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Cellosaurus 21MT-1 (CVCL_7931)

[Text version]
Cell line name 21MT-1
Synonyms 21-MT-1; 21MT1
Accession CVCL_7931
Resource Identification Initiative To cite this cell line use: 21MT-1 (RRID:CVCL_7931)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: JWGray breast cancer cell line panel.
Characteristics: 21PT is non-tumorigenic whereas 21NT and 21MT-1/21-MT-2 cause tumors in the nude mice system.
Doubling time: 36.8 +- 0.6 hours (Note=In alpha H&E medium), 42.3 +- 4.7 hours (Note=In D medium) (PubMed=8482634); 44.91 hours (JWGray panel).
Omics: Deep exome analysis.
Omics: SNP array analysis.
Omics: Transcriptome analysis by RNAseq.
Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations
  • Mutation; HGNC; 11998; TP53; Simple; p.Ser33Phefs*9 (c.96_97insT); Zygosity=Unspecified (PubMed=7923592).
HLA typing Source: PubMed=25960936
Class I
HLA-AA*31:01,26:01
HLA-BB*38:01,35:02
HLA-CC*04:01,12:03
Class II
HLA-DQDQA1*03:02,03:02
DQB1*03:02,03:02
HLA-DRDRB1*04:02,04:02
Disease Breast carcinoma (NCIt: C4872)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Originate from same individual CVCL_7932 ! 21MT-2
CVCL_7933 ! 21NT
CVCL_7934 ! 21PT
CVCL_IP81 ! H16F1
CVCL_IP82 ! H16N-2
CVCL_IP83 ! H16N-3
Sex of cell Female
Age at sampling 37Y
Category Cancer cell line
Web pages https://www.synapse.org/#!Synapse:syn2346643/wiki/62255
Publications

DOI=10.1007/978-1-4612-0411-4_18
Band V., Sager R.
Tumor progression in breast cancer.
(In book chapter) Neoplastic transformation in human cell system. Mechanism of carcinogenesis; Rhim J.S., Dritschilo A. (eds.); pp.169-178; Humana Press; New York; USA (1990)

PubMed=1977518
Band V., Zajchowski D., Swisshelm K.L., Trask D.K., Kulesa V., Cohen C., Connolly J.L., Sager R.
Tumor progression in four mammary epithelial cell lines derived from the same patient.
Cancer Res. 50:7351-7357(1990)

PubMed=8482634; DOI=10.1016/0360-3016(93)90176-V
Wazer D.E., Joyce M., Jung L., Band V.
Alterations in growth phenotype and radiosensitivity after fractionated irradiation of breast carcinoma cells from a single patient.
Int. J. Radiat. Oncol. Biol. Phys. 26:81-88(1993)

DOI=10.1016/B978-0-12-333530-2.50009-5
Leibovitz A.
Cell lines from human breast.
(In book chapter) Atlas of human tumor cell lines; Hay R.J., Park J.-G., Gazdar A.F. (eds.); pp.161-184; Academic Press; New York; USA (1994)

PubMed=7923592; DOI=10.1093/carcin/15.9.1969
Liu X.-L., Band H., Gao Q.-S., Wazer D.E., Chu Q.-M., Band V.
Tumor cell-specific loss of p53 protein in a unique in vitro model of human breast tumor progression.
Carcinogenesis 15:1969-1973(1994)

PubMed=20458274; DOI=10.1038/labinvest.2010.97
Souter L.H., Andrews J.D., Zhang G.-H., Cook A.C., Postenka C.O., Al-Katib W., Leong H.S., Rodenhiser D.I., Chambers A.F., Tuck A.B.
Human 21T breast epithelial cell lines mimic breast cancer progression in vivo and in vitro and show stage-specific gene expression patterns.
Lab. Invest. 90:1247-1258(2010)

PubMed=24176112; DOI=10.1186/gb-2013-14-10-r110; PMCID=PMC3937590
Daemen A., Griffith O.L., Heiser L.M., Wang N.J., Enache O.M., Sanborn Z., Pepin F., Durinck S., Korkola J.E., Griffith M., Hur J.S., Huh N., Chung J., Cope L., Fackler M.J., Umbricht C.B., Sukumar S., Seth P., Sukhatme V.P., Jakkula L.R., Lu Y.-L., Mills G.B., Cho R.J., Collisson E.A., van 't Veer L.J., Spellman P.T., Gray J.W.
Modeling precision treatment of breast cancer.
Genome Biol. 14:R110.1-R110.14(2013)

PubMed=25960936; DOI=10.4161/21624011.2014.954893; PMCID=PMC4355981
Boegel S., Lower M., Bukur T., Sahin U., Castle J.C.
A catalog of HLA type, HLA expression, and neo-epitope candidates in human cancer cell lines.
OncoImmunology 3:e954893.1-e954893.12(2014)

Cross-references
Cell line databases/resources Cell_Model_Passport; SIDM01902
DepMap; ACH-002400
LINCS_HMS; 51107
LINCS_LDP; LCL-2110
Chemistry resources PharmacoDB; 21MT1_8_2019
Encyclopedic resources Wikidata; Q54583256
Gene expression databases GEO; GSM1172934
GEO; GSM1172846
GEO; GSM3145686
Polymorphism and mutation databases IARC_TP53; 21720
Entry history
Entry creation04-Apr-2012
Last entry update02-May-2024
Version number23