Cellosaurus cell line IMC-4 (CVCL

Cellosaurus IMC-4 (CVCL_8247)

Cross-references
Cell line name	IMC-4
Accession	CVCL_8247
Resource Identification Initiative	To cite this cell line use: IMC-4 (RRID:CVCL_8247)
Comments	Problematic cell line: Contaminated. Shown to be a HeLa derivative (PubMed=20143388). Originally thought to originate from a male patient (from which IMC-2 and IMC-3 were also supposed to be derived) with maxillary carcinoma. Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00319. Population: African American. Transformant: NCBI_TaxID; 333761; Human papillomavirus type 18 (HPV18). Derived from site: In situ; Uterus, cervix; UBERON=UBERON_0000002.
Disease	Human papillomavirus-related endocervical adenocarcinoma (NCIt: C27677)
Species of origin	Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy	Parent: CVCL_0030 (HeLa)
Sex of cell	Female
Age at sampling	30Y6M
Category	Cancer cell line
Web pages	Info; ICLAC; -; https://iclac.org/wp-content/uploads/Cross-Contaminations_v13_distribution.xlsx
Publications	PubMed=1610070; DOI=10.1177/000348949210100613 Komiyama S., Matsui K., Miyazaki H., Kudoh S., Mizoguchi H., Shimizu N. Heterogeneity in epidermal growth factor responsiveness and tumor growth of human maxillary cancer cell lines. Ann. Otol. Rhinol. Laryngol. 101:519-524(1992) PubMed=20143388; DOI=10.1002/ijc.25242 Capes-Davis A., Theodosopoulos G., Atkin I., Drexler H.G., Kohara A., MacLeod R.A.F., Masters J.R.W., Nakamura Y., Reid Y.A., Reddel R.R., Freshney R.I. Check your cultures! A list of cross-contaminated or misidentified cell lines. Int. J. Cancer 127:1-8(2010)
Cell line collections (Providers)	RCB; RCB0728 - Discontinued
Biological sample resources	BioSample; SAMN03151722
Encyclopedic resources	Wikidata; Q54897518
Entry history
Entry creation	04-Apr-2012
Last entry update	10-Apr-2025
Version number	23