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Cellosaurus HS-Sch-2 (CVCL_8718)

[Text version]

Cell line name HS-Sch-2
Synonyms HS-sch-2; HSSCH2
Accession CVCL_8718
Resource Identification Initiative To cite this cell line use: HS-Sch-2 (RRID:CVCL_8718)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Population: Japanese.
Doubling time: ~56 hours (PubMed=10891546).
Derived from sampling site: Left sciatic nerve.
Sequence variations
  • Mutation; HGNC; 11998; TP53; Simple; p.Arg273His (c.818G>A); ClinVar=VCV000012366; Zygosity=Unspecified (PubMed=10891546; DepMap).
Disease Malignant peripheral nerve sheath tumor (NCIt: C3798)
Malignant peripheral nerve sheath tumor (ORDO: Orphanet_3148)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Age at sampling 54Y
Category Cancer cell line
STR profile Source(s): PubMed=28556483; PubMed=33707600; RCB

Markers:
AmelogeninX
CSF1PO11,13
D2S133820
D3S135818
D5S81813
D7S8208,11 (PubMed=28556483; RCB)
11 (PubMed=33707600)
D8S117914
D13S31711
D16S53911,12
D18S5113 (PubMed=33707600)
13,14 (PubMed=28556483)
D19S43310.2,14.2 (PubMed=33707600)
14.2 (PubMed=28556483)
D21S1129,30
FGA23,26
TH016,7
TPOX8
vWA15,16

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Publications

PubMed=10891546; DOI=10.3892/ijo.17.2.347
Sonobe H., Takeuchi T., Furihata M., Taguchi T., Kawai A., Ohjimi Y., Iwasaki H., Kaneko Y., Ohtsuki Y.
A new human malignant peripheral nerve sheath tumour-cell line, HS-Sch-2, harbouring p53 point mutation.
Int. J. Oncol. 17:347-352(2000)

PubMed=28556483; DOI=10.1002/1878-0261.12086
Kolberg M., Bruun J., Murumagi A., Mpindi J.P., Bergsland C.H., Holand M., Eilertsen I.A., Danielsen S.A., Kallioniemi O.-P., Lothe R.A.
Drug sensitivity and resistance testing identifies PLK1 inhibitors and gemcitabine as potent drugs for malignant peripheral nerve sheath tumors.
Mol. Oncol. 11:1156-1171(2017)

PubMed=32642732; DOI=10.1093/noajnl/vdz049
Pemov A., Li H., Presley W., Wallace M.R., Miller D.T.
Genetics of human malignant peripheral nerve sheath tumors.
Neurooncol. Adv. 2:I50-I61(2020)

PubMed=33707600; DOI=10.1038/s41598-021-85055-2
Longo J.F., Brosius S.N., Znoyko I., Alers V.A., Jenkins D.P., Wilson R.C., Carroll A.J., Wolff D.J., Roth K.A., Carroll S.L.
Establishment and genomic characterization of a sporadic malignant peripheral nerve sheath tumor cell line.
Sci. Rep. 11:5690-5690(2021)

Cross-references
Cell line collections BCRJ; 0376
RCB; RCB2230
Cell line databases/resources CLO; CLO_0050146
DepMap; ACH-002066
Biological sample resources BioSample; SAMN03472028
Encyclopedic resources Wikidata; Q54896291
Polymorphism and mutation databases IARC_TP53; 17934
Entry history
Entry creation04-Apr-2012
Last entry update16-Dec-2021
Version number20