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Cellosaurus EU-4 (CVCL_8862)

[Text version]
Cell line name EU-4
Synonyms 870; Line 870 Emory University-4
Accession CVCL_8862
Resource Identification Initiative To cite this cell line use: EU-4 (RRID:CVCL_8862)
Comments Derived from site: In situ; Bone marrow; UBERON=UBERON_0002371.
Disease Childhood B acute lymphoblastic leukemia (NCIt: C9140)
Precursor B-cell acute lymphoblastic leukemia (ORDO: Orphanet_99860)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Sex unspecified
Age at sampling Children
Category Cancer cell line
Web pages Provider; Emory OTT; 12177; https://emoryott.technologypublisher.com/techcase/12177
Publications

PubMed=7630190
Zhou M.-X., Gu L.-B., James C.D., He J., Yeager A.M., Smith S.D., Findley H.W. Jr.
Homozygous deletions of the CDKN2 (MTS1/p16ink4) gene in cell lines established from children with acute lymphoblastic leukemia.
Leukemia 9:1159-1161(1995)

PubMed=7888679; DOI=10.1182/blood.V85.6.1608.bloodjournal8561608
Zhou M.-X., Yeager A.M., Smith S.D., Findley H.W. Jr.
Overexpression of the MDM2 gene by childhood acute lymphoblastic leukemia cells expressing the wild-type p53 gene.
Blood 85:1608-1614(1995)

PubMed=9108419; DOI=10.1182/blood.V89.8.2986
Findley H.W. Jr., Gu L.-B., Yeager A.M., Zhou M.-X.
Expression and regulation of Bcl-2, Bcl-xl, and Bax correlate with p53 status and sensitivity to apoptosis in childhood acute lymphoblastic leukemia.
Blood 89:2986-2993(1997)

PubMed=9823951; DOI=10.1038/sj.leu.2401198
Zhou M.-X., Gu L.-B., Yeager A.M., Findley H.W. Jr.
Sensitivity to Fas-mediated apoptosis in pediatric acute lymphoblastic leukemia is associated with a mutant p53 phenotype and absence of Bcl-2 expression.
Leukemia 12:1756-1763(1998)

Cross-references
Encyclopedic resources Wikidata; Q54832864
Entry history
Entry creation06-Jun-2012
Last entry update10-Apr-2025
Version number14