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Cellosaurus VACO 444 (CVCL_8634)

[Text version]
Cell line name VACO 444
Synonyms Vaco 444; VACO444; V444
Accession CVCL_8634
Resource Identification Initiative To cite this cell line use: VACO 444 (RRID:CVCL_8634)
Sequence variations
  • Mutation; HGNC; HGNC:173; ACVR2A; Simple; p.Asp96fs*54 (c.278delA); Zygosity=Heterozygous (PubMed=12615714).
  • Mutation; HGNC; HGNC:173; ACVR2A; Simple; p.Lys437Argfs*5 (c.1310delA); dbSNP=rs764719749; Zygosity=Heterozygous (PubMed=12615714).
  • Mutation; HGNC; HGNC:11773; TGFBR2; Simple; p.Lys128Serfs*35 (c.383delA); ClinVar=VCV000477546; Zygosity=Homozygous (PubMed=12615714).
Disease Colon carcinoma (NCIt: C4910)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Category Cancer cell line
Publications

PubMed=8385345; DOI=10.1073/pnas.90.7.2846; PMCID=PMC46193
Kelly J. Smith, Karen Audrey Johnson, Tracy M. Bryan, David E. Hill, Sanford David Markowitz, James K.V. Willson, Christos Paraskeva, Gloria Moy Petersen, Stanley R. Hamilton, Bert Vogelstein, Kenneth Wayne Kinzler;
The APC gene product in normal and tumor cells.
Proc. Natl. Acad. Sci. U.S.A. 90:2846-2850(1993)

PubMed=7704014; DOI=10.1038/ng0195-10
Luis Teixeira da Costa, Bo Liu, Wafik S. El-Deiry, Stanley R. Hamilton, Kenneth Wayne Kinzler, Bert Vogelstein, Sanford David Markowitz, James K.V. Willson, Albert de la Chapelle, Kathleen M. Downey, Antero G. So;
Polymerase delta variants in RER colorectal tumours.
Nat. Genet. 9:10-11(1995)

PubMed=7761852; DOI=10.1126/science.7761852
Sanford David Markowitz, Jing Wang, Lois Lemmermann Myeroff, Ramon Parsons, Lu-Zhe Sun, James D. Lutterbaugh, Robert S. Fan, Elizabeth Zborowska, Kenneth Wayne Kinzler, Bert Vogelstein, Michael G. Brattain, James K.V. Willson;
Inactivation of the type II TGF-beta receptor in colon cancer cells with microsatellite instability.
Science 268:1336-1338(1995)

PubMed=8755562; DOI=10.1073/pnas.93.15.7832; PMCID=PMC38834
Da-Cai Liu, Eric Pearlman, Eugenia Diaconu, Kun Guo, Hiroshi Mori, Tariq Haqqi, Sanford David Markowitz, James K.V. Willson, Man-Sun Sy;
Expression of hyaluronidase by tumor cells induces angiogenesis in vivo.
Proc. Natl. Acad. Sci. U.S.A. 93:7832-7837(1996)

PubMed=9515795
Andrew B. Sparks, Patrice J. Morin, Bert Vogelstein, Kenneth Wayne Kinzler;
Mutational analysis of the APC/beta-catenin/Tcf pathway in colorectal cancer.
Cancer Res. 58:1130-1134(1998)

PubMed=12615714
Paula M. Hempen, Lin Zhang, Ravi K. Bansal, Christine A. Iacobuzio-Donahue, Kathleen M. Murphy, Anirban Maitra, Bert Vogelstein, Robert H. Whitehead, Sanford David Markowitz, James K.V. Willson, Charles J. Yeo ...Show all 13 authors... , Ralph H. Hruban, Scott E. Kern; Show fewer authors
Evidence of selection for clones having genetic inactivation of the activin A type II receptor (ACVR2) gene in gastrointestinal cancers.
Cancer Res. 63:994-999(2003)

Cross-references
Cell line databases/resources cancercelllines; CVCL_8634
Encyclopedic resources Wikidata; Q54992744
Polymorphism and mutation databases Cosmic; 1090614
Cosmic; 2667969
Cosmic; 2727475
Entry history
Entry creation04-Apr-2012
Last entry update19-Dec-2024
Version number15