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Cellosaurus HS-SY-2 (CVCL_8719)

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Cell line name HS-SY-2
Synonyms HS-SY-II; HSSY-II; HSSYII; HSSY2; Hiroshi Sonobe-SYnovial-2
Accession CVCL_8719
Resource Identification Initiative To cite this cell line use: HS-SY-2 (RRID:CVCL_8719)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Population: Japanese.
Doubling time: ~60 hours (PubMed=1331610).
Omics: Transcriptomics; RNAseq.
Misspelling: HS-SY-11; Note=Occasionally.
Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations
Disease Monophasic synovial sarcoma (NCIt: C6534)
Synovial sarcoma (ORDO: Orphanet_3273)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling Adult
Category Cancer cell line
STR profile Source(s): RCB=RCB2231

Markers:
AmelogeninX,Y
CSF1PO11,12
D5S81810,12
D7S82010,12
D13S31710
D16S5399
TH018
TPOX8,12
vWA17,18

Run an STR similarity search on this cell line
Publications

PubMed=1331610
Hiroshi Sonobe, Yuiko Manabe, Mutsuo Furihata, Jun Iwata, Takashi Oka, Yuji Ohtsuki, Hiroo Mizobuchi, Hiroshi Yamamoto, Osamu Kumano, Syuiti Abe;
Establishment and characterization of a new human synovial sarcoma cell line, HS-SY-II.
Lab. Invest. 67:498-505(1992)

PubMed=7539744; DOI=10.1002/j.1460-2075.1995.tb07228.x; PMCID=PMC398342
A. Jayne Crew, Jeremy Clark, Cyril Fisher, Sandra Gill, Robert Grimer, Aarti Chand, Janet M. Shipley, Barry Austin Gusterson, Colin S. Cooper;
Fusion of SYT to two genes, SSX1 and SSX2, encoding proteins with homology to the Kruppel-associated box in human synovial sarcoma.
EMBO J. 14:2333-2340(1995)

PubMed=7736791; DOI=10.1159/000133992
Pamela J. Renwick, Brian R. Reeves, Paola S. Dal Cin, Christopher David Marsden Fletcher, Helena Maria Kempski, Raf Sciot, Bernd Kazmierczak, Kandarp Jani, Hiroshi Sonobe, Jennifer C. Knight;
Two categories of synovial sarcoma defined by divergent chromosome translocation breakpoints in Xp11.2, with implications for the histologic sub-classification of synovial sarcoma.
Cytogenet. Cell Genet. 70:58-63(1995)

PubMed=24726063; DOI=10.1186/1756-9966-33-33; PMCID=PMC4022359
Christian Koelsche, Marcus Renner, Wolfgang Hartmann, Regine Brandt, Burkhard Lehner, Nina Waldburger, Ingo Alldinger, Thomas Schmitt, Gerlinde Egerer, Roland Penzel, Eva Wardelmann ...Show all 14 authors... , Peter Schirmacher, Andreas von Deimling, Gunhild Mechtersheimer; Show fewer authors
TERT promoter hotspot mutations are recurrent in myxoid liposarcomas but rare in other soft tissue sarcoma entities.
J. Exp. Clin. Cancer Res. 33:33.1-33.8(2014)

PubMed=26351324; DOI=10.1158/1535-7163.MCT-15-0074; PMCID=PMC4636476
Beverly A. Teicher, Eric C. Polley, Mark W. Kunkel, David Evans, Thomas E. Silvers, Rene M. Delosh, Julie Laudeman, Chad Ogle, Russell Reinhart, Michael Selby, John Connelly ...Show all 14 authors... , Erik Harris, Anne Monks, Joel Morris; Show fewer authors
Sarcoma cell line screen of oncology drugs and investigational agents identifies patterns associated with gene and microRNA expression.
Mol. Cancer Ther. 14:2452-2462(2015)

Cross-references
Cell line collections (Providers) RCB; RCB2231
Cell line databases/resources CLO; CLO_0050072
cancercelllines; CVCL_8719
DepMap; ACH-002085
Anatomy/cell type resources BTO; BTO_0006086
Biological sample resources BioSample; SAMN03472029
Encyclopedic resources Wikidata; Q54896293
Gene expression databases FANTOM5_SSTAR; 10441-106E9
GEO; GSM482569
GEO; GSM1676333
GEO; GSM1701665
GEO; GSM2887618
GEO; GSM2887619
Polymorphism and mutation databases Cosmic; 1217465
Cosmic; 1319811
Cosmic; 2307724
Progenetix; CVCL_8719
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number28