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Cellosaurus RS-1 [Human leukemia] (CVCL_8423)

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Cell line name RS-1 [Human leukemia]
Accession CVCL_8423
Resource Identification Initiative To cite this cell line use: RS-1 [Human leukemia] (RRID:CVCL_8423)
Comments Problematic cell line: Contaminated. Shown to be a K-562 derivative (PubMed=12592342; PubMed=20143388). Originally thought to originate from a 2 year old child with acute megakaryoblastic leukemia (AML-M7).
Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00264.
Population: Caucasian.
Derived from site: In situ; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations
  • Gene fusion; HGNC; HGNC:76; ABL1 + HGNC; HGNC:1014; BCR; Name(s)=BCR-ABL1, BCR-ABL; Note=BCR exon 14 fused to ABL1 exon 2 (b3a2 transcript) (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Gln136fs*13 (c.406_407insC); Zygosity=Homozygous (from parent cell line).
Disease Blast phase chronic myelogenous leukemia, BCR-ABL1 positive (NCIt: C9110)
Chronic myeloid leukemia (ORDO: Orphanet_521)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0004 (K-562)
Sex of cell Female
Age at sampling 53Y
Category Cancer cell line
Web pages Info; ICLAC; -; https://iclac.org/wp-content/uploads/Cross-Contaminations_v13_distribution.xlsx
Publications

PubMed=9210910; DOI=10.1159/000203557
Leo F. Skinnider, Paul Pabello, Chang-Yu Zheng;
Characteristics of a cell line established from a case of acute megakaryoblastic leukemia.
Acta Haematol. 98:26-31(1997)

PubMed=12592342; DOI=10.1038/sj.leu.2402799
Hans Gunther Drexler, Wilhelm Gerhard Dirks, Yoshinobu Matsuo, Roderick A.F. MacLeod;
False leukemia-lymphoma cell lines: an update on over 500 cell lines.
Leukemia 17:416-426(2003)

PubMed=20143388; DOI=10.1002/ijc.25242
Amanda Capes-Davis, George Theodosopoulos, Isobel Atkin, Hans Gunther Drexler, Arihiro Kohara, Roderick A.F. MacLeod, John R.W. Masters, Yukio Nakamura, Yvonne A. Reid, Roger Robert Reddel, Robert Ian Freshney;
Check your cultures! A list of cross-contaminated or misidentified cell lines.
Int. J. Cancer 127:1-8(2010)

Cross-references
Biological sample resources BioSample; SAMN03151812
Encyclopedic resources Wikidata; Q54951292
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number28