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Cellosaurus EU-6 (CVCL_8864)

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Cell line name EU-6
Synonyms 920; Line 920; Emory University-6
Accession CVCL_8864
Resource Identification Initiative To cite this cell line use: EU-6 (RRID:CVCL_8864)
Comments Derived from site: In situ; Bone marrow; UBERON=UBERON_0002371.
Sequence variations
Disease Childhood B acute lymphoblastic leukemia (NCIt: C9140)
Precursor B-cell acute lymphoblastic leukemia (ORDO: Orphanet_99860)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Age at sampling 9Y
Category Cancer cell line
STR profile Source(s): COG

Markers:
AmelogeninX
CSF1PO10,11
D2S133817,24,25
D3S135817
D5S81811,12
D7S8209
D8S117912,13
D13S3178,14
D16S5399,12
D18S5112,13,16
D19S43312,14
D21S1127,29
FGA22,24
TH018,9.3
TPOX8
vWA17,18

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Web pages Provider; Emory OTT; 12178; https://emoryott.technologypublisher.com/techcase/12178
Publications

PubMed=7630190
Mu-Xiang Zhou, Lu-Bing Gu, Charles David James, Ju He, Andrew M. Yeager, Stephen D. Smith, Harry W. Findley Jr.;
Homozygous deletions of the CDKN2 (MTS1/p16ink4) gene in cell lines established from children with acute lymphoblastic leukemia.
Leukemia 9:1159-1161(1995)

PubMed=7888679; DOI=10.1182/blood.V85.6.1608.bloodjournal8561608
Mu-Xiang Zhou, Andrew M. Yeager, Stephen D. Smith, Harry W. Findley Jr.;
Overexpression of the MDM2 gene by childhood acute lymphoblastic leukemia cells expressing the wild-type p53 gene.
Blood 85:1608-1614(1995)

PubMed=9108419; DOI=10.1182/blood.V89.8.2986
Harry W. Findley Jr., Lu-Bing Gu, Andrew M. Yeager, Mu-Xiang Zhou;
Expression and regulation of Bcl-2, Bcl-xl, and Bax correlate with p53 status and sensitivity to apoptosis in childhood acute lymphoblastic leukemia.
Blood 89:2986-2993(1997)

PubMed=9823951; DOI=10.1038/sj.leu.2401198
Mu-Xiang Zhou, Lu-Bing Gu, Andrew M. Yeager, Harry W. Findley Jr.;
Sensitivity to Fas-mediated apoptosis in pediatric acute lymphoblastic leukemia is associated with a mutant p53 phenotype and absence of Bcl-2 expression.
Leukemia 12:1756-1763(1998)

Cross-references
Cell line databases/resources cancercelllines; CVCL_8864
Encyclopedic resources Wikidata; Q54832866
Polymorphism and mutation databases IARC_TP53; 3826
Entry history
Entry creation06-Jun-2012
Last entry update10-Apr-2025
Version number19