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Cellosaurus HB11;19 (CVCL_8227)

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Cell line name HB11;19
Synonyms HB(11;19); HB11.19; HB 11;19; HB1119
Accession CVCL_8227
Resource Identification Initiative To cite this cell line use: HB11;19 (RRID:CVCL_8227)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Omics: Genomics; Whole exome sequencing.
Omics: Variations; Array-based CGH.
Sequence variations
  • Gene fusion; HGNC; HGNC:7132; KMT2A + HGNC; HGNC:7134; MLLT1; Name(s)=KMT2A-MLLT1, MLL-MLLT1, MLL-ENL (PubMed=1423624; PubMed=16523483; DepMap=ACH-001736).
  • Mutation; HGNC; HGNC:1787; CDKN2A; Simple; p.Arg80Ter (c.237_238CC>TT) (c.237_238delinsTT) (p.Pro94Leu, c.280_281CC>TT); Zygosity=Homozygous (DepMap=ACH-001736).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Thr125Met (c.374C>T); ClinVar=VCV000183748; Zygosity=Unspecified (DepMap=ACH-001736).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg248Trp (c.742C>T); ClinVar=VCV000012347; Zygosity=Unspecified (DepMap=ACH-001736).
Disease B acute lymphoblastic leukemia with t(v;11q23.3) MLL rearranged (NCIt: C80342)
B-lymphoblastic leukemia/lymphoma with t(v;11q23.3) (ORDO: Orphanet_585918)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Sex unspecified
Age at sampling Age unspecified
Category Cancer cell line
Publications

PubMed=1423624; DOI=10.1016/0092-8674(92)90602-9
Douglas Cameron Tkachuk, Sabine Kohler, Michael L. Cleary;
Involvement of a homolog of Drosophila trithorax by 11q23 chromosomal translocations in acute leukemias.
Cell 71:691-700(1992)

PubMed=16523483; DOI=10.1002/gcc.20317
Sharon W. Horsley, Alan Mackay, Marjan Iravani, Kerry Fenwick, Haukur Valgeirsson, Tim J. Dexter, Alan Ashworth, Lyndal Kearney;
Array CGH of fusion gene-positive leukemia-derived cell lines reveals cryptic regions of genomic gain and loss.
Genes Chromosomes Cancer 45:554-564(2006)

Cross-references
Cell line databases/resources cancercelllines; CVCL_8227
Cell_Model_Passport; SIDM01428
DepMap; ACH-001736
Encyclopedic resources Wikidata; Q54881357
Experimental variables resources EFO; EFO_0022450
Entry history
Entry creation04-Apr-2012
Last entry update14-Aug-2025
Version number22