut Kulke, Massimo Loda, Gabriela Chiosis, Diane L. Reidy-Lagunes, Andrea Califano; Show fewer authors
Reply to 'H-STS, L-STS and KRJ-I are not authentic GEPNET cell lines'.
Nat. Genet. 51:1427-1428(2019)

Cross-references
Cell line collections (Providers) ECACC; 95041223 - Discontinued
Cell line databases/resources CLO; CLO_0007120
Encyclopedic resources Wikidata; Q54900482
Gene expression databases GEO; GSM600370
GEO; GSM830111
Entry history
Entry creation06-Jun-2012
Last entry update14-Aug-2025
Version number18