Cellosaurus logo
expasy logo

Cellosaurus KOPM-28 (CVCL_7973)

[Text version]
Cell line name KOPM-28
Synonyms KOPM28
Accession CVCL_7973
Resource Identification Initiative To cite this cell line use: KOPM-28 (RRID:CVCL_7973)
Comments Population: Japanese.
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Sequence variations
  • Gene fusion; HGNC; 76; ABL1 + HGNC; 1014; BCR; Name(s)=BCR-ABL1, BCR-ABL; Note=BCR exon 14 fused to ABL1 exon 2 (b3a2 transcript) (PubMed=10071072; PubMed=10576511; PubMed=12506034).
Disease Chronic myelogenous leukemia, BCR-ABL1 positive (NCIt: C3174)
Chronic myeloid leukemia (ORDO: Orphanet_521)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Age at sampling 64Y
Category Cancer cell line
Publications

PubMed=3494166; DOI=10.1016/0145-2126(87)90047-6
Mori T., Nakazawa S., Nishino K., Sugita K., Takane K., Mori M., Sagawa K., Hayashi Y., Sakurai M.
Ph1-positive CML-derived myeloid-monocytoid precursor cell line producing substance(s) that stimulates normal CFU-C.
Leuk. Res. 11:241-249(1987)

PubMed=10071072; DOI=10.1016/S0145-2126(98)00171-4
Drexler H.G., MacLeod R.A.F., Uphoff C.C.
Leukemia cell lines: in vitro models for the study of Philadelphia chromosome-positive leukemia.
Leuk. Res. 23:207-215(1999)

PubMed=10576511; DOI=10.1016/s0145-2126(99)00131-9
Uphoff C.C., Habig S., Fombonne S., Matsuo Y., Drexler H.G.
ABL-BCR expression in BCR-ABL-positive human leukemia cell lines.
Leuk. Res. 23:1055-1060(1999)

DOI=10.1016/B978-0-12-221970-2.50457-5
Drexler H.G.
The leukemia-lymphoma cell line factsbook.
(In) ISBN 9780122219702; pp.1-733; Academic Press; London (2001)

PubMed=12506034; DOI=10.1182/blood-2002-06-1770
Uno K., Inukai T., Kayagaki N., Goi K., Sato H., Nemoto A., Takahashi K., Kagami K., Yamaguchi N., Yagita H., Okumura K., Koyama-Okazaki T., Suzuki T., Sugita K., Nakazawa S.
TNF-related apoptosis-inducing ligand (TRAIL) frequently induces apoptosis in Philadelphia chromosome-positive leukemia cells.
Blood 101:3658-3667(2003)

Cross-references
Encyclopedic resources Wikidata; Q54900295
Polymorphism and mutation databases Cosmic; 787497
Entry history
Entry creation04-Apr-2012
Last entry update02-May-2024
Version number14