Cellosaurus cell line T-33 (CVCL

Cellosaurus T-33 (CVCL_8427)

Cross-references
Cell line name	T-33
Accession	CVCL_8427
Resource Identification Initiative	To cite this cell line use: T-33 (RRID:CVCL_8427)
Comments	Problematic cell line: Contaminated. Shown to be a K-562 derivative (PubMed=12592342; PubMed=20143388). Originally thought to originate from the peripheral blood of a 62 year old female patient with chronic myelogenous leukemia. Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00271. Population: Caucasian. Derived from site: In situ; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations	Gene fusion; HGNC; HGNC:76; ABL1 + HGNC; HGNC:1014; BCR; Name(s)=BCR-ABL1, BCR-ABL; Note=BCR exon 14 fused to ABL1 exon 2 (b3a2 transcript) (PubMed=10071072; PubMed=10576511). Mutation; HGNC; HGNC:11998; TP53; Simple; p.Gln136fs*13 (c.406_407insC); Zygosity=Homozygous (from parent cell line).
Disease	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive (NCIt: C9110) Chronic myeloid leukemia (ORDO: Orphanet_521)
Species of origin	Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy	Parent: CVCL_0004 (K-562)
Sex of cell	Female
Age at sampling	53Y
Category	Cancer cell line
Web pages	Info; ICLAC; -; https://iclac.org/wp-content/uploads/Cross-Contaminations_v13_distribution.xlsx
Publications	PubMed=3167860 Tsuyoshi Tange, Kazuhiko Nakahara, Kinuko Mitani, Ieharu Yamasaki, Hideyuki Yasuda, Fumihiko Tanaka, Masaru Mizuguchi, Hideaki Oda, Yutaka Yatomi, Riichiro Takanashi, Seitoku Fujioka ...Show all 13 authors... , Kazuyoshi Yamaguchi, Yoshinori Urano; Show fewer authors Establishment of a human megakaryoblastic cell line (T-33) from chronic myelogenous leukemia in megakaryoblastic crisis. Cancer Res. 48:6137-6144(1988) PubMed=10071072; DOI=10.1016/S0145-2126(98)00171-4 Hans Gunther Drexler, Roderick A.F. MacLeod, Cord C. Uphoff; Leukemia cell lines: in vitro models for the study of Philadelphia chromosome-positive leukemia. Leuk. Res. 23:207-215(1999) PubMed=10576511; DOI=10.1016/S0145-2126(99)00131-9 Cord C. Uphoff, Silke Habig, Severine Fombonne, Yoshinobu Matsuo, Hans Gunther Drexler; ABL-BCR expression in BCR-ABL-positive human leukemia cell lines. Leuk. Res. 23:1055-1060(1999) DOI=10.1016/B978-0-12-221970-2.50457-5 Hans Gunther Drexler; The leukemia-lymphoma cell line factsbook. (In book) ISBN 9780122219702; pp.1-733; Academic Press; London; United Kingdom (2001) PubMed=12592342; DOI=10.1038/sj.leu.2402799 Hans Gunther Drexler, Wilhelm Gerhard Dirks, Yoshinobu Matsuo, Roderick A.F. MacLeod; False leukemia-lymphoma cell lines: an update on over 500 cell lines. Leukemia 17:416-426(2003) PubMed=20143388; DOI=10.1002/ijc.25242 Amanda Capes-Davis, George Theodosopoulos, Isobel Atkin, Hans Gunther Drexler, Arihiro Kohara, Roderick A.F. MacLeod, John R.W. Masters, Yukio Nakamura, Yvonne A. Reid, Roger Robert Reddel, Robert Ian Freshney; Check your cultures! A list of cross-contaminated or misidentified cell lines. Int. J. Cancer 127:1-8(2010)
Biological sample resources	BioSample; SAMN03151816
Encyclopedic resources	Wikidata; Q54971338
Entry history
Entry creation	04-Apr-2012
Last entry update	10-Apr-2025
Version number	30