Cellosaurus HS-Sch-2 (CVCL_8718)
Cell line name | HS-Sch-2 | ||||||||||||||||||||||||||||||||
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Synonyms | HS-sch-2; HSSCH2 | ||||||||||||||||||||||||||||||||
Accession | CVCL_8718 | ||||||||||||||||||||||||||||||||
Resource Identification Initiative | To cite this cell line use: HS-Sch-2 (RRID:CVCL_8718) | ||||||||||||||||||||||||||||||||
Comments | Problematic cell line: Misclassified. Originally thought to be a malignant peripheral nerve sheath tumor (MPNST) but shown to be from a desmplastic melanoma (PubMed=36818284). This is based on a number of criteria such as the result of a methylome-based classifier, the expression of the SOX10 and S100B markers, a WT status for PRC2 genes, the complete inactivation of NF1 and CDKN2A and negative staining for Melan-A. Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE). Population: Japanese. Doubling time: ~56 hours (PubMed=10891546). Karyotypic information: Average ploidy of 3.89 (PubMed=36818284). Omics: Genomics; Whole exome sequencing. Omics: Variations; SNP array analysis. Derived from site: Metastatic; Peripheral nervous system, left sciatic nerve; UBERON=UBERON_0001322. | ||||||||||||||||||||||||||||||||
Sequence variations |
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Disease | Desmoplastic melanoma (NCIt: C37257) | ||||||||||||||||||||||||||||||||
Species of origin | Homo sapiens (Human) (NCBI Taxonomy: 9606) | ||||||||||||||||||||||||||||||||
Sex of cell | Female | ||||||||||||||||||||||||||||||||
Age at sampling | 54Y | ||||||||||||||||||||||||||||||||
Category | Cancer cell line | ||||||||||||||||||||||||||||||||
STR profile | Source(s): PubMed=28556483; PubMed=33707600; PubMed=36818284; RCB=RCB2230 Markers:
Run an STR similarity search on this cell line | ||||||||||||||||||||||||||||||||
Publications | PubMed=10891546; DOI=10.3892/ijo.17.2.347 PubMed=28556483; DOI=10.1002/1878-0261.12086; PMCID=PMC5579334 PubMed=32642732; DOI=10.1093/noajnl/vdz049; PMCID=PMC7317054 PubMed=33707600; DOI=10.1038/s41598-021-85055-2; PMCID=PMC7952412 PubMed=34059954; DOI=10.1007/s00439-021-02296-x PubMed=36818284; DOI=10.1016/j.isci.2023.106096; PMCID=PMC9929861 | ||||||||||||||||||||||||||||||||
Cross-references | |||||||||||||||||||||||||||||||||
Cell line collections (Providers) | BCRJ; 0376
RCB; RCB2230 | ||||||||||||||||||||||||||||||||
Cell line databases/resources | CLO; CLO_0050146
cancercelllines; CVCL_8718 DepMap; ACH-002066 | ||||||||||||||||||||||||||||||||
Biological sample resources | BioSample; SAMN03472028 | ||||||||||||||||||||||||||||||||
Encyclopedic resources | Wikidata; Q54896291 | ||||||||||||||||||||||||||||||||
Polymorphism and mutation databases | IARC_TP53; 17934 | ||||||||||||||||||||||||||||||||
Entry history | |||||||||||||||||||||||||||||||||
Entry creation | 04-Apr-2012 | ||||||||||||||||||||||||||||||||
Last entry update | 10-Apr-2025 | ||||||||||||||||||||||||||||||||
Version number | 27 |