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Cellosaurus VACO 481 (CVCL_8638)

[Text version]
Cell line name VACO 481
Synonyms Vaco 481; VACO481; Vaco481; V481
Accession CVCL_8638
Resource Identification Initiative To cite this cell line use: VACO 481 (RRID:CVCL_8638)
Comments Microsatellite instability: Instable (MSI) (PubMed=25926053).
Omics: Transcriptomics; Microarray.
Sequence variations
  • Mutation; HGNC; HGNC:173; ACVR2A; Simple; p.Asp96fs*4 (c.278_279insA); Zygosity=Heterozygous (PubMed=12615714).
  • Mutation; HGNC; HGNC:173; ACVR2A; Simple; p.Lys437Argfs*5 (c.1310delA); dbSNP=rs764719749; Zygosity=Heterozygous (PubMed=12615714).
  • Mutation; HGNC; HGNC:11773; TGFBR2; Simple; p.Lys128Serfs*35 (c.383delA); ClinVar=VCV000477546; Zygosity=Heterozygous (PubMed=12615714).
  • Mutation; HGNC; HGNC:11773; TGFBR2; Simple; p.Ala535fs*30 (c.1597_1598TG[4]) (c.1602_1603insTG); ClinVar=VCV000012501; Zygosity=Heterozygous (PubMed=12615714).
  • Mutation; HGNC; HGNC:11998; TP53; None_reported; -; Zygosity=- (PubMed=9715273).
Disease Colon carcinoma (NCIt: C4910)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Category Cancer cell line
STR profile Source(s): PubMed=25926053

Markers:
AmelogeninX
CSF1PO7,12
D5S8188,11
D7S8208
D13S31711,13
D16S53911,15
D21S1131
TH017
TPOX8,9
vWA17,18,21

Run an STR similarity search on this cell line
Publications

PubMed=8385345; DOI=10.1073/pnas.90.7.2846; PMCID=PMC46193
Kelly J. Smith, Karen Audrey Johnson, Tracy M. Bryan, David E. Hill, Sanford David Markowitz, James K.V. Willson, Christos Paraskeva, Gloria Moy Petersen, Stanley R. Hamilton, Bert Vogelstein, Kenneth Wayne Kinzler;
The APC gene product in normal and tumor cells.
Proc. Natl. Acad. Sci. U.S.A. 90:2846-2850(1993)

PubMed=7704014; DOI=10.1038/ng0195-10
Luis Teixeira da Costa, Bo Liu, Wafik S. El-Deiry, Stanley R. Hamilton, Kenneth Wayne Kinzler, Bert Vogelstein, Sanford David Markowitz, James K.V. Willson, Albert de la Chapelle, Kathleen M. Downey, Antero G. So;
Polymerase delta variants in RER colorectal tumours.
Nat. Genet. 9:10-11(1995)

PubMed=7761852; DOI=10.1126/science.7761852
Sanford David Markowitz, Jing Wang, Lois Lemmermann Myeroff, Ramon Parsons, Lu-Zhe Sun, James D. Lutterbaugh, Robert S. Fan, Elizabeth Zborowska, Kenneth Wayne Kinzler, Bert Vogelstein, Michael G. Brattain, James K.V. Willson;
Inactivation of the type II TGF-beta receptor in colon cancer cells with microsatellite instability.
Science 268:1336-1338(1995)

PubMed=8755562; DOI=10.1073/pnas.93.15.7832; PMCID=PMC38834
Da-Cai Liu, Eric Pearlman, Eugenia Diaconu, Kun Guo, Hiroshi Mori, Tariq Haqqi, Sanford David Markowitz, James K.V. Willson, Man-Sun Sy;
Expression of hyaluronidase by tumor cells induces angiogenesis in vivo.
Proc. Natl. Acad. Sci. U.S.A. 93:7832-7837(1996)

PubMed=9515795
Andrew B. Sparks, Patrice J. Morin, Bert Vogelstein, Kenneth Wayne Kinzler;
Mutational analysis of the APC/beta-catenin/Tcf pathway in colorectal cancer.
Cancer Res. 58:1130-1134(1998)

PubMed=9715273; DOI=10.1038/sj.onc.1201986
James Richard Eshleman, Graham Casey, Mary E. Kochera, Wallace David Sedwick, Sandra E. Swinler, Martina L. Veigl, James K.V. Willson, Stuart Schwartz, Sanford David Markowitz;
Chromosome number and structure both are markedly stable in RER colorectal cancers and are not destabilized by mutation of p53.
Oncogene 17:719-725(1998)

PubMed=11314036; DOI=10.1038/sj.onc.1204211
Eva Forgacs, Jonathan D. Wren, Craig Kamibayashi, Masashi Kondo, Xie L. Xu, Sanford David Markowitz, Gail E. Tomlinson, Carolyn Y. Muller, Adi F. Gazdar, Harold Ray Garner, John D. Minna;
Searching for microsatellite mutations in coding regions in lung, breast, ovarian and colorectal cancers.
Oncogene 20:1005-1009(2001)

PubMed=12615714
Paula M. Hempen, Lin Zhang, Ravi K. Bansal, Christine A. Iacobuzio-Donahue, Kathleen M. Murphy, Anirban Maitra, Bert Vogelstein, Robert H. Whitehead, Sanford David Markowitz, James K.V. Willson, Charles J. Yeo ...Show all 13 authors... , Ralph H. Hruban, Scott E. Kern; Show fewer authors
Evidence of selection for clones having genetic inactivation of the activin A type II receptor (ACVR2) gene in gastrointestinal cancers.
Cancer Res. 63:994-999(2003)

PubMed=17363507; DOI=10.1158/1535-7163.MCT-06-0555
Jing Wang, Karen K. Kuropatwinski, Jennie Hauser, Michael R. Rossi, Yun-Fei Zhou, Alexis Conway, Julie L.C. Kan, Neil W. Gibson, James K.V. Willson, John Kenneth Cowell, Michael G. Brattain;
Colon carcinoma cells harboring PIK3CA mutations display resistance to growth factor deprivation induced apoptosis.
Mol. Cancer Ther. 6:1143-1150(2007)

PubMed=25926053; DOI=10.1038/ncomms8002
Enzo Medico, Mariangela Russo, Gabriele Picco, Carlotta Cancelliere, Emanuele Valtorta, Giorgio Corti, Michela Buscarino, Claudio Isella, Simona Lamba, Barbara Martinoglio, Silvio Veronese ...Show all 19 authors... , Salvatore Siena, Andrea Sartore-Bianchi, Marco Beccuti, Marcella Mottolese, Michael Linnebacher, Francesca Cordero, Federica Di Nicolantonio, Alberto Bardelli; Show fewer authors
The molecular landscape of colorectal cancer cell lines unveils clinically actionable kinase targets.
Nat. Commun. 6:7002.1-7002.10(2015)

Cross-references
Cell line databases/resources cancercelllines; CVCL_8638
ColonAtlas; VACO481
Encyclopedic resources Wikidata; Q54992758
Experimental variables resources EFO; EFO_0022534
Gene expression databases GEO; GSM1448110
Polymorphism and mutation databases Cosmic; 1090615
Cosmic; 1131690
Cosmic; 2646665
Cosmic; 2650773
Cosmic; 2667970
Cosmic; 2727477
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number22