Cellosaurus cell line HOC719 (CVCL

Cellosaurus HOC719 (CVCL_8700)

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Cell line name

HOC719

Accession

CVCL_8700

Resource Identification Initiative

To cite this cell line use: HOC719 (RRID:CVCL_8700)

Comments

Population: Japanese.
Derived from site: In situ; Oral cavity, tongue; UBERON=UBERON_0001723.

Sequence variations

Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.Met1043Val (c.3127A>G); ClinVar=VCV000376485; Zygosity=Homozygous (PubMed=18097548).
Mutation; HGNC; HGNC:11998; TP53; Simple; p.Asp281Glu (c.843C>G); ClinVar=VCV000376587; Zygosity=Unspecified (PubMed=1570156).

Disease

Tongue squamous cell carcinoma (NCIt: C4648)
Squamous cell carcinoma of the oral tongue (ORDO: Orphanet_457252)

Species of origin

Homo sapiens (Human) (NCBI Taxonomy: 9606)

Hierarchy

Children:

CVCL_8701 (HOC719-NE)

CVCL_8702 (HOC719-PE)

Category

Cancer cell line

Publications

PubMed=1570156
Eiki Sakai, Nobuo Tsuchida;
Most human squamous cell carcinomas in the oral cavity contain mutated p53 tumor-suppressor genes.
Oncogene 7:927-933(1992)

PubMed=11120485; DOI=10.1016/S1368-8375(00)00059-2
Kazuhiro Yokoyama, Nobuyuki Kamata, Eiji Hayashi, Toshiaki Hoteiya, Naohiro Ueda, Ryoichi Fujimoto, Masaru Nagayama;
Reverse correlation of E-cadherin and snail expression in oral squamous cell carcinoma cells in vitro.
Oral Oncol. 37:65-71(2001)

PubMed=18097548; DOI=10.3892/ijo.32.1.101
Avaniyapuram Kannan Murugan, Nguyen Thi Hong, Yasuhisa Fukui, Arasambattu Kannan Munirajan, Nobuo Tsuchida;
Oncogenic mutations of the PIK3CA gene in head and neck squamous cell carcinomas.
Int. J. Oncol. 32:101-111(2008)

Cross-references

Encyclopedic resources

Wikidata; Q54890116

Polymorphism and mutation databases

Cosmic; 1123034
IARC_TP53; 1098

Entry history

Entry creation

04-Apr-2012

Last entry update

19-Dec-2024

Version number