Cellosaurus logo
expasy logo

Cellosaurus C666-1 (CVCL_7949)

[Text version]
Cell line name C666-1
Synonyms c666-1; C6661
Accession CVCL_7949
Resource Identification Initiative To cite this cell line use: C666-1 (RRID:CVCL_7949)
Comments Population: Chinese.
Virology: Contains a complete EBV genome (strain C666-1) which has been sequenced (PubMed=23915735; PubMed=25787276).
Doubling time: 3.5 days (PubMed=10449618).
Transformant: NCBI_TaxID; 10376; Epstein-Barr virus (EBV).
Omics: Transcriptome analysis by RNAseq.
Disease Nasopharyngeal carcinoma (NCIt: C3871)
Nasopharyngeal carcinoma (ORDO: Orphanet_150)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_M597 (C666)
Sex of cell Male
Age at sampling Age unspecified
Category Cancer cell line
STR profile Source(s): PubMed=18196576; PubMed=26116706; PubMed=30405107

Markers:
AmelogeninX,Y
CSF1PO11,15 (PubMed=26116706)
11,15,16 (PubMed=18196576; PubMed=30405107)
D2S133816,23
D3S135816,17 (PubMed=18196576; PubMed=30405107)
17 (PubMed=26116706)
D5S81811,12
D7S82010,11,12 (PubMed=26116706)
11,12 (PubMed=18196576; PubMed=30405107)
D8S117911,13,14,15 (PubMed=18196576; PubMed=30405107)
13,15 (PubMed=26116706)
D13S3178,11
D16S53910
D18S5116 (PubMed=18196576; PubMed=30405107)
16,17 (PubMed=26116706)
D19S43313,15.2
D21S1128,29,30.2,31.2 (PubMed=18196576; PubMed=30405107)
29,31.2 (PubMed=26116706)
FGA21,24 (PubMed=26116706)
23,24 (PubMed=18196576; PubMed=30405107)
Penta D9,10
Penta E11,15
TH016,8
TPOX8,11
vWA17,18

Run an STR similarity search on this cell line
Publications

PubMed=10449618; DOI=10.1002/(SICI)1097-0215(19990924)83:1<121::AID-IJC21>3.0.CO;2-F
Cheung S.-T., Huang D.P., Hui A.B.-Y., Lo K.-W., Ko C., Tsang Y.S., Wong N., Whitney B.M., Lee J.C.-K.
Nasopharyngeal carcinoma cell line (C666-1) consistently harbouring Epstein-Barr virus.
Int. J. Cancer 83:121-126(1999)

PubMed=12645650; DOI=10.1016/S0165-4608(02)00657-X
Wong N., Hui A.B.-Y., Fan B.-L., Lo K.-W., Pang E., Leung S.-F., Huang D.P., Johnson P.J.
Molecular cytogenetic characterization of nasopharyngeal carcinoma cell lines and xenografts by comparative genomic hybridization and spectral karyotyping.
Cancer Genet. Cytogenet. 140:124-132(2003)

PubMed=18196576; DOI=10.1002/ijc.23374
Chan S.Y.-Y., Choy K.-W., Tsao S.-W., Tao Q., Tang T., Chung G.T.-Y., Lo K.-W.
Authentication of nasopharyngeal carcinoma tumor lines.
Int. J. Cancer 122:2169-2171(2008)

PubMed=23915735; DOI=10.1186/1750-9378-8-29
Tso K.K.-Y., Yip K.Y.-L., Mak C.K.-Y., Chung G.T.-Y., Lee S.-D., Cheung S.-T., To K.-F., Lo K.-W.
Complete genomic sequence of Epstein-Barr virus in nasopharyngeal carcinoma cell line C666-1.
Infect. Agents Cancer 8:29.1-29.4(2013)

PubMed=24991015; DOI=10.1128/JVI.01457-14
Strong M.J., Baddoo M., Nanbo A., Xu M., Puetter A., Lin Z.
Comprehensive RNA-seq analysis reveals contamination of multiple nasopharyngeal carcinoma cell lines with HeLa cell genomes.
J. Virol. 88:10696-10704(2014)

PubMed=25787276; DOI=10.1128/JVI.03614-14
Palser A.L., Grayson N.E., White R.E., Corton C., Correia S., Ba Abdullah M.M., Watson S.J., Cotten M., Arrand J.R., Murray P.G., Allday M.J., Rickinson A.B., Young L.S., Farrell P.J., Kellam P.
Genome diversity of Epstein-Barr virus from multiple tumor types and normal infection.
J. Virol. 89:5222-5237(2015)

PubMed=26116706; DOI=10.1096/fj.14-266718
Ye F., Chen C.-G., Qin J., Liu J., Zheng C.-Y.
Genetic profiling reveals an alarming rate of cross-contamination among human cell lines used in China.
FASEB J. 29:4268-4272(2015)

PubMed=30405107; DOI=10.1038/s41467-018-06889-5
Lin W.-T., Yip Y.-L., Jia L., Deng W., Zheng H., Dai W., Ko J.M.-Y., Lo K.-W., Chung G.T.-Y., Yip K.Y.-L., Lee S.-D., Kwan J.S.-H., Zhang J., Liu T.-F., Chan J.Y.-W., Kwong D.L.-W., Lee V.H.-F., Nicholls J.M., Busson P., Liu X.-F., Chiang A.K.-S., Hui K.-F., Kwok H., Cheung S.-T., Cheung Y.-C., Chan C.-K., Li B., Cheung A.L.-M., Hau P.-M., Zhou Y., Tsang C.-M., Middeldorp J.M., Chen H.-L., Lung M.L., Tsao S.-W.
Establishment and characterization of new tumor xenografts and cancer cell lines from EBV-positive nasopharyngeal carcinoma.
Nat. Commun. 9:4663.1-4663.17(2018)

Cross-references
Cell line databases/resources Cell_Model_Passport; SIDM01988
Anatomy/cell type resources BTO; BTO:0004805
Chemistry resources ChEMBL-Cells; CHEMBL4482988
ChEMBL-Targets; CHEMBL4483231
PubChem_Cell_line; CVCL_7949
Encyclopedic resources Wikidata; Q54808229
Polymorphism and mutation databases Cosmic; 1017617
Cosmic; 1301000
Entry history
Entry creation04-Apr-2012
Last entry update21-Mar-2023
Version number19