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Cellosaurus HN-4 (CVCL_8127)

[Text version]
Cell line name HN-4
Synonyms HN4; LICR-LON-HN4; LICR (LON) HN4; LICR-HN-4
Accession CVCL_8127
Resource Identification Initiative To cite this cell line use: HN-4 (RRID:CVCL_8127)
Comments Part of: MD Anderson Cell Lines Project.
Doubling time: 100 hours (PubMed=7195729).
Omics: Genomics; Whole exome sequencing.
Omics: Proteomics; Expression; Reverse-phase protein array.
Omics: Transcriptomics; RNAseq.
Derived from site: In situ; Larynx; UBERON=UBERON_0001737.
Disease Laryngeal squamous cell carcinoma (NCIt: C4044)
Squamous cell carcinoma of the larynx (ORDO: Orphanet_494550)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 57Y
Category Cancer cell line
STR profile Source(s): PubMed=21868764

Markers:
AmelogeninX
CSF1PO10,11
D5S81811,12
D7S82010
D13S31713
D16S5399,12
TH017,9
TPOX11
vWA16,17

Run an STR similarity search on this cell line
Web pages Info; MCLP; -; https://tcpaportal.org/mclp/
Publications

PubMed=7195729; DOI=10.1038/bjc.1981.115; PMCID=PMC2010719
Dorothy M. Easty, Gerald C. Easty, Richard Lawrance Carter, Paul Monaghan, Leslie J. Butler;
Ten human carcinoma cell lines derived from squamous carcinomas of the head and neck.
Br. J. Cancer 43:772-785(1981)

PubMed=2427339; DOI=10.1016/0277-5379(86)90158-6
Dorothy M. Easty, Gerald C. Easty, Antonio Baici, Richard Lawrance Carter, Stewart Anthony Cederholm-Williams, Heidi Felix, Barry Austin Gusterson, Gisela Haemmerli, Ingrid Helen Hauser-Urfer, Claus W. Heizmann, Marc M. Mareel ...Show all 13 authors... , B. Stehrenberger, Peter Strauli; Show fewer authors
Biological studies of ten human squamous carcinoma cell lines: an overview.
Eur. J. Cancer Clin. Oncol. 22:617-634(1986)

DOI=10.1016/B978-0-12-333530-2.50007-1
Thomas E. Carey;
Head and neck tumor cell lines.
(In book chapter) Atlas of human tumor cell lines; Hay, Robert J. & Park, Jae-Gahb & Gazdar, Adi F. (eds.); pp.79-120; Academic Press; New York; USA (1994)

PubMed=21868764; DOI=10.1158/1078-0432.CCR-11-0690; PMCID=PMC3229662
Mei Zhao, Daisuke Sano, Curtis R. Pickering, Samar A. Jasser, Ying C. Henderson, Gary L. Clayman, Erich M. Sturgis, Thomas J. Ow, Reuben Lotan, Thomas E. Carey, Peter G. Sacks ...Show all 15 authors... , Jennifer Rubin Grandis, David Sidransky, Nils-Erik Heldin, Jeffrey N. Myers; Show fewer authors
Assembly and initial characterization of a panel of 85 genomically validated cell lines from diverse head and neck tumor sites.
Clin. Cancer Res. 17:7248-7264(2011)

PubMed=26754630; DOI=10.1186/s13046-016-0284-4; PMCID=PMC4709939
Hiroshi Hyakusoku, Daisuke Sano, Hideaki Takahashi, Takashi Hatano, Yasuhiro Isono, Shoko Shimada, Yusuke Ito, Jeffrey N. Myers, Nobuhiko Oridate;
JunB promotes cell invasion, migration and distant metastasis of head and neck squamous cell carcinoma.
J. Exp. Clin. Cancer Res. 35:6.1-6.12(2016)

PubMed=28196595; DOI=10.1016/j.ccell.2017.01.005; PMCID=PMC5501076
Jun Li, Wei Zhao, Rehan Akbani, Wen-Bin Liu, Zhen-Lin Ju, Shi-Yun Ling, Christopher P. Vellano, Paul Roebuck, Qing-Hua Yu, A. Karina Eterovic, Lauren Averett Byers ...Show all 25 authors... , Michael A. Davies, Wan-Leng Deng, Y.N. Vashisht Gopal, Guo Chen, Erika Maria von Euw, Dennis Joseph Slamon, Dylan Conklin, John Victor Heymach, Adi F. Gazdar, John D. Minna, Jeffrey N. Myers, Yi-Ling Lu, Gordon B. Mills, Han Liang; Show fewer authors
Characterization of human cancer cell lines by reverse-phase protein arrays.
Cancer Cell 31:225-239(2017)

PubMed=29156801; DOI=10.18632/oncotarget.21174; PMCID=PMC5689691
Nene N. Kalu, Tuhina Mazumdar, Shao-Hua Peng, Li Shen, Vaishnav Sambandam, Xia-Yu Rao, Yuan-Xin Xi, Le-Rong Li, Yuan Qi, Frederico O. Gleber-Netto, Ameeta Patel ...Show all 16 authors... , Jing Wang, Mitchell J. Frederick, Jeffrey N. Myers, Curtis R. Pickering, Faye M. Johnson; Show fewer authors
Genomic characterization of human papillomavirus-positive and -negative human squamous cell cancer cell lines.
Oncotarget 8:86369-86383(2017)

Cross-references
Encyclopedic resources Wikidata; Q54889992
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number21