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Cellosaurus IMC-2 (CVCL_8245)

[Text version]
Cell line name IMC-2
Synonyms IMC2
Accession CVCL_8245
Resource Identification Initiative To cite this cell line use: IMC-2 (RRID:CVCL_8245)
Comments Problematic cell line: Contaminated. Shown to be a HeLa derivative (PubMed=10508494; PubMed=20143388). Originally thought to originate from a male patient (from which IMC-3 and IMC-4 were also supposed to be derived) with maxillary carcinoma.
Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00134.
Population: African American.
Transformant: NCBI_TaxID; 333761; Human papillomavirus type 18 (HPV18).
Derived from site: In situ; Uterus, cervix; UBERON=UBERON_0000002.
Disease Human papillomavirus-related endocervical adenocarcinoma (NCIt: C27677)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0030 (HeLa)
Sex of cell Female
Age at sampling 30Y6M
Category Cancer cell line
Web pages Info; ICLAC; -; https://iclac.org/wp-content/uploads/Cross-Contaminations_v13_distribution.xlsx
Publications

PubMed=1610070; DOI=10.1177/000348949210100613
Sohtaro Komiyama, Katsuko Matsui, Hiroshi Miyazaki, Shohji Kudoh, Hiromoto Mizoguchi, Nobuyoshi Shimizu;
Heterogeneity in epidermal growth factor responsiveness and tumor growth of human maxillary cancer cell lines.
Ann. Otol. Rhinol. Laryngol. 101:519-524(1992)

PubMed=10508494; DOI=10.1002/(SICI)1097-0215(19991112)83:4<555::AID-IJC19>3.0.CO;2-2
Roderick A.F. MacLeod, Wilhelm Gerhard Dirks, Yoshinobu Matsuo, Maren Kaufmann, Herbert Milch, Hans Gunther Drexler;
Widespread intraspecies cross-contamination of human tumor cell lines arising at source.
Int. J. Cancer 83:555-563(1999)

PubMed=20143388; DOI=10.1002/ijc.25242
Amanda Capes-Davis, George Theodosopoulos, Isobel Atkin, Hans Gunther Drexler, Arihiro Kohara, Roderick A.F. MacLeod, John R.W. Masters, Yukio Nakamura, Yvonne A. Reid, Roger Robert Reddel, Robert Ian Freshney;
Check your cultures! A list of cross-contaminated or misidentified cell lines.
Int. J. Cancer 127:1-8(2010)

Cross-references
Cell line collections (Providers) RCB; RCB0726 - Discontinued
Biological sample resources BioSample; SAMN03151720
Encyclopedic resources Wikidata; Q54897516
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number25