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Cellosaurus TTC-549 (CVCL_8005)

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Cell line name TTC-549
Synonyms TTC 549; TTC549
Accession CVCL_8005
Resource Identification Initiative To cite this cell line use: TTC-549 (RRID:CVCL_8005)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: ENCODE project common cell types; tier 3.
Omics: Genomics; Whole exome sequencing.
Omics: Transcriptomics; RNAseq.
Omics: Variations; SNP array analysis.
Derived from site: In situ; Liver; UBERON=UBERON_0002107.
Sequence variations
Disease Extrarenal rhabdoid tumor (NCIt: C6586)
Rhabdoid tumor (ORDO: Orphanet_69077)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Age at sampling 6M
Category Cancer cell line
Web pages Info; ENCODE; -; http://genome.ucsc.edu/ENCODE/protocols/cell/human/MRTTTC549_Crawford_protocol.pdf
Publications

PubMed=8818656; DOI=10.1002/(SICI)1098-2264(199606)16:2<94::AID-GCC3>3.0.CO;2-Y
Jaclyn A. Biegel, Cindy S. Allen, Kazuhiko Kawasaki, Nobuyoshi Shimizu, Marcia L. Budarf, Callum James Bell;
Narrowing the critical region for a rhabdoid tumor locus in 22q11.
Genes Chromosomes Cancer 16:94-105(1996)

PubMed=9559292; DOI=10.1097/00019606-199712000-00004
Atsushi Suzuki, Shigeru Ohta, Morimi Shimada;
Gene expression of malignant rhabdoid tumor cell lines by reverse transcriptase-polymerase chain reaction.
Diagn. Mol. Pathol. 6:326-332(1997)

PubMed=9920784; DOI=10.1006/bbrc.1998.9968
Toshiki Mori, Yoji Fukuda, Hiroshi Kuroda, Takafumi Matsumura, Shigeru Ota, Tohru Sugimoto, Yusuke Nakamura, Johji Inazawa;
Cloning and characterization of a novel Rab-family gene, Rab36, within the region at 22q11.2 that is homozygously deleted in malignant rhabdoid tumors.
Biochem. Biophys. Res. Commun. 254:594-600(1999)

PubMed=10602515; DOI=10.1038/sj.onc.1203168
Marc F. DeCristofaro, Bryan L. Betz, Wei-Dong Wang, Bernard E. Weissman;
Alteration of hSNF5/INI1/BAF47 detected in rhabdoid cell lines and primary rhabdomyosarcomas but not Wilms' tumors.
Oncogene 18:7559-7565(1999)

PubMed=11557780; DOI=10.1038/modpathol.3880401
Eijun Itakura, Sadafumi Tamiya, Keisuke Morita, Hideki Shiratsuchi, Yoshiaki Kinoshita, Yumi Oshiro, Yoshinao Oda, Shigeru Ohta, Masutaka Furue, Masazumi Tsuneyoshi;
Subcellular distribution of cytokeratin and vimentin in malignant rhabdoid tumor: three-dimensional imaging with confocal laser scanning microscopy and double immunofluorescence.
Mod. Pathol. 14:854-861(2001)

PubMed=11921280; DOI=10.1002/gcc.10052
Kaoru Uno, Junko Takita, Kinji Yokomori, Yukichi Tanaka, Shigeru Ohta, Hiroyuki Shimada, Floyd Harry Gilles, Kanji Sugita, Satoshi Abe, Masahiro Sako, Kohei Hashizume, Yasuhide Hayashi;
Aberrations of the hSNF5/INI1 gene are restricted to malignant rhabdoid tumors or atypical teratoid/rhabdoid tumors in pediatric solid tumors.
Genes Chromosomes Cancer 34:33-41(2002)

PubMed=12210830; DOI=10.1002/jnr.10330
Shinobu Yoshida, Tsutomu Narita, Takashi Taga, Shigeru Ohta, Yoshihiro Takeuchi;
Malignant rhabdoid tumor shows incomplete neural characteristics as revealed by expression of SNARE complex.
J. Neurosci. Res. 69:642-652(2002)

