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Cellosaurus SK-Neo (CVCL_8597)

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Cell line name SK-Neo
Synonyms SKNeo
Accession CVCL_8597
Resource Identification Initiative To cite this cell line use: SK-Neo (RRID:CVCL_8597)
Comments Population: Caucasian.
Genetic integration: Method=Transfection; Gene=UniProtKB; P00552; Klebsiella pneumoniae transposon Tn5 neo.
Derived from site: In situ; Vulva; UBERON=UBERON_0000997.
Sequence variations
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Met237Lys (c.710T>A); ClinVar=VCV000376636; Zygosity=Unspecified (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Gly245Ser (c.733G>A); ClinVar=VCV000012365; Zygosity=Unspecified (from parent cell line).
Disease Vulvar leiomyosarcoma (NCIt: C40318)
Leiomyosarcoma (ORDO: Orphanet_64720)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0628 (SK-LMS-1)
Sex of cell Female
Age at sampling 43Y
Category Cancer cell line
Publications

PubMed=9717829
Raphael E. Pollock, Ai-Qing Lang, Tong Ge, Dan-Tong Sun, Ming Tan, Di-Hua Yu;
Wild-type p53 and a p53 temperature-sensitive mutant suppress human soft tissue sarcoma by enhancing cell cycle control.
Clin. Cancer Res. 4:1985-1994(1998)

PubMed=17513613; DOI=10.1158/1535-7163.MCT-06-0636
Jonathan A.F. Hannay, Jeffrey Jue-Hui Liu, Quan-Sheng Zhu, Svetlana V. Bolshakov, Lan Li, Peter W.T. Pisters, Alexander J.F. Lazar, Di-Hua Yu, Raphael E. Pollock, Dina Chelouche Lev;
Rad51 overexpression contributes to chemoresistance in human soft tissue sarcoma cells: a role for p53/activator protein 2 transcriptional regulation.
Mol. Cancer Ther. 6:1650-1660(2007)

Cross-references
Cell line databases/resources cancercelllines; CVCL_8597
Encyclopedic resources Wikidata; Q54954486
Entry history
Entry creation04-Apr-2012
Last entry update14-Aug-2025
Version number19