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Cellosaurus ATL-43T (CVCL_8340)

[Text version]
Cell line name ATL-43T
Synonyms ATL43T
Accession CVCL_8340
Resource Identification Initiative To cite this cell line use: ATL-43T (RRID:CVCL_8340)
Comments Population: Japanese.
Characteristics: Lost its original IL2 dependency.
Transformant: NCBI_TaxID; 11908; Human T-lymphotropic virus 1 (HTLV-1).
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Cell type: T-cell; CL=CL_0000084.
Disease Adult T-cell leukemia/lymphoma (NCIt: C3184)
Adult T-cell leukemia/lymphoma (ORDO: Orphanet_86875)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Sex unspecified
Age at sampling Adult
Category Cancer cell line
Publications

PubMed=7662981; DOI=10.1182/blood.V86.6.2350.bloodjournal8662350
Imada K., Takaori-Kondo A., Akagi T., Shimotohno K., Sugamura K., Hattori T., Yamabe H., Okuma M., Uchiyama T.
Tumorigenicity of human T-cell leukemia virus type I-infected cell lines in severe combined immunodeficient mice and characterization of the cells proliferating in vivo.
Blood 86:2350-2357(1995)

PubMed=10706122
Nosaka K., Maeda M., Tamiya S., Sakai T., Mitsuya H., Matsuoka M.
Increasing methylation of the CDKN2A gene is associated with the progression of adult T-cell leukemia.
Cancer Res. 60:1043-1048(2000)

PubMed=15638850; DOI=10.1111/j.1365-2141.2004.05255.x
Ueda M., Imada K., Imura A., Koga H., Hishizawa M., Uchiyama T.
Expression of functional interleukin-21 receptor on adult T-cell leukaemia cells.
Br. J. Haematol. 128:169-176(2005)

PubMed=16314839; DOI=10.1038/sj.onc.1209256
Ahsan M.K., Masutani H., Yamaguchi Y., Kim Y.-C., Nosaka K., Matsuoka M., Nishinaka Y., Maeda M., Yodoi J.
Loss of interleukin-2-dependency in HTLV-I-infected T cells on gene silencing of thioredoxin-binding protein-2.
Oncogene 25:2181-2191(2006)

PubMed=32210945; DOI=10.3389/fmicb.2020.00356; PMCID=PMC7067701
Maeda M., Tanabe-Shibuya J., Miyazato P., Masutani H., Yasunaga J.-i., Usami K., Shimizu A., Matsuoka M.
IL-2/IL-2 receptor pathway plays a crucial role in the growth and malignant transformation of HTLV-1-infected T cells to develop adult T-cell leukemia.
Front. Microbiol. 11:356.1-356.17(2020)

Cross-references
Encyclopedic resources Wikidata; Q54751266
Entry history
Entry creation04-Apr-2012
Last entry update29-Jun-2023
Version number14