PubMed=14662021; DOI=10.1111/j.1349-7006.2003.tb01401.x; PMCID=PMC11160295
Hirofumi Kato, Shigeru Ohta, Shigeki Koshida, Tsutomu Narita, Takashi Taga, Yoshihiro Takeuchi, Kanji Sugita;
Expression of pericyte, mesangium and muscle markers in malignant rhabdoid tumor cell lines: differentiation-induction using 5-azacytidine.
Cancer Sci. 94:1059-1065(2003)

PubMed=16557275; DOI=10.1038/modpathol.3800599
Teiyu Izumi, Yoshinao Oda, Tadashi Hasegawa, Yukihiro Nakanishi, Hiroshi Iwasaki, Hiroshi Sonobe, Hiroaki Goto, Hidenari Kusakabe, Tomonari Takahira, Chikashi Kobayashi, Ken-ichi Kawaguchi ...Show all 16 authors... , Tsuyoshi Saito, Hidetaka Yamamoto, Sadafumi Tamiya, Yukihide Iwamoto, Masazumi Tsuneyoshi; Show fewer authors
Prognostic significance of dysadherin expression in epithelioid sarcoma and its diagnostic utility in distinguishing epithelioid sarcoma from malignant rhabdoid tumor.
Mod. Pathol. 19:820-831(2006)

PubMed=24418192; DOI=10.1111/cas.12352; PMCID=PMC4317948
Junko Takita, Yu-Yan Chen, Motohiro Kato, Kentaro Ohki, Yusuke Sato, Shigeru Ohta, Kanji Sugita, Riki Nishimura, Noriko Hoshino, Masafumi Seki, Masashi Sanada ...Show all 14 authors... , Akira Oka, Yasuhide Hayashi, Seishi Ogawa; Show fewer authors
Genome-wide approach to identify second gene targets for malignant rhabdoid tumors using high-density oligonucleotide microarrays.
Cancer Sci. 105:258-264(2014)

PubMed=31068700; DOI=10.1038/s41586-019-1186-3; PMCID=PMC6697103
Mahmoud Ghandi, Franklin W. Huang, Judit Jane-Valbuena, Gregory V. Kryukov, Christopher C. Lo, E. Robert McDonald 3rd, Jordi Ginesta Barretina, Ellen T. Gelfand, Craig M. Bielski, Hao-Xin Li, Kevin Hu ...Show all 68 authors... , Alexander Y. Andreev-Drakhlin, Jaegil Kim, Julian M. Hess, Brian J. Haas, Francois Aguet, Barbara A. Weir, Michael V. Rothberg, Brenton R. Paolella, Michael Scott Lawrence, Rehan Akbani, Yi-Ling Lu, Hong L. Tiv, Prafulla C. Gokhale, Antoine de Weck, Ali Amin Mansour, Coyin Oh, Juliann Shih, Kevin Hadi, Yanay Rosen, Jonathan Bistline, Kavitha Venkatesan, Anupama Reddy, Dmitriy Sonkin, Manway Liu, Joseph Lehar, Joshua M. Korn, Dale A. Porter, Michael D. Jones, Javad Golji, Giordano Caponigro, Jordan E. Taylor, Caitlin M. Dunning, Amanda L. Creech, Allison C. Warren, James M. McFarland, Mahdi Zamanighomi, Audrey Kauffmann, Nicolas Stransky, Marcin Imielinski, Yosef E. Maruvka, Andrew D. Cherniack, Aviad Tsherniak, Francisca Vazquez, Jacob D. Jaffe, Andrew Alan Lane, David M. Weinstock, Cory M. Johannessen, Michael P. Morrissey, Frank Stegmeier, Robert Schlegel, William Chun Hahn, Gad Getz, Gordon B. Mills, Jesse S. Boehm, Todd Robert Golub, Levi Alexander Garraway, William Raj Sellers; Show fewer authors
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Nature 569:503-508(2019)

Cross-references
Cell line databases/resources Cell_Model_Passport; SIDM01457
DepMap; ACH-001211
Biological sample resources BioSample; SAMN10989627
ENCODE; ENCBS258AAA
Encyclopedic resources Wikidata; Q54973250
Experimental variables resources EFO; EFO_0005700
Gene expression databases GEO; GSM3145597
GEO; GSM3145740
Polymorphism and mutation databases Cosmic; 801776
Cosmic; 802052
Cosmic; 1063888
Cosmic; 2144784
Entry history
Entry creation04-Apr-2012
Last entry update14-Aug-2025
Version number28