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Cellosaurus 526-mel (CVCL_8051)

[Text version]
Cell line name 526-mel
Synonyms 526-MEL; 526 mel; 526mel; 526MEL; 526; MEL-526; Mel526; MEL526
Accession CVCL_8051
Resource Identification Initiative To cite this cell line use: 526-mel (RRID:CVCL_8051)
Comments From: Rosenberg, Steven A.; Surgery Branch, National Cancer Institute, National Institutes of Health; Bethesda; USA.
Omics: Proteomics; 2DE-MS.
Omics: Transcriptomics; Microarray.
Omics: Variations; Array-based CGH.
Misspelling: 527MEL; GEO=GSM206440.
Derived from site: Metastatic; Not specified.
Sequence variations
HLA typing Source: PubMed=9670966
Class I
HLA-AA*02:01,03
HLA-BB*50,62
HLA-CC*03
Disease Melanoma (NCIt: C3224)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Sex unspecified
Age at sampling Age unspecified
Category Cancer cell line
STR profile Source(s): Technion Genomics Center

Markers:
AmelogeninX
CSF1PO11,12
D1S165617.3,18.3
D2S44111,14
D2S133819,24
D3S135815,19
D5S81811,13
D7S8209,12
D8S117914
D10S124815
D12S39117,20
D13S31712
D16S53911
D18S5116,17
D19S43314
D21S1129,31.2
D22S104511,16
FGA22
Penta D9,12
Penta E16,18
TH019.3
TPOX11,12
vWA15,18

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Publications

PubMed=8027550; DOI=10.4049/jimmunol.153.3.1225
Francesco M. Marincola, Peter Shamamian, Richard B. Alexander, James R. Gnarra, Regina L. Turetskaya, Sergei Arturovich Nedospasov, Toni B. Simonis, Jeffery Karl Taubenberger, John R. Yannelli, Arnold Mixon, Nicholas P. Restifo ...Show all 13 authors... , Meenhard Herlyn, Steven A. Rosenberg; Show fewer authors
Loss of HLA haplotype and B locus down-regulation in melanoma cell lines.
J. Immunol. 153:1225-1237(1994)

PubMed=8081556; DOI=10.1097/00002371-199407000-00002; PMCID=PMC2561308
Francesco M. Marincola, Peter Shamamian, Toni B. Simonis, Andrea D. Abati, Julia A. Hackett, Teresita O'Dea, Patricia A. Fetsch, John R. Yannelli, Nicholas P. Restifo, James J. Mule, Steven A. Rosenberg;
Locus-specific analysis of human leukocyte antigen class I expression in melanoma cell lines.
J. Immunother. Emphasis Tumor Immunol. 16:13-23(1994)

PubMed=8537970; DOI=10.1093/jnci/88.2.100; PMCID=PMC2248456
Nicholas P. Restifo, Francesco M. Marincola, Yutaka Kawakami, Jeffery Karl Taubenberger, John R. Yannelli, Steven A. Rosenberg;
Loss of functional beta 2-microglobulin in metastatic melanomas from five patients receiving immunotherapy.
J. Natl. Cancer Inst. 88:100-108(1996)

PubMed=9598804; DOI=10.1002/(SICI)1098-2264(199806)22:2<157::AID-GCC11>3.0.CO;2-N
Graeme J. Walker, Jose F. Flores, J. Michael Glendening, Amy Hsiu-Ti Lin, Isabel D.C. Markl, Jane W. Fountain;
Virtually 100% of melanoma cell lines harbor alterations at the DNA level within CDKN2A, CDKN2B, or one of their downstream targets.
Genes Chromosomes Cancer 22:157-163(1998)

PubMed=9670966; DOI=10.4049/jimmunol.161.2.877
Maria P. Bettinotti, Christina J. Kim, Kang-Hun Lee, Matthew Roden, Janice N. Cormier, Monica C. Panelli, Kenneth K. Parker, Francesco M. Marincola;
Stringent allele/epitope requirements for MART-1/Melan A immunodominance: implications for peptide-based immunotherapy.
J. Immunol. 161:877-889(1998)

PubMed=10048982; DOI=10.1002/(SICI)1097-0215(19990301)80:5<781::AID-IJC24>3.0.CO;2-A; PMCID=PMC2072935
Janice N. Cormier, Monica C. Panelli, Julia A. Hackett, Maria P. Bettinotti, Arnold Mixon, John R. Wunderlich, Linda L. Parker, Nicholas P. Restifo, Soldano Ferrone, Francesco M. Marincola;
Natural variation of the expression of HLA and endogenous antigen modulates CTL recognition in an in vitro melanoma model.
Int. J. Cancer 80:781-790(1999)

PubMed=15467732; DOI=10.1038/sj.onc.1208152
Hideaki Tanami, Issei Imoto, Akira Hirasawa, Yasuhiro Yuki, Itaru Sonoda, Jun Inoue, Kohichiroh Yasui, Akiko Misawa-Furihata, Yutaka Kawakami, Johji Inazawa;
Involvement of overexpressed wild-type BRAF in the growth of malignant melanoma cell lines.
Oncogene 23:8796-8804(2004)

PubMed=18172304; DOI=10.1158/0008-5472.CAN-07-1939
Marianna Sabatino, Ying-Dong Zhao, Sonia Voiculescu, Alessandro Monaco, Paul F. Robbins, Laszlo Karai, Brian J. Nickoloff, Michele Maio, Silvia Selleri, Francesco M. Marincola, Ena Wang;
Conservation of genetic alterations in recurrent melanoma supports the melanoma stem cell hypothesis.
Cancer Res. 68:122-131(2008)

PubMed=21857157; DOI=10.4161/cc.10.17.17068; PMCID=PMC5479465
Emilia Caputo, Luigi Maiorana, Valeria Vasta, Franca Maria Pezzino, Sudhir Sunkara, Kieran Wynne, Giuliano Elia, Francesco M. Marincola, James Andrew McCubrey, Massimo Libra, Salvatore Travali, Marian Kane;
Characterization of human melanoma cell lines and melanocytes by proteome analysis.
Cell Cycle 10:2924-2936(2011)

Cross-references
Cell line databases/resources cancercelllines; CVCL_8051
CGH-DB; 9297-4
Encyclopedic resources Wikidata; Q54603719
Gene expression databases GEO; GSM206440
GEO; GSM218052
Polymorphism and mutation databases Cosmic; 905211
Cosmic; 1303043
Progenetix; CVCL_8051
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number27