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Cellosaurus IMC-3 (CVCL_8246)

[Text version]
Cell line name IMC-3
Accession CVCL_8246
Resource Identification Initiative To cite this cell line use: IMC-3 (RRID:CVCL_8246)
Comments Problematic cell line: Contaminated. Shown to be a HeLa derivative (PubMed=20143388). Originally thought to originate from a male patient (from which IMC-2 and IMC-4 were also supposed to be derived) with maxillary carcinoma.
Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00215.
Population: African American.
Transformant: NCBI_TaxID; 333761; Human papillomavirus type 18 (HPV18).
Derived from site: In situ; Uterus, cervix; UBERON=UBERON_0000002.
Disease Human papillomavirus-related endocervical adenocarcinoma (NCIt: C27677)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0030 (HeLa)
Sex of cell Female
Age at sampling 30Y6M
Category Cancer cell line
STR profile Source(s): PubMed=11416159

Markers:
AmelogeninX
D8S117912
D18S5116
D21S1127,28
FGA18,21
TH017
vWA16,19

Run an STR similarity search on this cell line
Web pages Info; ICLAC; -; https://iclac.org/wp-content/uploads/Cross-Contaminations_v13_distribution.xlsx
Publications

PubMed=1610070; DOI=10.1177/000348949210100613
Sohtaro Komiyama, Katsuko Matsui, Hiroshi Miyazaki, Shohji Kudoh, Hiromoto Mizoguchi, Nobuyoshi Shimizu;
Heterogeneity in epidermal growth factor responsiveness and tumor growth of human maxillary cancer cell lines.
Ann. Otol. Rhinol. Laryngol. 101:519-524(1992)

PubMed=11416159; DOI=10.1073/pnas.121616198; PMCID=PMC35459
John R.W. Masters, Jim A. Thomson, Bernadette Daly-Burns, Yvonne A. Reid, Wilhelm Gerhard Dirks, Phil Packer, Lorraine H. Toji, Tadao Ohno, Hideyuki Tanabe, Colin Francis Arlett, Lloyd R. Kelland ...Show all 16 authors... , Maureen Harrison, Arvind K. Virmani, Timothy H. Ward, Karen L. Ayres, Paul G. Debenham; Show fewer authors
Short tandem repeat profiling provides an international reference standard for human cell lines.
Proc. Natl. Acad. Sci. U.S.A. 98:8012-8017(2001)

PubMed=20143388; DOI=10.1002/ijc.25242
Amanda Capes-Davis, George Theodosopoulos, Isobel Atkin, Hans Gunther Drexler, Arihiro Kohara, Roderick A.F. MacLeod, John R.W. Masters, Yukio Nakamura, Yvonne A. Reid, Roger Robert Reddel, Robert Ian Freshney;
Check your cultures! A list of cross-contaminated or misidentified cell lines.
Int. J. Cancer 127:1-8(2010)

Cross-references
Cell line collections (Providers) RCB; RCB0727 - Discontinued
Biological sample resources BioSample; SAMN03151721
Encyclopedic resources Wikidata; Q54897517
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number23