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Cellosaurus RM10 (CVCL_8463)

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Cell line name RM10
Synonyms RM-10
Accession CVCL_8463
Resource Identification Initiative To cite this cell line use: RM10 (RRID:CVCL_8463)
Comments Problematic cell line: Contaminated. Shown to be a K-562 derivative (PubMed=10516762; PubMed=12592342; PubMed=20143388). Originally thought to originate from the bone marrow of a 44 year old female patient with chronic myelogenous leukemia.
Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00262.
Population: Caucasian.
Derived from site: In situ; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations
  • Gene fusion; HGNC; HGNC:76; ABL1 + HGNC; HGNC:1014; BCR; Name(s)=BCR-ABL1, BCR-ABL; Note=BCR exon 14 fused to ABL1 exon 2 (b3a2 transcript) (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Gln136fs*13 (c.406_407insC); Zygosity=Homozygous (from parent cell line).
Disease Blast phase chronic myelogenous leukemia, BCR-ABL1 positive (NCIt: C9110)
Chronic myeloid leukemia (ORDO: Orphanet_521)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0004 (K-562)
Sex of cell Female
Age at sampling 53Y
Category Cancer cell line
Web pages Info; ICLAC; -; https://iclac.org/wp-content/uploads/Cross-Contaminations_v13_distribution.xlsx
Publications

PubMed=2167410
Jouji Hirata, Hiroyuki Sato, Hiroyuki Takahira, Satoshi Shiokawa, Toshiyasu Endo, Junji Nishimura, Makoto Katsuno, Seiji Masuda, Ryoko Sasaki, Yasuyuki Fukumaki, Hajime Namata, Hiromitsu Okano;
A novel CD10-positive erythroid cell line, RM10, established from a patient with chronic myelogenous leukemia.
Leukemia 4:365-372(1990)

PubMed=10071072; DOI=10.1016/S0145-2126(98)00171-4
Hans Gunther Drexler, Roderick A.F. MacLeod, Cord C. Uphoff;
Leukemia cell lines: in vitro models for the study of Philadelphia chromosome-positive leukemia.
Leuk. Res. 23:207-215(1999)

PubMed=10516762; DOI=10.1038/sj.leu.2401510
Hans Gunther Drexler, Wilhelm Gerhard Dirks, Roderick A.F. MacLeod;
False human hematopoietic cell lines: cross-contaminations and misinterpretations.
Leukemia 13:1601-1607(1999)

PubMed=12592342; DOI=10.1038/sj.leu.2402799
Hans Gunther Drexler, Wilhelm Gerhard Dirks, Yoshinobu Matsuo, Roderick A.F. MacLeod;
False leukemia-lymphoma cell lines: an update on over 500 cell lines.
Leukemia 17:416-426(2003)

PubMed=20143388; DOI=10.1002/ijc.25242
Amanda Capes-Davis, George Theodosopoulos, Isobel Atkin, Hans Gunther Drexler, Arihiro Kohara, Roderick A.F. MacLeod, John R.W. Masters, Yukio Nakamura, Yvonne A. Reid, Roger Robert Reddel, Robert Ian Freshney;
Check your cultures! A list of cross-contaminated or misidentified cell lines.
Int. J. Cancer 127:1-8(2010)

Cross-references
Biological sample resources BioSample; SAMN03151811
Encyclopedic resources Wikidata; Q54950638
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number29