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Cellosaurus FL-318 (CVCL_8095)

[Text version]
Cell line name FL-318
Synonyms FL318
Accession CVCL_8095
Resource Identification Initiative To cite this cell line use: FL-318 (RRID:CVCL_8095)
Comments Population: Japanese.
Doubling time: 45.2 hours (PubMed=8847894).
Omics: Array-based CGH.
Omics: CNV analysis.
Omics: miRNA expression profiling.
Omics: Transcriptome analysis by microarray.
Misspelling: AKA96-9; IARC_TP53=6005; Note=Not really a misspelling but an assignment of a name based on first author of publication and date because assignment of correct cell line name was not done correctly.
Derived from site: In situ; Ascites; UBERON=UBERON_0007795.
Sequence variations
  • Gene fusion; HGNC; 990; BCL2 + HGNC; 5477; IGH; Name(s)=IGH-BCL2 (PubMed=12967475).
  • Mutation; HGNC; 11998; TP53; Simple; p.Val274Leu (c.820G>C); ClinVar=VCV000376678; Zygosity=Unspecified (PubMed=8878455).
Disease Follicular lymphoma (NCIt: C3209)
Follicular lymphoma (ORDO: Orphanet_545)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 67Y
Category Cancer cell line

Amakawa R., Fukuhara S., Ohno H., Tanabe S., Horii M., Matsuyama F., Kato I., Kakita T., Nagauchi O.
Amplified and rearranged bcl-2 gene in two lymphoma cell lines, FL-218 and FL-318, carrying a 14;18 translocation.
Cancer Res. 50:2423-2428(1990)

Tani A., Tatsumi E., Nakamura F., Kumagai S., Kosaka Y., Sano K., Nakamura H., Amakawa R., Ohno H.
Sensitivity to dexamethasone and absence of bcl-2 protein in Burkitt's lymphoma cell line (Black93) derived from a patient with acute tumor lysis syndrome: comparative study with other BL and non-BL lines.
Leukemia 10:1592-1603(1996)

PubMed=8878455; DOI=10.1111/j.1349-7006.1996.tb02122.x
Akasaka T., Muramatsu M., Kadowaki N., Ohno H., Ishizaki K., Yamabe H., Fukuhara S., Okuma M.
p53 mutation in B-cell lymphoid neoplasms with reference to oncogene rearrangements associated with chromosomal translocations.
Jpn. J. Cancer Res. 87:930-937(1996)

Drexler H.G.
The leukemia-lymphoma cell line factsbook.
(In) ISBN 9780122219702; pp.1-733; Academic Press; London (2001)

PubMed=12967475; DOI=10.1111/j.1349-7006.2003.tb01518.x
Maesako Y., Uchiyama T., Ohno H.
Comparison of gene expression profiles of lymphoma cell lines from transformed follicular lymphoma, Burkitt's lymphoma and de novo diffuse large B-cell lymphoma.
Cancer Sci. 94:774-781(2003)

PubMed=14990977; DOI=10.1038/sj.leu.2403323
Hardianti M.S., Tatsumi E., Syampurnawati M., Furuta K., Saigo K., Nakamachi Y., Kumagai S., Ohno H., Tanabe S., Uchida M., Yasuda N.
Activation-induced cytidine deaminase expression in follicular lymphoma: association between AID expression and ongoing mutation in FL.
Leukemia 18:826-831(2004)

PubMed=19278952; DOI=10.1182/blood-2009-01-202028
Li C., Kim S.-W., Rai D., Bolla A.R., Adhvaryu S., Kinney M.C., Robetorye R.S., Aguiar R.C.T.
Copy number abnormalities, MYC activity, and the genetic fingerprint of normal B cells mechanistically define the microRNA profile of diffuse large B-cell lymphoma.
Blood 113:6681-6690(2009)

Cell line databases/resources cancercelllines; CVCL_8095
Anatomy/cell type resources BTO; BTO:0002520
Encyclopedic resources Wikidata; Q54834955
Gene expression databases GEO; GSM380126
Polymorphism and mutation databases IARC_TP53; 6005
Entry history
Entry creation04-Apr-2012
Last entry update05-Oct-2023
Version number18