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Cellosaurus IMC-2 (CVCL_8245)

[Text version]
Cell line name IMC-2
Synonyms IMC2
Accession CVCL_8245
Resource Identification Initiative To cite this cell line use: IMC-2 (RRID:CVCL_8245)
Comments Problematic cell line: Contaminated. Shown to be a HeLa derivative (PubMed=10508494; PubMed=20143388). Originally thought to originate from a male patient (from which IMC-3 and IMC-4 were also supposed to be derived) with maxillary carcinoma.
Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00134.
Population: African American.
Transformant: NCBI_TaxID; 333761; Human papillomavirus type 18 (HPV18).
Derived from site: In situ; Uterus, cervix; UBERON=UBERON_0000002.
Disease Human papillomavirus-related cervical adenocarcinoma (NCIt: C27677)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0030 (HeLa)
Sex of cell Female
Age at sampling 30Y6M
Category Cancer cell line
Web pages https://iclac.org/wp-content/uploads/Cross-Contaminations_v13_distribution.xlsx

PubMed=1610070; DOI=10.1177/000348949210100613
Komiyama S., Matsui K., Miyazaki H., Kudoh S., Mizoguchi H., Shimizu N.
Heterogeneity in epidermal growth factor responsiveness and tumor growth of human maxillary cancer cell lines.
Ann. Otol. Rhinol. Laryngol. 101:519-524(1992)

PubMed=10508494; DOI=10.1002/(SICI)1097-0215(19991112)83:4<555::AID-IJC19>3.0.CO;2-2
MacLeod R.A.F., Dirks W.G., Matsuo Y., Kaufmann M., Milch H., Drexler H.G.
Widespread intraspecies cross-contamination of human tumor cell lines arising at source.
Int. J. Cancer 83:555-563(1999)

PubMed=20143388; DOI=10.1002/ijc.25242
Capes-Davis A., Theodosopoulos G., Atkin I., Drexler H.G., Kohara A., MacLeod R.A.F., Masters J.R.W., Nakamura Y., Reid Y.A., Reddel R.R., Freshney R.I.
Check your cultures! A list of cross-contaminated or misidentified cell lines.
Int. J. Cancer 127:1-8(2010)

Cell line collections (Providers) RCB; RCB0726 - Discontinued
Biological sample resources BioSample; SAMN03151720
Encyclopedic resources Wikidata; Q54897516
Entry history
Entry creation04-Apr-2012
Last entry update02-May-2024
Version number24